Patents by Inventor Pedro Alzari

Pedro Alzari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OB-fold used as scaffold for engineering new specific binders
    Patent number: 11434585
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: September 6, 2022
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Frédéric Pecorari, Pedro Alzari
  • OB-FOLD USED AS SCAFFOLD FOR ENGINEERING NEW SPECIFIC BINDERS
    Publication number: 20200181601
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Application
    Filed: January 24, 2020
    Publication date: June 11, 2020
    Inventors: Frédéric Pecorari, Pedro ALZARI
  • OB-fold used as scaffold for engineering new specific binders
    Patent number: 10584330
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: March 10, 2020
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Frederic Pecorari, Pedro Alzari
  • OB-FOLD USED AS SCAFFOLD FOR ENGINEERING NEW SPECIFIC BINDERS
    Publication number: 20170166887
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Application
    Filed: September 15, 2016
    Publication date: June 15, 2017
    Inventors: Frederic Pecorari, Pedro Alzari
  • OB-fold used as scaffold for engineering new specific binders
    Patent number: 9422548
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: August 23, 2016
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Frédéric Pecorari, Pedro Alzari
  • OB-Fold Used As Scaffold For Engineering New Specific Binders
    Publication number: 20160010083
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Application
    Filed: August 11, 2015
    Publication date: January 14, 2016
    Applicants: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Frédéric Pecorari, Pedro Alzari
  • Crystallographic structure of TcPRACA and uses therefor
    Publication number: 20130143201
    Abstract: A method of identifying a substance that affects the biological activity of a Trypanosome cruzi proline racemase (TcPRAC) protein comprises providing a purified TcPRAC protein, providing a substance to be tested, combining the TcPRAC protein with the substance, and determining the effect of the substance on the biological activity of the TcPRAC protein.
    Type: Application
    Filed: July 17, 2009
    Publication date: June 6, 2013
    Inventors: Paola Minoprio, Pedro Alzari, Alejandro Buschiazzo, Christophe Grégoire, Armand Berneman, Wim M. Degrave
  • Crystallographic structure of proline racemase and uses therefor
    Patent number: 8099245
    Abstract: The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: January 17, 2012
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Paola Minoprio, Pedro Alzari, Alejandro Buschiazzo, Wim Degrave, Christophe Gregoire, Nathalie Chamond, Armand Berneman
  • PEPTIDES OF IL-2
    Publication number: 20100273723
    Abstract: The present invention relates to new peptides of IL-2, derivatives thereof, and their use as therapeutic agents.
    Type: Application
    Filed: January 21, 2010
    Publication date: October 28, 2010
    Applicant: INSTITUT PASTEUR
    Inventors: Jacques Theze, Ralph Eckenberg, Jean-Louis Moreau, Michel Goldberg, Thierry Rose, Pedro Alzari, Jean-Claude Mazie
  • ACTIVE OR PASSIVE IMMUNIZATION AGAINST PROAPOPTOTIC NEUROTROPHINS FOR THE TREATMENT AND/OR PREVENTION OF NEURODEGENERATIVE DISEASES
    Publication number: 20100183645
    Abstract: The present invention relates to novel methods for combating cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammation as well as methods and means useful for said active or passive immunization.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 22, 2010
    Applicants: INSTITUT PASTEUR, INSTITUTO DE INVEST. BIO. CLEMENTE ESTABLE
    Inventors: Luis Hector Barbeito, Alvaro G. Estevez, Joseph S. Beckman, Mariana Pehar, Pedro Alzari, Maria Patricia Cassina
  • OB-FOLD USED AS SCAFFOLD FOR ENGINEERING NEW SPECIFIC BINDERS
    Publication number: 20100145008
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Application
    Filed: December 4, 2007
    Publication date: June 10, 2010
    Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Frederic Pecorari, Pedro Alzari
