Patents by Inventor Pavla Spacilova

Pavla Spacilova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, a soluble formulation of a pentacyclic or tetracyclic terpenoid and a pharmaceutical composition containing this soluble formulation
    Patent number: 8653056
    Abstract: The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a substituent selected from the group comprising substituents of general formula Xa bound to the hydroxy group of the terpenoid, wherein Xa is —OC—R—COOH, substituents of general formula Xa bound to the amino group of the terpenoid, wherein Xa is —OC—R—COOH, quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is —(CH2)nN+R3Y—, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je —(CH2)nR+Y—, substituents of general formula Xd bound to the carboxy group of the terpenoid, wherein Xd represents —R—COOH, glycosylic substituents Xe bound by alpha or beta glycosidic bond to the hydroxy group or to the carboxy group of the te
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: February 18, 2014
    Assignees: Univerzita Karlova V Praze, Prirodovedecka Fakulta, Univerzita Palackeho V Olomouci, I.Q.A., A.S.
    Inventors: Jan Sarek, Marian Hajduch, Michal Svoboda, Katerina Novakova, Pavla Spacilova, Tomas Kubelka, David Biedermann
  • Triterpenoid 2-deoxy Glycosides, Method of Preparation Thereof and Use Thereof as Medicaments
    Publication number: 20110218167
    Abstract: The invention describes novel triterpenoid 2-deoxy glycosides of general formula I, wherein at least one of the substituents X1 and R2 contains a 2-deoxy glycosidic group, method of preparation thereof, their cytotoxic activity and a pharmaceutical formulation containing these compounds.
    Type: Application
    Filed: November 6, 2009
    Publication date: September 8, 2011
    Inventors: Jan Sarek, Pavla Spácilová, Marian Hajduch