Patents by Inventor Pavel Nagorny

Pavel Nagorny has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIRAL PHOSPHORIC ACIDS IMMOBILIZED ON SOLID SUPPORT FOR THE SELECTIVE PROTECTION OF HYDROXYL GROUPS
    Publication number: 20240066509
    Abstract: Provided herein are immobilized chiral phosphoric acids and methods of using immobilized chiral phosphoric acids as catalysts for protecting group reactions.
    Type: Application
    Filed: August 9, 2023
    Publication date: February 29, 2024
    Inventors: Pavel Nagorny, Iaroslav Khomutnyk, Sibin Wang, Oleksii Zhelavskyi
  • Spiroketal-based C2-symmetric scaffold for asymmetric catalysis
    Patent number: 10565015
    Abstract: Provided herein is a compound of formula (I): wherein each R is independently selected from the group consisting of C1-8 alkyl, C1-8 heteroalkyl having 1-4 heteroatoms independently selected from N, O, and S, C3-6 cycloalkyl, 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N, O, and S, C6-10 aryl, and 5-10 membered heteroaryl having 1-4 heteroatoms independently selected from N, O, and S; each X is independently selected from OH, PAr2, P(O)Ar2, OPAr2, C3-6 cycloalkyl, 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N, O, and S or each X together form O2PNR?2; Ar is C6-10aryl; and each R? is independently selected from hydrogen and C1-8 alkyl. Also provided are methods of making and using the compound of formula (I).
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: February 18, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Pavel Nagorny, Siyuan Sun, Alonso Arguelles
  • Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis
    Publication number: 20190084995
    Abstract: Provided herein is a compound of formula (I): wherein each R is independently selected from the group consisting of C1-8 alkyl, C1-8 heteroalkyl having 1-4 heteroatoms independently selected from N, O, and S, C3-6 cycloalkyl, 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N, O, and S, C6-10 aryl, and 5-10 membered heteroaryl having 1-4 heteroatoms independently selected from N, O, and S; each X is independently selected from OH, PAr2, P(O)Ar2, OPAr2, C3-6 cycloalkyl, 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N, O, and S or each X together form O2PNR?2; Ar is C6-10aryl; and each R? is independently selected from hydrogen and C1-8 alkyl. Also provided are methods of making and using the compound of formula (I).
    Type: Application
    Filed: September 18, 2018
    Publication date: March 21, 2019
    Inventors: Pavel Nagorny, Siyuan Sun, Alonso Arguelles
  • GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
    Publication number: 20110229510
    Abstract: Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic peptide scaffolds that display carbohydrate antigens in a clustered fashion. The immunogenicity of select glycopeptide conjugates is demonstrated.
    Type: Application
    Filed: July 13, 2009
    Publication date: September 22, 2011
    Applicant: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: Samuel J. Danishefsky, Jianglong Zhu, Qian Wan, Insik Jeon, Woohan Kim, Pavel Nagorny, Dongjoo Lee, Philip Livingston, Govind Ragupathi