Patents by Inventor Pavel Kamaev

Pavel Kamaev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9020580
    Abstract: Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: April 28, 2015
    Assignee: Avedro, Inc.
    Inventors: Marc D. Friedman, Pavel Kamaev, David Muller, Radha Pertaub, Ronald Scharf, Evan Sherr, David Usher
  • Publication number: 20140343480
    Abstract: Various agents and additives for cross-linking treatments are identified in disclosed studies. The characteristics of the various agents and additives may be advantageously employed in formulations applied in cross-linking treatments of the eye. In some embodiments, riboflavin is combined with Iron(II) to enhance the cross-linking activity generated by the riboflavin. In other embodiments, cross-linking treatments employ an Iron(II) solution in combination with a hydrogen peroxide pre-soak. In yet other embodiments, 2,3-butanedione is employed to increase the efficacy of corneal cross-linking with a photosensitizer, such as riboflavin. In further embodiments, folic acid is employed in combination with a photosensitizer, such as riboflavin, to enhance cross-linking activity. In yet further embodiments, 2,3-butanedione, folic acid, a quinoxaline, a quinoline, dibucaine, Methotrexate, menadione, or a derivative thereof is applied as a cross-linking agent.
    Type: Application
    Filed: May 19, 2014
    Publication date: November 20, 2014
    Applicant: AVEDRO, INC.
    Inventors: Pavel Kamaev, Marc D. Friedman, Evan Sherr, David Muller
  • Publication number: 20130245536
    Abstract: A method for controlling activation of a cross-linking agent applied to an eye includes applying the cross-linking agent to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the cross-linking agent with pulsed light illumination. The pulsed light illumination has a selectable wavelength, irradiance, dose, and on/off duty cycle. The wavelength, the irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for cross-linking activity and to control photochemical efficiency, depth of cross-linking, and density of cross-linking.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 19, 2013
    Applicant: Avedro, Inc.
    Inventors: Marc D. Friedman, Evan Sherr, Pavel Kamaev, William Eddington, David Muller, David Usher, Radha Pertaub, Satish Herekar
  • Publication number: 20120310083
    Abstract: Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
    Type: Application
    Filed: June 4, 2012
    Publication date: December 6, 2012
    Applicant: Avedro, Inc.
    Inventors: Marc D. Friedman, Pavel Kamaev, David Muller, Radha Pertaub, Ronald Scharf, Evan Sherr, David Usher
  • Publication number: 20120289886
    Abstract: Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.
    Type: Application
    Filed: May 18, 2012
    Publication date: November 15, 2012
    Applicant: Avedro, Inc.
    Inventors: David Muller, John Marshall, Stephen L. Trokel, Peter Hersh, Pavel Kamaev
  • Publication number: 20120215155
    Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
    Type: Application
    Filed: April 3, 2012
    Publication date: August 23, 2012
    Applicant: Avedro Inc.
    Inventors: David Muller, John Marshall, Marc D. Friedman, Stephen Blinn, Ronald Scharf, Pavel Kamaev, Radha Pertaub
  • Publication number: 20110288466
    Abstract: Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.
    Type: Application
    Filed: April 13, 2011
    Publication date: November 24, 2011
    Applicant: AVEDRO, INC.
    Inventors: David Muller, John Marshall, Stephen L. Trokel, Peter Hersh, Pavel Kamaev
  • Publication number: 20110237999
    Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
    Type: Application
    Filed: March 18, 2011
    Publication date: September 29, 2011
    Applicant: Avedro Inc.
    Inventors: David Muller, John Marshall, Marc D. Friedman, Stephen Blinn, Ronald Scharf, Pavel Kamaev, Radha Pertaub
  • Publication number: 20100298744
    Abstract: Disclosed herein are method(s) and device(s) capable of generating a small lesion as deep as a few millimeters beneath the skin's surface and several cubic millimeters in volume in orders of magnitude less time, namely, tens of milliseconds. More specifically, in one exemplary embodiment, a method of treating tissue (e.g., skin) is provided which includes generating one or more ultrasound pulses with each pulse having a pulse width shorter than a thermal relaxation time of a tissue treatment volume, and applying one or more of said ultrasound pulses to at least one portion of the tissue treatment volume to generate one or more treatment areas in a region. Methods of treating tissue can include effecting a therapeutic treatment in said region of the tissue, and/or effecting a cosmetic treatment in said target region.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 25, 2010
    Applicant: PALOMAR MEDICAL TECHNOLOGIES, INC.
    Inventors: Gregory B. Altshuler, Christopher Gaal, Pavel Kamaev, Oldrich M. Laznicka, JR., Ilya Yaroslavsky
  • Publication number: 20080154157
    Abstract: Methods and devices are disclosed for treatment of tissue, such as skin tissue, using acoustic energy, such as ultrasound. The ultrasound can be used for various purposes include hair removal and permanent hair reduction, removal of tattoos, and other cosmetic procedures. In some embodiments, ultrasound is produced using an optical-to-acoustic converter, and, in some embodiments, ultrasound is focused.
    Type: Application
    Filed: December 13, 2007
    Publication date: June 26, 2008
    Applicant: PALOMAR MEDICAL TECHNOLOGIES, INC.
    Inventors: Gregory B. Altshuler, Mikhail Smirnov, IIya Yaroslavsky, Pavel Kamaev, Andrei V. Erofeev