Abstract: The present invention relates to a patterned substrate comprising first regions having first dendrimer structures and second regions having second dendrimer structures on a surface of the substrate, as well as a to method for manufacturing a patterned substrate and the use of a patterned substrate for the chemical synthesis of a chemical synthesis product, as a characterizing platform and/or as a platform for cell treatment and/or cell cultivation.

Abstract: The present invention provides novel amino lipids and a method for synthesizing these compounds.

Abstract: The present invention provides new amino lipids and a convenient method for synthesizing these compounds. These (cationic) amino lipids have good properties as transfection agents. The method is an economic versatile two step synthesis allowing the preparation of various amino lipids thus leading to the assembly of a combinatorial library of transfection agents. Moreover, the present invention provides lipid particles (liposomes) containing said amino lipids and their use for delivering bioactive agents into cells. The invention encompasses also the use of lipid particles containing the cationic amino lipids as medicament.

Abstract: The present invention provides new amino lipids and a convenient method for synthesising these compounds. These (cationic) amino lipids have good properties as transfection agents. The method is an economic versatile two step synthesis allowing the preparation of various amino lipids thus leading to the assembly of a combinatorial library of transfection agents. Moreover, the present invention provides lipid particles (liposomes) containing said amino lipids and their use for delivering bioactive agents into cells. The invention encompasses also the use of lipid particles containing the cationic amino lipids as medicament.

Abstract: The present invention relates to a substrate with a solid support coated with a porous hydrophobic polymer layer or film, wherein said polymer layer or film is coated with a water-immiscible hydrophobic liquid forming a stable film on the polymer surface. The present invention further relates to a method of forming a protein- and cell-repellent surface, comprising the steps of providing a substrate with a solid support coated with a porous hydrophobic polymer layer or film, and applying a water-immiscible hydrophobic liquid to said porous hydrophobic polymer layer or film, a respective method of preventing the formation of biofilms, adhesion of cells and bacteria, and/or migration of cells and bacteria on a surface, as well as the use of a porous hydrophobic polymer layer or film that is coated with a water-immiscible hydrophobic liquid for forming a protein-, cell- and bacteria-repellent surface.

Abstract: The present invention relates to a method of forming an array of separated homogenous fluid microdroplets or hydrogel micropads of a desired shape and size in a desired spatial pattern, comprising the steps of providing a patterned substrate with a solid support coated with a porous polymer layer or film comprising hydrophilic areas having the desired shape and size, surrounded by hydrophobic areas separating the hydrophilic areas into the desired spatial pattern, and applying the fluid to a multitude of the hydrophilic areas at the same time.

Abstract: The present invention relates to a method for making arrays or patterns comprising hydrophilic areas and hydrophobic background surrounding the hydrophilic areas, methods of cultivating cells using these arrays or patterns, and uses of these arrays or patterns in cell cultivation methods, e.g. for cell patterning, cell screenings, cell transfection and cell co-culturing.

Abstract: A broadly applicable method requiring no more than a single step facilitates the preparation of large area super hydrophobic or super hydrophilic surfaces on a variety of substrates such as such as glass, metal, plastic, paper, wood, concrete and masonry. The technique involves the free radical polymerization of common acrylic or styrenic monomers in the presence of porogenic solvents in a mold or on a free surface. The material can be semi- or fully-transparent and either super hydrophobic or super hydrophilic depending on the choice of the monomers. Because porosity and dual scale roughness are intrinsic bulk properties of the monolithic materials and not only a surface characteristic, the polymers can be powdered to produce a super hydrophobic powder or otherwise fragmented and attached to the surface of any object to render it super hydrophobic or super hydrophilic. The surface properties of the porous material may also be altered locally by photografting with selected monomers.