Patents by Inventor Pavel Krasutsky

Pavel Krasutsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triterpene quaternary salts as biologically active surfactants
    Publication number: 20050059642
    Abstract: The invention provides novel compounds that are quaternary amine derivatives of betulin and other triterpenes. The compounds have antibacterial, antifungal, and surfactant properties.
    Type: Application
    Filed: July 16, 2004
    Publication date: March 17, 2005
    Inventors: Pavel Krasutsky, Dmytro Avilov, Tatiana Sergeeva, Dmytro Krasutskyy, Oksana Kolomitsyna
  • Methods for manufacturing betulinic acid
    Patent number: 6867314
    Abstract: The present invention provides a method for preparing an ester of betulin at the 3-position, e.g., betulin-3-acetate, including the selective alcoholysis of a betulin-3,28-diester, e.g., betulin-3,28-diacetate; a method for preparing betulin-3-acetate including (1) acetylating betulin to provide betulin-3,28-diacetate and (2) the alcoholysis of betulin-3,28-diacetate to provide betulin-3-acetate; and a method for preparing betulinic acid (1) acetylating betulin to provide betulin-3,28-diacetate, (2) the alcoholysis of betulin-3,28-diacetate to provide betulin-3-acetate, (3) oxidizing betulin-3-acetate to provide betulinic aldehyde-3-acetate, (4) oxidizing betulinic aldehyde-3-acetate to provide betulinic acid-3-acetate, and (5) deprotecting betulinic acid-3-acetate to provide betulinic acid.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: March 15, 2005
    Assignee: Regents of the University of Minnesota
    Inventor: Pavel A. Krasutsky
  • Birch bark processing and the isolation of natural products from birch bark
    Patent number: 6815553
    Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: November 9, 2004
    Assignee: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko, Igor V. Kolomitsyn, Chris F. Edwardson
  • Isolation of natural products from birch bark
    Patent number: 6768016
    Abstract: The invention provides methods for isolating 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers, fatty acids; and mixtures thereof from birch bark.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: July 27, 2004
    Assignee: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Igor V. Kolomitsyn
  • Triterpenes having antibacterial activity
    Publication number: 20040097436
    Abstract: Methods of treating a bacterial infection and of killing or inhibiting bacteria are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.
    Type: Application
    Filed: November 11, 2003
    Publication date: May 20, 2004
    Applicant: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Raj Karim
  • Triterpenes having antibacterial activity
    Patent number: 6689767
    Abstract: Methods of treating a bacterial infection and of killing or inhibiting bacteria are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: February 10, 2004
    Assignee: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Raj Karim
  • Process for extracting compounds from plants
    Publication number: 20040009242
    Abstract: The present invention provides a method for selectively extracting acidic and/or non-acidic compounds from natural material such as plant tissue.
    Type: Application
    Filed: May 9, 2003
    Publication date: January 15, 2004
    Applicant: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Vitaliy V. Nesterenko
  • Triterpenes having human antifungal and antiyeast activity
    Patent number: 6642217
    Abstract: Methods of treating a fungal or yeast infection and of killing or inhibiting fungi or yeast are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: November 4, 2003
    Assignee: Naturtek, LLC
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Raj Karim
  • Birch bark processing and the isolation of natural products from birch bark
    Patent number: 6634575
    Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: October 21, 2003
    Assignee: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko, Igor M. Kolomitsyn, Chris F. Edwardson
  • Isolation of natural products from birch bark
    Publication number: 20030109727
    Abstract: The invention provides methods for isolating 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers, fatty acids; and mixtures thereof from birch bark.
