Patents by Inventor Pearlie K. Burnette

Pearlie K. Burnette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarkers for predicting response to immunosuppressive therapy
    Patent number: 9176122
    Abstract: The subject invention concerns methods and materials for assessing a patient's likelihood of responsiveness to an immunosuppressive therapy. The subject invention is contemplated for use with patients having an autoimmune disorder. In an exemplified embodiment, the methods of the invention are used for assessing and/or treating a patient with MDS. In one embodiment, a method of the invention comprises analyzing T cells of a patient for dysregulation of CD4+ and/or CD8+ T cell subsets, and determining the patient's likelihood of responsiveness to IST based on the level of dysregulation of the patient's CD4+ and/or CD8+ T cell subsets. In one embodiment, an increased likelihood of patient responsiveness to IST is associated with an increased percentage of CD4+ and/or CD8+ effector memory T cells and/or terminal effector memory T cells for a patient. The subject invention also concerns methods for treating a patient with an autoimmune disorder, such as MDS.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: November 3, 2015
    Assignees: UNIVERSITY OF SOUTH FLORIDA, UNITED STATES DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Pearlie K. Burnette
  • TELOMERASE REVERSE TRANSCRIPTASE DEFICIENCY AS DIAGNOSTIC MARKER OF MYELODYSPLASTIC SYNDROME
    Publication number: 20150005250
    Abstract: The subject invention pertains to methods and compositions for the detection and treatment of myelodysplastic syndromes based on impaired telomerase function.
    Type: Application
    Filed: October 15, 2012
    Publication date: January 1, 2015
    Inventors: Dana E. Rollison, Pearlie K. Burnette
  • BIOMARKERS FOR PREDICTING RESPONSE TO IMMUNOSUPPRESSIVE THERAPY
    Publication number: 20110091481
    Abstract: The subject invention concerns methods and materials for assessing a patient's likelihood of responsiveness to an immunosuppressive therapy. The subject invention is contemplated for use with patients having an autoimmune disorder. In an exemplified embodiment, the methods of the invention are used for assessing and/or treating a patient with MDS. In one embodiment, a method of the invention comprises analyzing T cells of a patient for dysregulation of CD4+ and/or CD8+ T cell subsets, and determining the patient's likelihood of responsiveness to IST based on the level of dysregulation of the patient's CD4+ and/or CD8+ T cell subsets. In one embodiment, an increased likelihood of patient responsiveness to IST is associated with an increased percentage of CD4+ and/or CD8+ effector memory T cells and/or terminal effector memory T cells, for a patient. The subject invention also concerns methods for treating a patient with an autoimmune disorder, such as MDS.
    Type: Application
    Filed: March 24, 2009
    Publication date: April 21, 2011
    Applicants: UNIVERSITY OF SOUTH FLORIDA, UNITED STATES DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Pearlie K. Burnette