Patents by Inventor Pavel Hozak

Pavel Hozak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nuclear myosin I &bgr;with a 16 amino acid N-terminal extension
    Patent number: 6831156
    Abstract: The present invention relates to a molecular motor actin binding protein, in particular, to Nuclear Myosin I&bgr; (NMI&bgr;) containing a 16 amino acid N-terminal extension involved in transcription. More particularly, this invention is directed to a molecule with oligonucleotide sequence coding for a protein nuclear Myosin I&bgr; (NMI&bgr;) containing a 16 amino acid N-terminal extension that co-localizes with, and forms functional complexes with, RNA polymerase II. This invention is also directed to polyclonal and monoclonal antibodies to the 16 amino acid N-terminal extension that block in vitro RNA synthesis. This invention is also directed to administration to a cell of polyclonal or monoclonal antibodies to the NMI&bgr; 16 amino acid N-terminal extension sequence or to an epitope within that sequence to inhibit transcription. Other inhibitors are also suitable. This invention may be used to treat illness through targeted inhibition of cell proliferation.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: December 14, 2004
    Inventors: Primal de Lanerolle, Grzegorz Nowak, Lidija Pestic-Dragovich, Ljuba Stojilkovic, Pavel Hozak
  • Nuclear myosin I beta with a 16 amino acid N-terminal extension
    Publication number: 20030186375
    Abstract: The present invention relates to a molecular motor actin binding protein, in particular, to Nuclear Myosin I &bgr; (NMI &bgr;) containing a 16 amino acid N-terminal extension involved in transcription. More particularly, this invention is directed to a molecule with oligonucleotide sequence coding for a protein nuclear Myosin I &bgr; (NMI &bgr;) containing a 16 amino acid N-terminal extension that co-localizes with, and forms functional complexes with, RNA polymerase II. This invention is also directed to polyclonal and monoclonal antibodies to the 16 amino acid N-terminal extension that block in vitro RNA synthesis. This invention is also directed to administration to a cell of polyclonal or monoclonal antibodies to the NMI &bgr; 16 amino acid N-terminal extension sequence or to an epitope within that sequence to inhibit transcription. Other inhibitors are also suitable. This invention may be used to treat illness through targeted inhibition of cell proliferation.
    Type: Application
    Filed: November 4, 2002
    Publication date: October 2, 2003
    Applicant: Primal de Lanerolle
    Inventors: Primal de Lanerolle, Grzegorz Nowak, Lidija Pestic-Dragovich, Ljuba Stojilkovic, Pavel Hozak
  • Nuclear myosin l beta with a 16 amino acid N-terminal extension
    Publication number: 20030017511
    Abstract: The present invention relates to a molecular motor actin binding protein, in particular, to Nuclear Myosin I&bgr; (NMI&bgr;) containing a 16 amino acid N-terminal extension involved in transcription. More particularly, this invention is directed to a molecule with oligonucleotide sequence coding for a protein nuclear Myosin I&bgr; (NMI&bgr;) containing a 16 amino acid N-terminal extension that co-localizes with, and forms functional complexes with, RNA polymerase II. This invention is also directed to polyclonal and monoclonal antibodies to the 16 amino acid N-terminal extension that block in vitro RNA synthesis. This invention is also directed to administration to a cell of polyclonal or monoclonal antibodies to the NMI&bgr; 16 amino acid N-terminal extension sequence or to an epitope within that sequence to inhibit transcription. Other inhibitors are also suitable. This invention may be used to treat illness through targeted inhibition of cell proliferation.
    Type: Application
    Filed: June 27, 2001
    Publication date: January 23, 2003
    Inventors: Primal de Lanerolle, Grzegorz Nowak, Lidija Pestic-Dragovich, Ljuba Stojilkovic, Pavel Hozak