Patents by Inventor Pavel Hrbas

Pavel Hrbas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogs of vasopressin
    Patent number: 4482486
    Abstract: Vasopressin analogs of the formula ##STR1## wherein R.sup.1 is H, R.sup.2 is CH.sub.2 S and R.sup.3 is D-Arg,R.sup.1 is NH.sub.2, R.sup.2 is S-S and R.sup.3 is D-Arg or L-Orn are described. The described analogs resist enzymatic cleavage while retaining their effect on the central nervous system. These compounds lack a glycinamide residue in the 9 position and have the L-arginine in the 8 position replaced with its stereoisomeric form or with an ornithine residue. The compounds evidence little or no peripheral endocrine effects of natural vasopressin.
    Type: Grant
    Filed: April 20, 1983
    Date of Patent: November 13, 1984
    Assignee: Ceskoslovenska akademie ved
    Inventors: Frantisek Brtnik, Tomislav Barth, Pavel Hrbas, Karel Jost, Ivan Krejci, Bela Kupkova, Alena Machova, Linda Servitova, Jana Skopkova