Abstract: A compound having the following structure of Formula (I): or a stereoisomer of the compound, pharmaceutically acceptable salt, or tautomer thereof, wherein E, L, R3a, R3b, R3c, R3d, R5b, R8, Y1, Y2, Y3, Y4, Y5, Y6, X1, X2, Z1, and Z2 are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: A compound having the following structure of Formula (I): or a stereoisomer of the compound, tautomer of the compound, pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, A, X, Z, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: A method includes: receiving a first set of data associated with an element during a first stage of a plurality of stages; applying a first stage machine learning model to the first set of data to generate a prediction value, wherein the first stage machine learning model is trained with a first set of feature data that is available during the first stage; updating the prediction value by: receiving a second set of data associated with the element during a second stage of the plurality of stages; and applying a second stage machine learning model to the second set of data, wherein the second stage machine learning model is trained with (i) the first set of feature data, and (ii) a second set of feature data that is available during the second stage; and initiating performance of a mitigation action based on the updated prediction value.

Abstract: Assessing protection for storage resources, including: identifying a set of active data protection features for one or more storage resources; generating a data protection assessment based on the set of active data protection features; and reporting the data protection assessment.

Abstract: Audio and haptic signal processing systems and methods are provided. There is provided a method for haptic drive signal generation. The method comprises receiving an input audio signal for driving an audio speaker. The method further comprises deriving, from the audio signal, data components indicative of behaviour of the audio speaker when being driven by the input audio signal, each data component being associated with a respective frequency range. The method further comprises determining a haptic drive component from each data component. A gain is selected to provide to each of the haptic drive components, the gain being selected for each respective frequency range. Each selected gain is applied to the respective haptic drive component to produce gain adjusted haptic drive components.

Abstract: Described herein are—inter alia—complexes comprising a curcuminoid; and an anionic surfactant. Methods of making and using same are also described.

Abstract: The systems and methods disclosed herein receives artifacts generated using a first set of models within a multi-model superstructure. The multi-model superstructure includes a second set of models to test the first set of models. The multi-model superstructure dynamically routes the artifacts of the first set of models to one or more models of the second set of models by (i) determining a set of dimensions of the artifacts against which to evaluate the artifacts and (ii) identifying the models in the second set used to test the particular dimension. The second set of models then assesses each artifact against a set of assessment metrics. If an artifact fails to meet one or more assessment metrics, the second set of models generates actions to align the artifact with the set of assessment metrics.

Abstract: The invention provides a platform for evaluating and distributing packaged software capabilities. The packaged software capabilities described herein may be discrete pieces of software designed to perform a specific task and multiple packaged software capabilities may be combined to create larger functionality, such as an application. Packaged software capabilities may be analyzed using a variety of techniques to evaluate interoperability based on standard(s) to determine whether the packaged software capabilities support desired hardware, authentication, authorization, and the like. A catalog of packaged software capabilities satisfying the standard(s) may be created and the platform may provide a variety of techniques for searching the catalog based on search parameters to identify best fit packaged software capabilities meeting a user's needs.

Abstract: In one implementation, a method of displaying content is performed at a device including a display, one or more processors, and non-transitory memory. The method includes scanning a first physical environment to detect a first physical object in the first physical environment and a second physical object in the first physical environment, wherein the first physical object meets at least one first object criterion and the second physical object meets at least one second object criterion. The method includes displaying, in association with the first physical environment, a virtual object moving along a first path from the first physical object to the second physical object.

Abstract: Oral care compositions and methods for treating, preventing, or inhibiting dry mouth and/or inflammation of the oral cavity or a surface thereof are disclosed. Oral care compositions for improving oral care by treating, preventing, or otherwise inhibiting discomfort, irritation, or gum pain of the oral cavity are also disclosed. The oral care composition may include an orally acceptable vehicle, hyaluronic acid, and one or more benefit agents. The method for treating, preventing, or inhibiting dry mouth and/or inflammation of the oral cavity or a surface thereof may include contacting the oral cavity or the surface thereof with the oral care compositions.

Abstract: Methods are provided for treating a subject for an EGFRvIII expressing glioblastoma. The methods of the present disclosure involve administering to the subject a molecular circuit that is primed by EGFRvIII to induce one or more encoded therapeutics specific for one or more antigens expressed by the glioblastoma. Nucleic acids containing sequences encoding all or portions of such circuits are also provided, as well as cells, expression cassettes and vectors that contain such nucleic acids. Also provided are kits for practicing the described methods.

