Patents by Inventor Pavitra Krishnaswamy

Pavitra Krishnaswamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10716485
    Abstract: A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the method employs a subspace-pursuit algorithm rooted in compressive sampling theory, performs a hierarchical search for sparse subcortical and cortical sources underlying the measurement, and estimates millisecond-scale currents in these sources to explain the data. The method can be used to recover thalamic and brainstem contributions to non-invasive M/EEG data, and to enable non-invasive study of fast timescale dynamical and network phenomena involving widespread regions across the human brain.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: July 21, 2020
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Pavitra Krishnaswamy, Patrick Purdon, Gabriel Obregon-Henao, Matti Hamalainen, Behtash Babadi
  • Patent number: 10646165
    Abstract: Systems and a method for reducing periodic artifacts in an electrophysiologic signal are provided. The method includes receiving a time-series electrophysiologic signal acquired from a subject and providing a regression model that defines an interference signal caused by periodic artifacts using a harmonic representation. The method also includes applying the regression model using the time-series electrophysiologic signal to define a cost function and performing an iterative optimization process to estimate regression parameters that minimize the cost function. The method further includes determining, using the regression parameters, the interference signal, and generating a corrected time-series electrophysiologic signal by reducing the interference signal.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: May 12, 2020
    Assignee: The General Hospital Corporation
    Inventors: Pavitra Krishnaswamy, Patrick L. Purdon, Emery N. Brown
  • Patent number: 10301587
    Abstract: Disclosed are methods and systems for subnanosecond rise time high voltage (HV) electric pulse delivery to biological loads. The system includes an imaging device and monitoring apparatus used for bio-photonic studies of pulse induced intracellular effects. The system further features a custom fabricated microscope slide having micro-machined electrodes. A printed circuit board to interface the pulse generator to the micro-machined glass slide having the cell solution is disclosed. An low-parasitic electronic setup to interface with avalanche transistor-switched pulse generation system is also disclosed. The pc-board and the slide are configured to match the output impedance of the pulse generator which minimizes reflection back into the pulse generator, and minimizes distortion of the pulse shape and pulse parameters. The pc-board further includes a high bandwidth voltage divider for real-time monitoring of pulses delivered to the cell solutions.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: May 28, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Pavitra Krishnaswamy, Andras Kuthi
  • Patent number: 9975249
    Abstract: A neuromuscular model-based controller for a robotic limb having at least one joint includes a neuromuscular model having a muscle model, muscle geometry and reflex feedback loop to determine at least one torque or impedance command to be sent to the robotic limb. One or more parameters that determine relation between feedback data and activation of the muscle model are adjusted consequent to sensory data from at least one of an intrinsic sensor and an extrinsic sensor. A controller in communication with the neuromuscular model is configured to receive the at least one torque or impedance command and controls at least one of position, torque and impedance of the robotic limb joint.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: May 22, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Hugh M. Herr, Ken Endo, Pavitra Krishnaswamy, Jared Markowitz, Michael Frederick Eilenberg, Jing Wang
  • Publication number: 20170332933
    Abstract: A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the method employs a subspace-pursuit algorithm rooted in compressive sampling theory, performs a hierarchical search for sparse subcortical and cortical sources underlying the measurement, and estimates millisecond-scale currents in these sources to explain the data. The method can be used to recover thalamic and brainstem contributions to non-invasive M/EEG data, and to enable non-invasive study of fast timescale dynamical and network phenomena involving widespread regions across the human brain.
    Type: Application
    Filed: November 9, 2015
    Publication date: November 23, 2017
    Inventors: Pavitra Krishnaswamy, Patrick Purdon, Gabriel Obregon-Henao, Matti Hamalainen, Behtash Babadi
  • Publication number: 20170096630
    Abstract: Disclosed are methods and systems for subnanosecond rise time high voltage (HV) electric pulse delivery to biological loads. The system includes an imaging device and monitoring apparatus used for bio-photonic studies of pulse induced intracellular effects. The system further features a custom fabricated microscope slide having micro-machined electrodes. A printed circuit board to interface the pulse generator to the micro-machined glass slide having the cell solution is disclosed. An low-parasitic electronic setup to interface with avalanche transistor-switched pulse generation system is also disclosed. The pc-board and the slide are configured to match the output impedance of the pulse generator which minimizes reflection back into the pulse generator, and minimizes distortion of the pulse shape and pulse parameters. The pc-board further includes a high bandwidth voltage divider for real-time monitoring of pulses delivered to the cell solutions.
