Patents by Inventor Pedro J. Del Nido
Pedro J. Del Nido has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931023Abstract: A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.Type: GrantFiled: February 18, 2021Date of Patent: March 19, 2024Assignee: Children's Medical Center CorporationInventors: Pedro J. del Nido, Nikolay V. Vasilyev, Franz Freudenthal
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Publication number: 20240041595Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: ApplicationFiled: July 13, 2023Publication date: February 8, 2024Applicant: The Children's Medical Center CorporationInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Mossab Y. Saeed
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Publication number: 20230416413Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.Type: ApplicationFiled: September 1, 2023Publication date: December 28, 2023Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
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Publication number: 20230211045Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.Type: ApplicationFiled: September 1, 2022Publication date: July 6, 2023Applicants: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Publication number: 20230183380Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.Type: ApplicationFiled: October 6, 2022Publication date: June 15, 2023Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
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Patent number: 11627949Abstract: An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.Type: GrantFiled: February 4, 2020Date of Patent: April 18, 2023Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
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Publication number: 20230039350Abstract: Method and devices for viewing one or more valve leaflets via a viewer. In some embodiments the viewer includes a body having a first end and a second end opposite the first end, the first end being closed and having a transparent viewing window, the second end arranged to be attached to an aorta or a pulmonary artery, and one or more ports arranged to provide fluid access to an internal portion of the viewer to pressurize the one or more leaflets. A diameter of the viewing window is larger than an outer diameter of the second end. An outer diameter of the first end of the body is larger than an outer diameter of the second end. The body is a tubular body.Type: ApplicationFiled: January 22, 2021Publication date: February 9, 2023Applicant: Children's Medical Center CorporationInventors: Peter E. Hammer, Ignacio Berra, David Hoganson, Pedro J. del Nido, Douglas P. Perrin
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Publication number: 20220395531Abstract: This disclosure pertains to pharmaceutical compositions of aerosolized compositions containing mitochondria, methods of preparing and using the compositions, and devices for administering the compositions.Type: ApplicationFiled: April 15, 2020Publication date: December 15, 2022Inventors: James D. McCully, Pedro J. Del Nido
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Publication number: 20220347212Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating or preventing disorders or damage associated with ischemia-reperfusion injury (IRI) using such compositions.Type: ApplicationFiled: October 30, 2019Publication date: November 3, 2022Inventors: James D. McCully, Pedro J. del Nido
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Patent number: 11433161Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.Type: GrantFiled: January 11, 2021Date of Patent: September 6, 2022Assignees: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Publication number: 20210346014Abstract: A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.Type: ApplicationFiled: February 18, 2021Publication date: November 11, 2021Inventors: Pedro J. del Nido, Nikolay V. Vasilyev, Franz Freudenthal
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Publication number: 20210322170Abstract: A repair device for closing a valve of a heart includes a main stem. The mains stem has a distal end and a proximal end. The main stem comprises a papillary anchor on the proximal end. The papillary anchor of the main stem is configured to attach to a papillary muscle of the heart. The main stem further includes a first branch extending from the main stem in a first direction and configured to attach to a first leaflet of the valve of the heart. The main stem also includes a second branch extending from the main stem in a second direction different from the first direction and configured to attach to a second leaflet of the valve. The first and second branches are flexible.Type: ApplicationFiled: July 11, 2019Publication date: October 21, 2021Inventors: Peter E. Hammer, David Hoganson, Mossab Y. Saeed, Pedro J. Del Nido, Christopher W. Baird, Sitaram M. Emani
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Patent number: 11097090Abstract: Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly, at appropriate times. For example, the device may be implanted within the right ventricle, anchored to the right ventricular free wall and the ventricular septum. The device may function to bring the opposing walls of the ventricle toward one another, synchronized with the pacing of the heart, resulting in an improved ejection fraction of blood from the chamber. In some embodiments, the actuator includes a bladder that is configured to contract upon receiving an inflow of pressurized fluid therein. When the fluid exits therefrom, the bladder relaxes back to an initial, extended state.Type: GrantFiled: March 28, 2018Date of Patent: August 24, 2021Assignees: President and Fellows of Harvard College, Children's Medical Center CorporationInventors: Nikolay V. Vasilyev, Pedro J. del Nido, Tonatiuh M. Lievano Beltran, Erik A. Kraus, Nikhil Mehandru, Evelyn J. Park, Conor J. Walsh, Isaac Wamala, Markus Horvath
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Publication number: 20210238534Abstract: An automated isolation device for isolation of mitochondria includes an incubation station including a holder for a viable mitochondria solution; and a cooling system, controlled by a processor of the device, for cooling the holder. The device includes a processor-controlled transfer system for transferring solution from the holder to a filtration station; and the filtration station, including a series of filters. The device includes a processor-controlled spectrometry station including a spectrometer positioned to illuminate a cuvette fluidically coupled to an output of the filtration station; and a detector coupled to the processor and positioned on a side of the cuvette opposite the spectrometer. The device includes a processor-controlled transfer system for transferring solution from the spectrometry station to a centrifuge. The centrifuge is processor-controlled and configured to centrifuge the filtrate to separate viable mitochondria from a supernatant.Type: ApplicationFiled: May 8, 2019Publication date: August 5, 2021Inventors: James D. McCully, Douglas B. Cowan, Pedro J. Del Nido, Thomas Duignan
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Patent number: 11065036Abstract: An instrument port for introducing instruments into a surgical site, including a port body having a channel running therethrough from a proximal end to a distal end, an instrument sleeve in slidable contact with the channel, creating a gap therebetween, and fluid flow for removing emboli efficiently from the instrument port, wherein the fluid flow includes the gap is provided. A fluid flow system for use in an instrument port is provided. A method of removably securing an instrument sleeve to a port body by anchoring the instrument port to heart tissue, making at least one flood line in a channel, flushing out emboli, and performing surgery with the instrument port.Type: GrantFiled: September 18, 2015Date of Patent: July 20, 2021Assignees: Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Christopher DiBiasio, Keith Durand, Jonathan Brigham Hopkins, Zach Traina, Alexander Slocum, Samir Nayfeh, Pedro J. del Nido, Nikolay V. Vasilyev
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Publication number: 20210205492Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.Type: ApplicationFiled: January 11, 2021Publication date: July 8, 2021Applicants: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Patent number: 10966826Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: GrantFiled: November 16, 2018Date of Patent: April 6, 2021Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
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Patent number: 10905795Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the outer element.Type: GrantFiled: February 16, 2017Date of Patent: February 2, 2021Assignees: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Publication number: 20200368017Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: ApplicationFiled: November 16, 2018Publication date: November 26, 2020Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
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Publication number: 20200360135Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: ApplicationFiled: June 2, 2020Publication date: November 19, 2020Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne