Abstract: The present invention relates to a novel class of pyridine-sulfonamide compounds and to compositions comprising the same. The compounds and compositions are useful as medicaments in the treatment of diseases responsive to inhibition of IL-1?, such as non-alcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis (IPF).

Abstract: The present invention relates to a novel class of tetrahydroisoquinoline compounds of formula I and to compositions comprising the same. The compounds and compositions of the present invention can be used as medicaments in the treatment of cancer.

Abstract: p38 and JNK mitogen activated protein (MAP) kinase al losteric inhibitors are useful for treatment and/or prophylaxis of degenerative diseases of the nervous system. Compounds are used in a method for treatment and/or prophylaxis of the diseases and for use in therapy in general. The compounds bind to the region composed of amino acids at positions 170-199 of Mitogen-activated protein kinase 14 (Uniprot accession nr Q16539 or SEQ ID No 1) and/or Mitogen-activated protein kinase 11 (Uniprot accession nr Q15759 or SEQ ID No 2), SEQ ID NO.1 and SEQ ID NO.2 being the amino acid sequences of MAPK14 (?38?) and MAPK11 (?38?), respectively. The specific region composed of amino acids at positions 170-199 is herein disclosed as SEQ ID HO.4 for Mitogen-activated protein kinase 14 and SEQ ID NO.5 for Mitogen-activated protein kinase 11 and are believed to be new inhibitory binding sites.

Abstract: The present invention provides new p38 mitogen activated protein (MAP) kinase allosteric inhibitors which are useful for the treatment of p38 mediated diseases such as inflammatory diseases, e.g. rheumatoid arthritis, osteoarthritis, psoriatic arthritis, pain, musculoskeletal system inflammation and musculoskeletal system aging. The present invention thus provides compounds for use in a method for treatment of inflammatory diseases, as well as for use in therapy in general, wherein the compound binds to the region composed of amino acids at positions 170-199 of Mitogen-activated protein kinase 14 (Uniprot accession nr Q16539 or SEQ ID No 1) and/or Mitogen-activated protein kinase 11 (Uniprot accession nr Q15759 or SEQ ID No 2), SEQ ID NO. 1 and SEQ ID NO. 2 being the amino acid sequences of MAPK14 (p38cx) and MAPK11 (p38?), respectively. The specific region composed of amino acids at positions 170-199 is herein disclosed as SEQ ID NO. 4 for Mitogen-activated protein kinase 14 and SEQ ID NO.

Abstract: A manually propelled cart for the removal of snow, with dual function as garden cart, comprising: a PVC framework with handles on its upper segment, and a scoop on its lower segment. The framework supported by a rectangular metallic plate adhered to its underside, disposed on top of two large wheels in the middle of its length, with an axle attached to the plate's underside providing the cart a seesaw motion. A pivoted scoop designed as a rectangular bin, with an open forward section and an axle attached to its bottom underside, rotates in a vertical plane. A latch mechanism disposed adjacent the scoop's rearwall, controls its automatic motions and is operated by pulling a cable connected to a handle. Two springs hooked to the scoop's sidewalls and to the supporting plate acting cooperatively with the latch. Two swivel casters underside the plate's forward end, makes the cart steerable.

Abstract: Lower ecologic and visual impact, associated with high energy production, is the main goals of this invention The device is a motionless inert structure (5) with 2 to 6 lateral openings (1) with large area of exposure to fluids that direct the fluid from any direction (omnidirectional) and promotes a Venturi effect which speeds up towards a smaller highly efficient turbine (2) that operates with a higher RPM. The system operates with two combined flow streams (7,8,9,10,11,12) that enhance the energy generated by the turbine. The whole structure is scalable to the area available, needs required and can be installed in buildings to be built from scratch, already constructed buildings (if provided minimum area available at the top) and also on mountains/country fields/sea, etc. This invention is applicable in the energy industry, being able to sub-markets for micro generation as well as large power plants.

Abstract: The present invention relates to an energy absorbing element intended to absorb the impact energy on vehicle doors constituted by a structure in hollow prismatic cells delimited by two bases parallel to their longitudinal axes, manufactured by extrusion, which results in a continuous piece from which by means of cutting the energy absorption element is obtained with a projection adapted to the form of the area to be protected. The disposition of the hollow prismatic cells is transversal to the direction of the force of the impact resulting in an energy absorption behaviour very close to optimal. The use of foams is also envisaged which allow the response curve of the absorbing element to be adapted without requiring the use of different extrusion dies.