    Type: Application
    Filed: October 31, 2016
    Publication date: April 6, 2017
    Applicant: University of Southern California
    Inventors: Pavitra Krishnaswamy, Andras Kuthi
  • Patent number: 9493765
    Abstract: Disclosed are methods and systems for subnanosecond rise time high voltage (HV) electric pulse delivery to biological loads. The system includes an imaging device and monitoring apparatus used for bio-photonic studies of pulse induced intracellular effects. The system further features a custom fabricated microscope slide having micro-machined electrodes. A printed circuit board to interface the pulse generator to the micro-machined glass slide having the cell solution is disclosed. An low-parasitic electronic setup to interface with avalanche transistor-switched pulse generation system is also disclosed. The pc-board and the slide are configured to match the output impedance of the pulse generator which minimizes reflection back into the pulse generator, and minimizes distortion of the pulse shape and pulse parameters. The pc-board further includes a high bandwidth voltage divider for real-time monitoring of pulses delivered to the cell solutions.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: November 15, 2016
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Pavitra Krishnaswamy, Andras Kuthi
  • Publication number: 20160207201
    Abstract: A neuromuscular model-based controller for a robotic limb having at least one joint includes a neuromuscular model having a muscle model, muscle geometry and reflex feedback loop to determine at least one torque or impedance command to be sent to the robotic limb. One or more parameters that determine relation between feedback data and activation of the muscle model are adjusted consequent to sensory data from at least one of an intrinsic sensor and an extrinsic sensor. A controller in communication with the neuromuscular model is configured to receive the at least one torque or impedance command and controls at least one of position, torque and impedance of the robotic limb joint.
    Type: Application
    Filed: December 22, 2015
    Publication date: July 21, 2016
    Inventors: Hugh M. Herr, Ken Endo, Pavitra Krishnaswamy, Jared Markowitz, Michael Frederick Eilenberg, Jing Wang
  • Publication number: 20160038091
    Abstract: Systems and a method for reducing periodic artifacts in an electrophysiologic signal are provided. The method includes receiving a time-series electrophysiologic signal acquired from a subject and providing a regression model that defines an interference signal caused by periodic artifacts using a harmonic representation. The method also includes applying the regression model using the time-series electrophysiologic signal to define a cost function and performing an iterative optimization process to estimate regression parameters that minimize the cost function. The method further includes determining, using the regression parameters, the interference signal, and generating a corrected time-series electrophysiologic signal by reducing the interference signal.
    Type: Application
    Filed: April 10, 2014
    Publication date: February 11, 2016
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Pavitra Krishnaswamy, Patrick L. Purdon
  • Patent number: 9221177
    Abstract: A neuromuscular model-based controller for a robotic limb having at least one joint includes a neuromuscular model having a muscle model, muscle geometry and reflex feedback loop to determine at least one torque or impedance command to be sent to the robotic limb. One or more parameters that determine relation between feedback data and activation of the muscle model are adjusted consequent to sensory data from at least one of an intrinsic sensor and an extrinsic sensor. A controller in communication with the neuromuscular model is configured to receive the at least one torque or impedance command and controls at least one of position, torque and impedance of the robotic limb joint.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: December 29, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Hugh M. Herr, Ken Endo, Pavitra Krishnaswamy, Jared Markowitz, Michael Frederick Eilenberg, Jing Wang
  • Publication number: 20130310979
    Abstract: A neuromuscular model-based controller for a robotic limb having at least one joint includes a neuromuscular model having a muscle model, muscle geometry and reflex feedback loop to determine at least one torque or impedance command to be sent to the robotic limb. One or more parameters that determine relation between feedback data and activation of the muscle model are adjusted consequent to sensory data from at least one of an intrinsic sensor and an extrinsic sensor. A controller in communication with the neuromuscular model is configured to receive the at least one torque or impedance command and controls at least one of position, torque and impedance of the robotic limb joint.
    Type: Application
    Filed: April 18, 2013
    Publication date: November 21, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Hugh M. Herr, Ken Endo, Pavitra Krishnaswamy, Jared Markowitz, Michael Frederick Eilenberg, Jing Wang
  • Publication number: 20080231337
    Abstract: Disclosed are methods and systems for subnanosecond rise time high voltage (HV) electric pulse delivery to biological loads. The system includes an imaging device and monitoring apparatus used for bio-photonic studies of pulse induced intracellular effects. The system further features custom fabricated microscope slide having micro-machined electrodes. A printed circuit board to interface the pulse generator to the micro-machined glass slide having the cell solution. An low-parasitic electronic setup to interface with avalanche transistor-switched pulse generation system. The pc-board and the slide are configured to match the output impedance of the pulse generator which minimizes reflection back into the pulse generator, and minimizes distortion of the pulse shape and pulse parameters. The pc-board further includes a high bandwidth voltage divider for real-time monitoring of pulses delivered to the cell solutions.
    Type: Application
    Filed: March 24, 2008
    Publication date: September 25, 2008
    Inventors: Pavitra Krishnaswamy, Andras Kuthi
  • Publication number: 20050050211
    Abstract: A method and apparatus to manage network addresses are described.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 3, 2005
    Inventors: Bharat Kaul, Narendra Tulpule, Mingcheng Zhu, Pavitra Krishnaswamy