Patents by Inventor Pavel A. NIKITIN

Pavel A. NIKITIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-38-SPECIFIC ANTIBODIES
    Publication number: 20240174741
    Abstract: This invention relates to antibodies specific for human interleukin-38 (IL-38), including isolated antibodies, or antigen-binding fragments thereof. The antibodies, or antigen-binding fragments thereof, described herm partially or fully block, inhibit, or neutralize a biological activity of IL 38. Methods described herm relate to inhibiting tumor growth or metastasis in an individual afflicted by tumor growth and/or metastasis.
    Type: Application
    Filed: March 28, 2022
    Publication date: May 30, 2024
    Inventors: Matthew K. ROBINSON, Karen LUNDGREN, Ben HARMAN, Pavel A. NIKITIN, Fang SHEN
  • IL-38-SPECIFIC ANTIBODIES
    Publication number: 20220275077
    Abstract: This invention relates to antibodies specific for human interleukin-38 (IL-38), including isolated antibodies, or antigen-binding fragments thereof. The antibodies, or antigen-binding fragments thereof, described here partially or fully block, inhibit, or neutralize a biological activity of IL 38. Methods described here relate to inhibiting tumor growth or metastasis in an individual afflicted by tumor growth and/or metastasis.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 1, 2022
    Inventors: Matthew K. ROBINSON, Karen LUNDGREN, Ben HARMAN, Pavel A. NIKITIN, John P. DOWLING
  • METHODS OF TREATING AUTOIMMUNE AND ALLOIMMUNE DISORDERS
    Publication number: 20220249664
    Abstract: The present disclosure provides methods of treating an alloimmune or autoimmune disorder in an individual; the methods involve administering to the individual an effective amount of an antibody specific for complement component C1s. The present disclosure provides a method of monitoring, the efficacy of a subject treatment method; the method involves detecting the level of autoantibody or alloantibody in a biological sample obtained from the individual.
    Type: Application
    Filed: September 8, 2021
    Publication date: August 11, 2022
    Applicant: Bioverativ USA Inc.
    Inventors: Graham Parry, Pavel A. Nikitin, Sandip Panicker
  • Methods of inducing complement activity
    Patent number: 11192944
    Abstract: The present disclosure provides methods of inducing a complement activity on a surface of a cell comprising contacting the cell with an effective amount of an anti-Factor B antibody, wherein the anti-Factor B antibody inhibits dissociation of a C3bBb complex into a Factor Bb and a C3b.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: December 7, 2021
    Assignee: Bioverativ USA Inc.
    Inventors: Sandip Panicker, Stephen Moore, Pavel A. Nikitin, Tony Byun, Graham Parry
  • METHODS OF INDUCING COMPLEMENT ACTIVITY
    Publication number: 20200239556
    Abstract: The present disclosure provides methods of inducing a complement activity on a surface of a cell comprising contacting the cell with an effective amount of an anti-Factor B antibody, wherein the anti-Factor B antibody inhibits dissociation of a C3bBb complex into a Factor Bb and a C3b.
    Type: Application
    Filed: October 11, 2018
    Publication date: July 30, 2020
    Applicant: Bioverativ USA Inc.
    Inventors: Sandip Panicker, Stephen Moore, Pavel A. Nikitin, Tony Byun, Graham Parry
  • METHODS OF TREATING AUTOIMMUNE AND ALLOIMMUNE DISORDERS
    Publication number: 20180169240
    Abstract: The present disclosure provides methods of treating an alloimmune or autoimmune disorder in an individual; the methods involve administering to the individual an effective amount of an antibody specific for complement component C1s. The present disclosure provides a method of monitoring the efficacy of a subject treatment method; the method involves detecting the level of autoantibody or alloantibody in a biological sample obtained from the individual.
    Type: Application
    Filed: June 23, 2016
    Publication date: June 21, 2018
    Applicant: Bioverativ USA Inc.
    Inventors: Graham PARRY, Pavel A. NIKITIN, Sandip PANICKER