    Type: Application
    Filed: June 26, 2002
    Publication date: June 12, 2003
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Igor V. Kolomitsyn
  • Methods for manufacturing betulinic acid
    Publication number: 20030073858
    Abstract: The present invention provides a method for preparing betulin-3-acetate including alcoholyzing betulin 3,28-dibenzoate; a process for preparing betulin-3-acetate including: (1) acylating betulin to provide betulin 3,28-dibenzoate and (2) alcoholyzing betulin 3,28-dibenzoate to provide betulin-3-acetate; and a process for preparing betulinic acid including: (1) acylating betulin to provide betulin 3,28-dibenzoate; (2) alcoholyzing betulin 3,28-dibenzoate to provide betulin-3-acetate; (3) oxidizing betulin-3-acetate to provide betulinic aldehyde-3-acetate; (4) oxidizing betulinic aldehyde-3-acetate to provide betulinic acid-3-acetate; and (5) deprotecting betulinic acid-3-acetate to provide betulinic acid.
    Type: Application
    Filed: July 11, 2002
    Publication date: April 17, 2003
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko
  • Compositions including fluorinated peroxides, methods of making, and the use thereof
    Publication number: 20030004369
    Abstract: Methods of making compositions including fluorinated peroxides are disclosed. The compositions are useful, for example, for reacting with organic compounds. In one embodiment, novel peroxides are provided.
    Type: Application
    Filed: June 5, 2002
    Publication date: January 2, 2003
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Igor V. Kolomitsyn, Hong Wang
  • Process for extracting compounds from plants
    Publication number: 20020155177
    Abstract: The present invention provides a method for selectively extracting acidic and/or non-acidic compounds from natural material such as plant tissue.
    Type: Application
    Filed: January 17, 2002
    Publication date: October 24, 2002
    Inventors: Pavel A. Krasutsky, Vitaliy V. Nesterenko
  • Triterpenes having human antifungal and antiyeast activity
    Publication number: 20020128210
    Abstract: Methods of treating a fungal or yeast infection and of killing or inhibiting fungi or yeast are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.
    Type: Application
    Filed: October 1, 2001
    Publication date: September 12, 2002
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Raj Karim
  • Triterpenes having antibacterial activity
    Publication number: 20020119935
    Abstract: Methods of treating a bacterial infection and of killing or inhibiting bacteria are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.
    Type: Application
    Filed: October 1, 2001
    Publication date: August 29, 2002
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Raj Karim
  • Process for extracting compounds from plants
    Publication number: 20020114853
    Abstract: The present invention provides a method for selectively extracting acidic and/or non-acidic compounds from natural material such as plant tissue.
    Type: Application
    Filed: October 1, 2001
    Publication date: August 22, 2002
    Inventors: Pavel A. Krasutsky, Vitaliy V. Nesterenko
  • Methods for manufacturing betulinic acid
    Patent number: 6407270
    Abstract: The present invention provides a method for preparing an ester of betulin at the 3-position, e.g., betulin-3-acetate, including the selective alcoholysis of a betulin-3,28-diester, e.g., betulin-3,28-diacetate; a method for preparing betulin-3-acetate including (1) acetylating betulin to provide betulin-3,28-diacetate and (2) the alcoholysis of betulin-3,28-diacetate to provide betulin-3-acetate; a method for preparing betulinic acid from betulin-3-acetate including (1) acetylating betulin to provide betulin-3,28-diacetate, (2) the alcoholysis of betulin-3,28-diacetate to provide betulin-3-acetate, (3) oxidizing betulin-3-acetate to provide betulinic aldehyde-3-acetate, (4) oxidizing betulinic aldehyde-3-acetate to provide betulinic acid-3-acetate, and (5) deprotecting betulinic acid-3-acetate to provide betulinic acid.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: June 18, 2002
    Assignee: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko
  • Birch bark processing and the isolation of natural products from birch bark
    Publication number: 20020070167
    Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.
    Type: Application
    Filed: February 6, 2002
    Publication date: June 13, 2002
    Applicant: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko, Igor V. Kolomitsyn, Chris F. Edwardson
  • Birch bark processing and the isolation of natural products from birch bark
    Patent number: 6392070
    Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: May 21, 2002
    Assignee: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko
  • Birch bark processing and the isolation of natural products from birch bark
    Publication number: 20020043577
    Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.
    Type: Application
    Filed: August 23, 2001
    Publication date: April 18, 2002
    Applicant: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko, Igor M. Kolomitsyn, Chris F. Edwardson