Patents by Inventor Pavel R. Badalov

Pavel R. Badalov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID FORMS OF A TOLL-LIKE RECEPTOR MODULATOR
    Publication number: 20230364092
    Abstract: The present disclosure provides crystalline forms, solvates and hydrates of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol, and methods of making.
    Type: Application
    Filed: December 13, 2022
    Publication date: November 16, 2023
    Inventors: Sylvie M. Asselin, Pavel R. Badalov, Henry G. Morrison, Christopher S. Regens, Tiago Vieira
  • METHODS OF PREPARING 1`-CYANO NUCLEOSIDES
    Publication number: 20230295214
    Abstract: The present disclosure generally describes methods of preparing 1?-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
    Type: Application
    Filed: February 10, 2023
    Publication date: September 21, 2023
    Inventors: Pavel R. Badalov, Stacy Bremner, Matthew R. Chin, Detian Gao, Nolan Griggs, Lars V. Heumann, Chiajen Lai, Robert R. Milburn, Sankar Mohan, Sean T. Neville, Bing Shi, Andrew C. Stevens, Nicholas A.J. Uhlig, Tiago Vieira, Todd A. Wenderski
  • Methods of preparing 1?-cyano nucleosides
    Patent number: 11613553
    Abstract: The present disclosure generally describes methods of preparing 1?-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: March 28, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Pavel R. Badalov, Stacy Bremner, Matthew R. Chin, Detian Gao, Nolan Griggs, Lars V. Heumann, Chiajen Lai, Robert R. Milburn, Sankar Mohan, Sean T. Neville, Bing Shi, Andrew C. Stevens, Nicholas A. J. Uhlig, Tiago Vieira, Todd A. Wenderski
  • Solid forms of a toll-like receptor modulator
    Patent number: 11583531
    Abstract: The present disclosure provides crystalline forms, solvates and hydrates of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol, and methods of making.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: February 21, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Sylvie M. Asselin, Pavel R. Badalov, Henry G. Morrison, Christopher S. Regens, Tiago Vieira
  • PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
    Publication number: 20220274985
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Application
    Filed: February 16, 2022
    Publication date: September 1, 2022
    Inventors: Andrea Ambrosi, Florence J. Bachrach, Pavel R. Badalov, Stephen P. Lathrop, Jeffrey E. Merit, Beau P. Pritchett, Christopher S. Regens, Tiago Vieira, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • Processes for preparing toll-like receptor modulator compounds
    Patent number: 11286257
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: March 29, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Andrea Ambrosi, Florence J. Bachrach, Pavel R. Badalov, Stephen P. Lathrop, Jeffrey E. Merit, Beau P. Pritchett, Christopher S. Regens, Tiago Vieira, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • METHODS OF PREPARING 1'-CYANO NUCLEOSIDES
    Publication number: 20210309689
    Abstract: The present disclosure generally describes methods of preparing 1?-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
    Type: Application
    Filed: March 11, 2021
    Publication date: October 7, 2021
    Inventors: Pavel R. Badalov, Stacy Bremner, Matthew R. Chin, Detian Gao, Nolan Griggs, Lars V. Heumann, Chiajen Lai, Robert R. Milburn, Sankar Mohan, Sean T. Neville, Bing Shi, Andrew C. Stevens, Nicholas A.J. Uhlig, Tiago Vieira, Todd A. Wenderski
  • PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
    Publication number: 20210017170
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Application
    Filed: June 25, 2020
    Publication date: January 21, 2021
    Inventors: Evangelos Aktoudianakis, Andrea Ambrosi, Sylvie M. Asselin, Florence J. Bachrach, Pavel R. Badalov, Gregory F. Chin, Stephen P. Lathrop, Willard Lew, Richard L. Mackman, Jeffrey E. Merit, Samuel E. Metobo, Michael R. Mish, Beau P. Pritchett, Hyung-Jung Pyun, Christopher S. Regens, Tiago Vieira, Xianghong Wang, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • SOLID FORMS OF A TOLL-LIKE RECEPTOR MODULATOR
    Publication number: 20200345738
    Abstract: The present disclosure provides crystalline forms, solvates and hydrates of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol, and methods of making.
    Type: Application
    Filed: April 15, 2020
    Publication date: November 5, 2020
    Applicant: Gilead Sciences, Inc.
    Inventors: Sylvie M. Asselin, Pavel R. Badalov, Henry G. Morrison, Christopher S. Regens, Tiago Vieira
  • SOLID FORMS OF A BET INHIBITOR
    Publication number: 20180141939
    Abstract: Forms of (2-cyclopropyl-6-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-4-yl)di(pyridin-2-yl)methanol (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I.
    Type: Application
    Filed: November 10, 2017
    Publication date: May 24, 2018
    Inventors: Olga Viktorovna Lapina, Ekaterina Albert, Pavel R. Badalov, Jinyu Shen