Patents by Inventor Pedro E. Hernandez-Abad

Pedro E. Hernandez-Abad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of IB-MECA
    Patent number: 9102698
    Abstract: The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: August 11, 2015
    Assignee: CAN-FITE BIOPHARMA LTD.
    Inventors: Paul Bruzinski, Xuejun Liu, Cameron Gibb, Pedro E. HErnandez-Abad
  • Process for and intermediates in the preparation of canfosfamide and its salts
    Patent number: 8334266
    Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: December 18, 2012
    Assignee: Telik, Inc.
    Inventors: William A. Boulanger, Steven J. Collier, Stephen A. Eastham, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernandez Abad, R. Jason Herr, Hans J. Kjaersgaard, Harold Meckler, Robert E. Polomski, Steven R. Schow, Pavel E. Zhichkin
  • PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS
    Publication number: 20120238772
    Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
    Type: Application
    Filed: March 23, 2012
    Publication date: September 20, 2012
    Inventors: William A. Boulanger, Steven J. Collier, Stephen A. Eastham, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernández Abad, R. Jason Herr, Hans J. Kjaersgaard, Harold Meckler, Robert E. Polomski, Steven R. Schow, Pavel E. Zhichkin
  • Process for and intermediates in the preparation of canfosfamide and its salts
    Patent number: 8198247
    Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: June 12, 2012
    Assignee: Telik, Inc.
    Inventors: William A. Boulanger, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernandez Abad, R. Jason Herr, Harold Meckler, Steven R. Schow, Pavel E. Zhichkin
  • PROCESS FOR THE SYNTHESIS OF IB-MECA
    Publication number: 20100087636
    Abstract: The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.
    Type: Application
    Filed: March 13, 2008
    Publication date: April 8, 2010
    Inventors: Paul Bruzinski, Xuejun Liu, Cameron Gibb, Pedro E. Hernandez-Abad
  • Antiviral compounds
    Patent number: 5817807
    Abstract: Macrocyclic compounds having 1, 4, 8, 11-tetraazacyclotetradecanyl group, show good selectivity against HIV-1 and HIV-2, in in vitro tests are disclosed.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: October 6, 1998
    Assignee: Anormed Inc.
    Inventors: Gary J. Bridger, Sreenivasan Padmanabhan, Renato T. Skerlj, Pedro E. Hernandez-Abad, Milind P. Sant