Patents by Inventor Pawan Malhotra

Pawan Malhotra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimalarial compounds, process for preparation and their use for drug resistant malaria
    Patent number: 11365202
    Abstract: The present invention provides a new artemisinin-dipeptidyl vinyl based compound of Formula (I) or a pharmaceutically acceptable salt thereof and a process for the preparation thereof. The present invention further also provides a pharmaceutical composition comprising compounds of Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient to treat malaria.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: June 21, 2022
    Assignees: Council of Scientific and Industrial Research, International Centre for Genetic Engineering and Biotechnology (ICGEB)
    Inventors: Asish Kumar Bhattacharya, Eswar Kumar Aratikatla, Pawan Malhotra, Asif Mohmmed
  • NOVEL ANTIMALARIAL COMPOUNDS, PROCESS FOR PREPARATION AND THEIR USE FOR DRUG RESISTANT MALARIA
    Publication number: 20210101907
    Abstract: The present invention provides a new artemisinin-dipeptidyl vinyl based compound of Formula (I) or a pharmaceutically acceptable salt thereof and a process for the preparation thereof. The present invention further also provides a pharmaceutical composition comprising compounds of Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient to treat malaria.
    Type: Application
    Filed: April 16, 2019
    Publication date: April 8, 2021
    Inventors: Asish Kumar Bhattacharya, Eswar Kumar Aratikatla, Pawan Malhotra, Asif Mohmmed
  • Use of phosphono derivatives as anti-malarials
    Publication number: 20050171063
    Abstract: The invention provides the use of phosphono derivatives of selected aliphatic acids represented by the structural formulae R—COOH, R being PO3H2 or CR1R2—PO3H2 where R1/R2 are H, OH, COOH or alkyl groups for the treatment of malaria. The use of the compound comprises administering an effective amount of said compounds for in vitro and in vivo studies using malarial parasites (Plasmodium falciparum and Plasmodium berghei).
    Type: Application
    Filed: July 16, 2004
    Publication date: August 4, 2005
    Inventors: Pawan Malhotra, Palakodeti Dasaradhi, Asif Mohammed, Manzar Hossain, Sunil Mukherji, Venkatasamy Manivel, Kanury Subba Rao, Parameswaran Subrayan, Anil Chatterji
  • Use of selected amino acid-zinc complexes as anti-malarials
    Publication number: 20050090480
    Abstract: The invention provides the use of zinc complexes of selected amino acids from D or L isomers of proline, lysine, histidine, glycine, arginine and tryptophan or their various hydroxyl, amino, alkyl and carboxyl derivatives and zinc chloride, zinc acetate or other pharmacologically acceptable salts of zinc. The use of the compound comprises administering an effective amount of said compounds for inhibition of growth: of the malarial parasite, Plasmodium falciparum. The compound is lethal to the parasite in RBC cultures but have no effect on the RBCs. The compound has also displayed activity against, the chloroquine-resistant strain-W2Mef. The dose response curves for both 3D7 and W2Mef strains are identical which strongly suggested that the compound is equally effective against field isolates of chloroquine-resistant, P. falciparum. The compound acts on W2Mef strain through killing the target.
    Type: Application
    Filed: July 19, 2004
    Publication date: April 28, 2005
    Applicant: Council of Scientific & Industrial Research
    Inventors: Pawan Malhotra, Palakodeti Venkata Dasaradhi, Asif Mohammed, Manzar Hossain, Sunil Mukherji, Manivel Venkatasamy, Kanury Rao, Gyan Mishra, Parameswaran Subrayan, Anil Chatterji