Patents by Inventor Pavel Bobal

Pavel Bobal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing pyrrole derivatives and intermediates
    Patent number: 7932403
    Abstract: The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: April 26, 2011
    Assignee: ratiopharm GmbH
    Inventors: Pavel Bobal, Jaroslav Frantisek, Jiri Stohandl, Kane Denike, Armin Boerner, Vitali Tararov, Andrei Korostylev, Gerd Koenig, Nicolas Jeker
  • PROCESS FOR THE PREPARATION OF VALSARTAN AND INTERMEDIATE PRODUCTS
    Publication number: 20100217008
    Abstract: The present invention relates to a new method for the production of valsartan, a valine derivative having the chemical N name is (S)—N-(1-carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2?-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amine, and pharmacologically acceptable salts thereof. Furthermore the invention relates to new intermediate compounds which are suitable for the production of valsartan and new methods for the production of intermediate compounds which are suitable for the production of valsartan.
    Type: Application
    Filed: December 11, 2007
    Publication date: August 26, 2010
    Applicant: ratiopharm GmbH
    Inventors: Jiri Stohandl, Pavel Bobal, Jaroslav Frantisek
  • Process for Preparing Pyrrole Derivatives and Intermediates
    Publication number: 20090012312
    Abstract: The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).
    Type: Application
    Filed: December 16, 2005
    Publication date: January 8, 2009
    Inventors: Pavel Bobal, Jaroslav Frantisek, Jiri Stohandl, Kane Denike, Armin Boerner, Vitali Tararov, Andrci Korostylev, Gerd Koenig, Nicolas Jeker