Abstract: The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication.

Abstract: Disclosed herein is a ketogenic food composition and methods thereof. The ketogenic food composition promotes ketogenesis in a subject in need thereof. The ketogenic food composition includes fat, protein, and carbohydrate. A ratio of fat to a combination of protein and carbohydrate in the ketogenic food composition may be about 2.5:1 to about 4.5:1. The ketogenic food composition may be a sole diet for the subject. Also provided herein is a method of treating a disease in a subject in need thereof. The method includes administering the ketogenic food composition to the subject. The disease may be a cancer or an obesity-related disorder.

Abstract: The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication.

Abstract: The invention relates to the biodegradable fibres which are based on hydrophobic derivatives of hylauronan, specifically on the base of the hyaluronan derivative C11-C18-acylated on hydroxyl groups of hyaluronic acid, and use thereof. Further the invention relates to the preparation of these fibres which is performed with the use of the wet spinning method in a coagulation bath comprising water solution of organic acid, with the production of continuous monofiles which can be thereafter processed to threads and further to textiles, knitted textiles, or nonwoven textiles. These textiles, knitted textiles or nonwoven textiles can be used for example for the production of implantable surgical material for human and veterinary medicine.

Abstract: The present invention relates to the preparation of textile processable endless monofilaments and multifilaments on the basis of hyaluronan which has been selectively oxidized to aldehyde in the position 6 of its/V-acetyl-D-glucosamine group and to the subsequent modification of such filaments with low molecular dihydrazides. The fibres as well as the fabrics, which are subsequently prepared from the former, exhibit a time-varying solubility in saline depending on the external modification of the fibres. After having been externally modified, the fibres as well as the fabrics exhibit a prolong period of transition into an evenly distributed gel layer. The externally modified fibrous materials retain their full biocompatibility.

Abstract: The subject-matter of the invention is a photoreactive derivative of hyaluronic acid (formula I) and the method of preparation thereof, where first an aldehyde derivative of hyaluronic acid is prepared, oxidized in the position 6 of the glucosamine cycle and then the oxidized derivative reacts with an amine carrying a photoreactive species, for example 1-(2-aminoethyl)pyridine-2(1H)-one, in the presence of a reducing agent, forming a photoreactive derivative. The prepared photoreactive derivative may be then photocrosslinked, wherein the reaction is based on [4+4] photocycloaddition.

Abstract: A pharmaceutical composition comprising at least 0.1 ?mol of formaurindicarboxylic acid or its derivatives in 1 kg of pharmaceutically acceptable carrier. The pharmaceutical composition of claim 1 wherein the composition is in the form of solution prepared using aqueous alcali or water.

Abstract: A pharmaceutical composition comprising at least 0.1 ?mol of formaurindicarboxylic acid or its derivatives in 1 kg of pharmaceutically acceptable carrier. The pharmaceutical composition of claim 1 wherein the composition is in the form of solution prepared using aqueous alcali or water.

Abstract: A pharmaceutical composition comprising at least 0.1 ?mol of formaurindicarboxylic acid or its derivatives in 1 kg of pharmaceutically acceptable carrier. The pharmaceutical composition of claim 1 wherein the composition is in the form of solution prepared using aqueous alcali or water.

Abstract: A pharmaceutical composition comprising at least 0.1 ?mol of formaurindicarboxylic acid or its derivatives in 1 kg of pharmaceutically acceptable carrier. The pharmaceutical composition of claim 1 wherein the composition is in the form of solution prepared using aqueous alcali or water.