Abstract: An antibiotic compound of formula (I): or a salt or stereoisomer thereof; wherein: R1-R3 and R5-R6 are independently selected from H or a C1-C5 alkyl group or a C1-C5 substituted alkyl group; R4 is a C1-C5 alkyl group or a C1-C5 substituted alkyl group; X1-X2 are independently selected from the group consisting of ?O, H, and OH; Y is an acyclic hydrocarbon chain having 2 to 20 carbon atoms or a substituted acyclic hydrocarbon chain having 2 to 20 carbon atoms; and Z is a neutral or positively charged organic group including a nitrogen or phosphorus atom, the nitrogen or phosphorous atom forming a covalent bond with a carbon atom of Y. Also disclosed are methods of treating a bacterial disease including administering an effective amount of the compound to a subject in need thereof, wherein the bacterial disease is caused by a gram-negative bacteria.

Abstract: Described herein is a process for antibiotic development comprising: (a) generating a compound of formula (III): or a salt or stereoisomer or prodrug thereof; wherein R1-R3 and R5-R10 are independently selected from H, alkyl group, substituted alkyl group, halogen, OH, NH2, or SH; R4 is H, alkyl group or substituted alkyl group; X1-X2 are independently selected from ?O, ?S, ?NH, H, alkyl, halogen, OH, SH, or NH2; W is a saturated acyclic hydrocarbon chain of 1 to 15 carbon atoms; and Z is a neutral or positively charged organic group comprising a nitrogen or phosphorus atom; and; and (b) determining efficacy of the compound to inhibit growth of a bacteria. Systems of drug development of these antibiotic compounds are also described.

Abstract: Described herein is a process for antibiotic development comprising: (a) generating a compound of formula (III): or a salt or stereoisomer or prodrug thereof; wherein R1-R3 and R5-R10 are independently selected from H, alkyl group, substituted alkyl group, halogen, OH, NH2, or SH; R4 is H, alkyl group or substituted alkyl group; X1-X2 are independently selected from ?O, ?S, ?NH, H, alkyl, halogen, OH, SH, or NH2; W is a saturated acyclic hydrocarbon chain of 1 to 15 carbon atoms; and Z is a neutral or positively charged organic group comprising a nitrogen or phosphorus atom; and; and (b) determining efficacy of the compound to inhibit growth of a bacteria. Systems of drug development of these antibiotic compounds are also described.

Abstract: An antibiotic compound of formula (III): or a salt or stereoisomer thereof; wherein R1-R3 and R5-R10 are independently selected from the group consisting of H, alkyl group, substituted alkyl group, halogen, OH, NH2 and SH; R4 is H, alkyl group or substituted alkyl group; X1-X2 are independently selected from the group consisting of ?O, ?S, NH, H, alkyl, halogen, OH, SH and NH2; W is a saturated acyclic hydrocarbon chain of 1 to 15 carbon atoms; and Z is a neutral or positively charged organic group. The compounds are useful in treating bacterial diseases.

Abstract: An antibiotic compound of formula (III): or a salt or stereoisomer thereof; wherein R1-R3 and R5-R10 are independently selected from the group consisting of H, alkyl group, substituted alkyl group, halogen, OH, NH2 and SH; R4 is H, alkyl group or substituted alkyl group; X1-X2 are independently selected from the group consisting of ?O, ?S, NH, H, alkyl, halogen, OH, SH and NH2; W is a saturated acyclic hydrocarbon chain of 1 to 15 carbon atoms; and Z is a neutral or positively charged organic group. The compounds are useful in treating bacterial diseases.

Abstract: An antibiotic compound is of formula (I): R1-R3, R5 and R6 are independently selected from H, alkyl group, substituted alkyl group, halogen, OH, NH2, or SH; R4 is H, alkyl group or substituted alkyl group. X1-X2 are independently selected from O, S, NH, H, alkyl, halogen, OH, SH, or NH2. Y is an acyclic hydrocarbon chain having 4 to 20 carbon atoms or a substituted acyclic hydrocarbon chain having 4 to 20 carbon atoms, but does not include an oxygen atom. Z is CH3 or any neutral or positively charged group. The compound can also be a salt or stereoisomer of formula (I). The compounds are useful in treating bacterial diseases.

Abstract: An antibiotic compound is of formula (I): R1-R3, R5 and R6 are independently selected from H, alkyl group, substituted alkyl group, halogen, OH, NH2, or SH; R4 is H, alkyl group or substituted alkyl group. X1-X2 are independently selected from O, S, NH, H, alkyl, halogen, OH, SH, or NH2 Y is an acyclic hydrocarbon chain having 4 to 20 carbon atoms or a substituted acyclic hydrocarbon chain having 4 to 20 carbon atoms, but does not include an oxygen atom. Z is CH3 or any neutral or positively charged group. The compound can also be a salt or stereoisomer of formula (I). The compounds are useful in treating bacterial diseases.