Patents by Inventor Pavlo Gilchuk

Pavlo Gilchuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210300999
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: March 25, 2021
    Publication date: September 30, 2021
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, JR., Seth ZOST, Robert CARNAHAN, Pavlo GILCHUK
  • Publication number: 20210277092
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: February 11, 2021
    Publication date: September 9, 2021
    Applicant: Vanderbilt University
    Inventors: James E. Crowe, JR., Seth Zost, Robert Carnahan, Pavlo Gilchuk
  • Patent number: 7435804
    Abstract: A bacterial high-expression system which is applicable for simultaneous screening of large numbers of recombinant clones from combinatorial antibody libraries is disclosed. The method pertains to screening of single chain antibodies from libraries expressed in the periplasm of E. coli by secretion. By this approach, approximately 104 clones can be screened in a single round. After screening, the clones, which express the recombinant antibodies to the desired antigen, can be directly used for production of large quantities of antibodies from microorganism culture. The system is especially attractive for fast screening of antibody libraries from a hybridoma source. A refolding method for the large-scale production of biologically active scFv-6 his proteins from bacterial inclusion bodies is also disclosed.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: October 14, 2008
    Assignee: Phage Biotechnology, Inc.
    Inventors: Vitaliy A. Kordyum, Oleg Okunev, Pavlo Gilchuk, Olena Deryabina, Dmitro Irodov
  • Publication number: 20060105389
    Abstract: A bacterial high-expression system which is applicable for simultaneous screening of large numbers of recombinant clones from combinatorial antibody libraries is disclosed. The method pertains to screening of single chain antibodies from libraries expressed in the periplasm of E. coli by secretion. By this approach, approximately 104 clones can be screened in a single round. After screening, the clones, which express the recombinant antibodies to the desired antigen, can be directly used for production of large quantities of antibodies from microorganism culture. The system is especially attractive for fast screening of antibody libraries from a hybridoma source. A refolding method for the large-scale production of biologically active scFv-6 his proteins from bacterial inclusion bodies is also disclosed.
    Type: Application
    Filed: October 19, 2004
    Publication date: May 18, 2006
    Inventors: Vitaliy Kordyum, Oleg Okunev, Pavlo Gilchuk, Olena Deryabina, Dmitro Irodov