Patents by Inventor Pedro Fernandez-Salguero

Pedro Fernandez-Salguero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR DETECTING DIHYDROPYRIMIDINE DEHYDROGENASE SPLICING MUTATIONS
    Publication number: 20090280537
    Abstract: The present invention provides methods, compositions and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.
    Type: Application
    Filed: June 16, 2008
    Publication date: November 12, 2009
    Applicant: The Government of USA as Represented by the Secret ary of the Department of Health and Human Service
    Inventors: Frank J. Gonzalez, Pedro Fernandez-Salguero
  • Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
    Patent number: 7402387
    Abstract: The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: July 22, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frank J. Gonzalez, Pedro Fernandez-Salguero
  • Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
    Publication number: 20050136433
    Abstract: The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.
    Type: Application
    Filed: August 3, 2004
    Publication date: June 23, 2005
    Inventors: Frank Gonzalez, Pedro Fernandez-Salguero
  • Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
    Patent number: 6787306
    Abstract: The present invention provides compositions, methods and kits for the detection of genetic polymorphisms or mutations related to dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphism or mutations generally occur in the dihydropyrimidine dehydrogenase DPD gene in chromosome 1. Also provided are mutant forms of DPD.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: September 7, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frank J. Gonzalez, Pedro Fernandez-Salguero
  • Cloning and expression of cDNA for human dihydropyrimidine dehydrogenase
    Patent number: 6015673
    Abstract: The invention relates to methods and compositions that are useful for detecting deficiencies in dihydropyrimidine dehydrogenase (DPD) levels in mammals including humans. Cancer patients having a DPD deficiency are at risk of a severe toxic reaction to the commonly used anticancer agent 5-fluorouracil (5-FU). Claimed are DPD genes from human and pig, methods for detecting the level of nucleic acids that encode DPD in a patient, and nucleic acids that are useful as probes for this purpose. Also claimed are methods for expressing DPD in heterologous organisms. Expression vectors that employ a DPD nucleic acid as a selectable marker are also claimed. This selectable marker functions in both prokaryotes and eukaryotes.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: January 18, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frank J. Gonzalez, Pedro Fernandez-Salguero
  • CDNA for human and pig dihydropyrimidine dehydrogenase
    Patent number: 5856454
    Abstract: The invention relates to methods and compositions that are useful for detecting deficiencies in dihydropyrimidine dehydrogenase (DPD) levels in mammals including humans. Cancer patients having a DPD deficiency are at risk of a severe toxic reaction to the commonly used anticancer agent 5-fluorouracil (5-FU). Claimed are DPD genes from human and pig, methods for detecting the level of nucleic acids that encode DPD in a patient, and nucleic acids that are useful as probes for this purpose. Also claimed are methods for expressing DPD in heterologous organisms. Expression vectors that employ a DPD nucleic acid as a selectable marker are also claimed. This selectable marker functions in both prokaryotes and eukaryotes.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: January 5, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frank J. Gonzalez, Pedro Fernandez-Salguero