Patents by Inventor Pawel A. Bialk

Pawel A. Bialk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR IMPROVING HOMOGENEITY OF DNA GENERATED USING A CRISPR/CAS9 CLEAVAGE SYSTEM
    Publication number: 20230091847
    Abstract: The invention relates to the unexpected discovery of a system and methods for precise homology directed repair after CRISPR/Cas9 cleavage. The invention includes a DNA cleavage and repair system comprising a CRISPR/Cas9 system and an oligonucleotide 100% complementary to cleaved DNA to promote homology directed DNA repair. The invention further includes methods for inducing homology directed repair of cleaved DNA and repairing a CRISPR/Cas9 cleavage.
    Type: Application
    Filed: July 6, 2022
    Publication date: March 23, 2023
    Applicant: Christiana Care Gene Editing Institute, LLC
    Inventors: Eric B. Kmiec, Pawel A. Bialk