Abstract: The systems and methods disclosed herein enable mapping of gaps in controls to operative standards. The system receives an output generation request using an artificial intelligence (AI) model, where the input includes a set of gaps associated with one or more scenarios failing to satisfy the operative standards of a set of vector representations. Each gap in the set of gaps includes attributes defining the scenario. Using the received input, the system constructs prompts for each gap, where the prompts include information related to the scenario and/or the operative standards. Each prompt compares the corresponding gap against the operative standards or the set of vector representations. For each gap, the system maps the gap to the operative standards by supplying the prompt of the particular gap into the AI model and, in response, receiving from the AI model the operative standards associated with the particular gap.

Abstract: The systems and methods disclosed herein receive an output generation request from that includes input for generating an output using a language model. The input includes a set of alphanumeric characters associated with operative standards for a first set of actions. The system divides the set of alphanumeric characters into text subsets. For each text subset, a vector representation is determined. Prompts are created for each vector representation including the set of alphanumeric characters, query contexts, keywords, and/or the text subset. Each vector representation's prompt is input into the language model, which generates a second set of actions of related actions, where subsequently generated actions are based on prior generated actions. The system aggregates the second set of actions into a third set of actions and displays a graphical layout. The graphical layout displays a representation of the set of alphanumeric characters and the corresponding actions.

Abstract: An embodiment may involve storage containing incident logs and mappings between incident logs and vector representations generated by a machine learning (ML) model.

Abstract: Aspects of the present disclosure provide systems, methods, and computer-readable storage media that support configuration of cloud-based functionality. A configuration device is provided and includes a data processing module, a modelling module, and a loading module. The data processing module provides functionality for compiling information for use in configuring the cloud-based functionality in a requirements compliant manner. The modelling module may include various machine learning modules configured to evaluate configuration workbooks for compliance with requirements specified by a user. The modelling module may output recommendations for improving compliance of the configuration workbooks and appropriate changes may be made. The loading module may be configured to obtain templates applicable to the cloud-based functionality being configured and to extract appropriate data from the (updated) configuration workbooks.

Abstract: In one implementation, a method for recording an XR environment. The method includes: presenting, via the display device, a graphical environment with one or more virtual agents, wherein the graphical environment corresponds to a composition of extended reality (XR) content, including the one or more virtual agents, and an image stream of a physical environment captured from a first point-of-view (POV) of the physical environment; detecting, via the one or more input devices, a user input selecting a first virtual agent from among the one or more virtual agents; and in response to detecting the user input, recording a plurality of data streams associated with the graphical environment including a first image stream of the graphical environment from the first POV and one or more data streams of the graphical environment from a current POV of the first virtual agent.

Abstract: A device obtains a point cloud of a scene including a plurality of points. Each point has three-dimensional coordinates in a three-dimensional coordinate system. A first cluster of points has a first semantic label. The device obtains a two-dimensional image of the scene with a camera with an intrinsic parameter. The device detects, in the two-dimensional image, a representation of a first object corresponding to the first semantic label. The device determines two-dimensional coordinates in a two-dimensional coordinate system of the two-dimensional image corresponding to the first object. The device determines, from the first cluster of points, three-dimensional coordinates in the three-dimensional coordinate system of the scene corresponding to the two-dimensional coordinates in the two-dimensional coordinate system of the two-dimensional image of the scene. The device estimates the intrinsic parameter based on the two-dimensional and the three-dimensional coordinates.

Abstract: A computer-implemented system (“DeepXSOZ”) exploits synergy between deep-learning based spatial features and shallow-learning based expert knowledge encoding to identify Seizure Onset Zones based on spatiotemporal data captured during brain imaging. DeepXSOZ implements an independent component sorting technique that a) reduces expert sorting workload by 7-fold and b) enables the usage of rs-fMRI as a low-cost outpatient pre-surgical screening tool.

Abstract: In one implementation, a method of displaying content is performed at a device including a display, one or more processors, and non-transitory memory. The method includes scanning a first physical environment to detect a first physical object in the first physical environment and a second physical object in the first physical environment, wherein the first physical object meets at least one first object criterion and the second physical object meets at least one second object criterion. The method includes displaying, in association with the first physical environment, a virtual object moving along a first path from the first physical object to the second physical object.

Abstract: A light-weight radiation protection panel comprising radiation protection layer and a flexible material. The radiation protection layer comprises a plurality of a shielding material distributed in repeated and adjacent units of geometrical shapes, the light-weight radiation protection panel being able to be embodied in a wearable garment providing flexibility.