  • Method for inducing selected useful activities of IL-2 in a patient with peptides from IL-2
    Patent number: 7704490
    Abstract: The present invention relates to new peptides of IL-2, and derivatives thereof and their use as therapeutic agents.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: April 27, 2010
    Assignee: Institut Pasteur
    Inventors: Jacques Theze, Ralph Eckenberg, Jean-Louis Moreau, Michel Goldberg, Thierry Rose, Pedro Alzari, Jean-Claude Mazie
  • Method of inducing SHC phosphorylation of inducing the SHC/MAPK pathway by administering a peptide of IL-2
    Patent number: 7662368
    Abstract: The present invention relates to new peptides of IL-2, derivatives thereof, and their use as therapeutic agents.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: February 16, 2010
    Assignee: Institut Pasteur
    Inventors: Jacques Theze, Ralph Eckenberg, Jean-Louis Moreau, Michel Goldberg, Thierry Rose, Pedro Alzari, Jean-Claude Mazie
  • Crystallographic structure of TcPRACA and uses therefor
    Patent number: 7585656
    Abstract: The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: September 8, 2009
    Assignees: Institute Pasteur, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Paola Minoprio, Pedro Alzari, Alejandro Buschiazzo, Christophe Grégoire, Armand Berneman, Wim M. Degrave
  • Crystallographic Structure Of Tcpraca And Uses Therefor
    Publication number: 20080113422
    Abstract: The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.
    Type: Application
    Filed: June 1, 2004
    Publication date: May 15, 2008
    Inventors: Paola Minoprio, Pedro Alzari, Alejandro Buschiazzo, Wim Degrave, Christophe Gregoire, Nathalie Chamond, Armand Berneman
  • PknB kinase and pstP phosphatase and methods of identifying inhibitory substances
    Patent number: 7364856
    Abstract: The present invention relates to a pknB kinase and a pstP phosphatase as well as their use for identifying antibacterial substances.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: April 29, 2008
    Assignee: Institut Pasteur
    Inventors: Pedro Alzari, Brigitte Boitel, Andrea Villarino, Pablo Fernandez, Steward T. Cole
  • Pknb kinase and pstp phosphatase and methods of identifying inhibitory substances
    Publication number: 20070128678
    Abstract: The present invention relates to a pknB kinase and a pstP phosphatase as well as their use for identifying antibacterial substances.
    Type: Application
    Filed: July 19, 2004
    Publication date: June 7, 2007
    Applicant: INSTITUT PASTEUR
    Inventors: Pedro Alzari, Brigitte Boitel, Andrea Villarino, Pablo Fernandez, Stewart Cole
  • Peptides of IL-2
    Publication number: 20070048302
    Abstract: The present invention relates to new peptides of IL-2, derivatives thereof, and their use as therapeutic agents.
    Type: Application
    Filed: July 28, 2006
    Publication date: March 1, 2007
    Applicant: INSTITUT PASTEUR
    Inventors: Jacques Theze, Ralph Eckenberg, Jean-Louis Moreau, Michel Golberg, Thierry Rose, Pedro Alzari, Jean-Claude Mazie
  • Active or passive immunization against proapoptotic neurotrophins for the treatment and/or prevention of neurodegenerative diseases
    Publication number: 20060275290
    Abstract: The present invention relates to novel methods for combating cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammation as well as methods and means useful for said active or passive immunization.
    Type: Application
    Filed: January 24, 2006
    Publication date: December 7, 2006
    Applicants: INSTITUT PASTEUR, INSTITUTO DE INVEST. BIO. CLEMENTE ESTABLE
    Inventors: Luis Barbeito, Alvaro Estevez, Joseph Beckman, Mariana Pehar, Pedro Alzari, Maria Cassina
  • Peptides of IL-2
    Patent number: 7101965
    Abstract: The present invention relates to new peptides of IL-2, derivatives thereof, and their use as therapeutic agents.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: September 5, 2006
    Assignee: Institut Pasteur
    Inventors: Jacques Theze, Ralph Eckenberg, Jean-Louis Moreau, Michel Goldberg, Thierry Rose, Pedro Alzari, Jean-Claude Mazie