Patents by Inventor Pedro A. Cohen

Pedro A. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
    Patent number: 5914254
    Abstract: The invention is directed to the use of a fusion partner that does not contain a leader sequence, as a means to increase the solubility and activity of recombinant polypeptides by facilitating the expression of fusion proteins, which are then transported out of the cytoplasm. The invention includes a nucleic acid encoding a fusion polypeptide comprising a mature interleukin-1-like polypeptide or a leader-deleted-translocating polypeptide, and a polypeptide of interest; as well as host cells comprising such nucleic acids, and fusion proteins so encoded. The invention also encompasses methods of using such nucleic acids to produce recombinant fusion polypeptides, mature polypeptides of interest, and purified compositions thereof.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: June 22, 1999
    Assignee: Celtrix Pharmaceuticals, Inc.
    Inventors: Desmond Mascarenhas, Yang Zhang, Pamela S. Olson, David R. Olsen, Pedro A. Cohen, Kimyen B. Nguyen
  • Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
    Patent number: 5629172
    Abstract: The invention is directed to the use of a fusion partner that does not contain a leader sequence, as a means to increase the solubility and activity of recombinant polypeptides by facilitating the expression of fusion proteins, which are then transported out of the cytoplasm. The invention includes a nucleic acid encoding a fusion polypeptide comprising a mature interleukin-1-like polypeptide or a leader-deleted-translocating polypeptide, and a polypeptide of interest; as well as host cells comprising such nucleic acids, and fusion proteins so encoded. The invention also encompasses methods of using such nucleic acids to produce recombinant fusion polypeptides, mature polypeptides of interest, and purified compositions thereof.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: May 13, 1997
    Assignee: Celtrix Pharmaceuticals, Inc.
    Inventors: Desmond Mascarenhas, Yang Zhang, Pamela S. Olson, David R. Olsen, Pedro A. Cohen