Abstract: In one embodiment, the disclosure includes an air-based geothermal cooling system for a telecom utility cabinet. The air-based geothermal cooling system includes a plurality of heat exchange tubes configured to extend into an underground environment. The air-based geothermal cooling system also includes an input/output (I/O) manifold coupled to the plurality of heat exchange tubes and providing an airway between the plurality of heat exchange tubes and the telecom utility cabinet.

Abstract: In one embodiment, the disclosure includes a telecom utility cabinet including a heat load chamber. The telecom utility cabinet also includes an air introducing duct configured to conduct air from the heat load chamber to a geothermal cooling system. The telecom utility cabinet also includes an air discharging duct configured to conduct air from the geothermal cooling system to the heat load chamber. In another embodiment, the disclosure includes a method for managing temperature in a telecom utility cabinet. The method includes introducing air from a heat load chamber to a geothermal cooling system and discharging air from the geothermal cooling system to the heat load chamber.

Abstract: The present invention discloses a double transgenic fly that expresses both Tau protein and the human A?42 peptide of human amyloid-? precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either Tau or human A?42 alone, and thus provide for an improved model for neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying for therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.

Abstract: Embodiments of a storage cabinet and methods for making and using such cabinet are disclosed. In one embodiment of an apparatus. a tubular sealed chamber for storing telecommunications equipment is coupled to a sealed chamber to support the sealed chamber. The tubular sealed chamber comprises at least one mount configured to attach and remove the telecommunications equipment, a tube and at least one door to enclose one end of the tube. The support structure partially surrounds the sealed chamber and an area between the sealed chamber and the support structure defines an inter-tube space that functions as a thermal barrier.

Abstract: The present invention provides methods, compositions and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.

Abstract: Embodiments of tubular telecommunications cabinets are presented herein. Specifically, Telecommunications equipment cabinets are described which are configured to protect a plurality of components from environmental influences and provide a high degree of access to the interior of the cabinet. In an implementation a cabinet is configured with a plurality of mountings to mount a plurality of telecommunications equipment within a tubular enclosure. A plurality of partially-tubular sides may be joined to form the tubular enclosure around the mountings. Thus, equipment may be mounted within the cabinet to protect the equipment, for instance, at an outside location. The sides further are operable to permit access to the interior and corresponding equipment around substantially the entire perimeter of the cabinet.

Abstract: A heat exchanger having a wet side separate from a dry side for an equipment cabinet is provided. The heat exchanger includes a heat exchanger enclosure having a wet side fan and a dry side fan. The wet side fan draws air in from the external environment and routes the air through a heat exchanger core and out the heat exchanger enclosure. The dry side fan draws air in from within the equipment cabinet and routes the air through the heat exchanger core and out back into the equipment cabinet. The air from the outside acts to cool the heat exchanger core, which in turn acts to cool the air from the dry side as the air is routed through the heat exchanger core.

Abstract: The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.

Abstract: Embodiments of tubular telecommunications cabinets are presented herein.

Abstract: Embodiments of a storage cabinet and methods for making and using such a cabinet are presented herein.

Abstract: An air-to-air heat exchanger is simply and easily installed in an electronics cabinet in the field by using a template to form an air exit opening that corresponds with an air inlet opening of the heat exchanger, and an air inlet opening that corresponds with an air exit opening of the heat exchanger. Once the openings have been formed, the heat exchanger is mounted to the outside of the cabinet, such as on a side wall or a door of the cabinet.

Abstract: The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.

Abstract: The present invention discloses a double transgenic fly that expresses both Tau protein and the human A?42 peptide of human amyloid-? precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either Tau or human A?42 alone, and thus provide for an improved model for neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying for therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.

Abstract: The present invention discloses a double transgenic fly that expresses both human Tau protein and the human A&bgr;42 peptide of human amyloid-&bgr; precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either human Tau or human A&bgr;42 alone. Thus, the flies provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.

Abstract: A fuel flowmeter has a flowmeter with rotating impellers with meshed lobes rotatable in partially cylindrical housings joined in a case having an inlet at one side and an outlet at an opposite side. Fuel moves in the inlet filling voids between lobes in both impellers and moves cylindrically around opposite partially cylindrical walls and turning the impellers until reaching the outlet. Flow conditioners in the inlet and outlet allows smooth flow, reducing turbulence and promoting lamellar flow into and out of the case. One of the rotors may have a magnetic marker. A transmitter with a Hall effect sensor is mounted on the case. A signal conditioning software is connected to the Hall effect sensor for adjusted transmitted information according to measured pulse rate and a standard flow.

Abstract: The present invention relates to Drosophila models of the neurodegenerative disorder spinocerebellar ataxia 1 (SCA-1). In particular, the invention relates to transgenic Drosophila which express normal human ataxin-1 or mutant human ataxin-1 with expanded polyglutamine repeats for SCA-1 therapeutics. The invention further relates to the diagnosis of predispositions to developing SCA-1. The invention further relates to methods of using the transgenic Drosophila to screen for therapeutics of SCA-1 and other neurodegenerative disorders. The invention further relates to the identification of modifier genes of the SCA-1 phenotypes produced by overexpression of ataxin-1, for therapeutic and diagnostic uses and for screening for therapeutics of SCA-1 and other neurodegenerative disorders. The invention further relates to the diagnosis of a predisposition to SCA-1 comprising detecting the overexpression of normal ataxin-1.

Abstract: The present invention provides compositions, methods and kits for the detection of genetic polymorphisms or mutations related to dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphism or mutations generally occur in the dihydropyrimidine dehydrogenase DPD gene in chromosome 1. Also provided are mutant forms of DPD.

Abstract: A jewelry rope chain having a double helix appearance formed from a plurality of interlaced links or rings of wire is disclosed. Each link is made from a wire loop having a gap, wherein the wire loop has a cross-section with a major axis defining a long diametrical dimension and a minor axis defining a short diametrical dimension. The long diametrical dimension is disposed in a plane defined by a diameter of the link and the short diametrical dimension is perpendicular to the long diametrical dimension. A ratio of the long diametrical dimension to the short diametrical dimension is less than 1.3:1. The gap of the wire loop is narrower than the long diametrical dimension of the loop cross-section.

Abstract: The invention relates to methods and compositions that are useful for detecting deficiencies in dihydropyrimidine dehydrogenase (DPD) levels in mammals including humans. Cancer patients having a DPD deficiency are at risk of a severe toxic reaction to the commonly used anticancer agent 5-fluorouracil (5-FU). Claimed are DPD genes from human and pig, methods for detecting the level of nucleic acids that encode DPD in a patient, and nucleic acids that are useful as probes for this purpose. Also claimed are methods for expressing DPD in heterologous organisms. Expression vectors that employ a DPD nucleic acid as a selectable marker are also claimed. This selectable marker functions in both prokaryotes and eukaryotes.

Abstract: The invention relates to methods and compositions that are useful for detecting deficiencies in dihydropyrimidine dehydrogenase (DPD) levels in mammals including humans. Cancer patients having a DPD deficiency are at risk of a severe toxic reaction to the commonly used anticancer agent 5-fluorouracil (5-FU). Claimed are DPD genes from human and pig, methods for detecting the level of nucleic acids that encode DPD in a patient, and nucleic acids that are useful as probes for this purpose. Also claimed are methods for expressing DPD in heterologous organisms. Expression vectors that employ a DPD nucleic acid as a selectable marker are also claimed. This selectable marker functions in both prokaryotes and eukaryotes.