Patents by Inventor Pedro J. Del Nido

Pedro J. Del Nido has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10905795
    Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the outer element.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: February 2, 2021
    Assignees: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
  • Publication number: 20200368017
    Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.
    Type: Application
    Filed: November 16, 2018
    Publication date: November 26, 2020
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
  • Publication number: 20200360135
    Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.
    Type: Application
    Filed: June 2, 2020
    Publication date: November 19, 2020
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
  • Publication number: 20200337524
    Abstract: A device for performing intervention procedures includes an elongated body having a first end and a second end. The elongated body includes a hollow tool channel extending through the elongated body from the first end to the second end. The tool channel is configured to receive an intervention tool and a length-adjusting element disposed at the first end or the second end of the elongated body. The length-adjusting element is configured to enable a length of the elongated body to be adjusted. The elongated body includes an angle-adjusting element disposed along the length of the elongated body. The angle-adjusting element is configured to enable the elongated body to be bent . The device includes an imaging system disposed at the first end or the second end of the elongated body. The imaging system includes an imaging device and an illumination device.
    Type: Application
    Filed: November 7, 2018
    Publication date: October 29, 2020
    Inventors: Mossab Y. Saeed, Pedro J. Del Nido, Nikolay V. Vasilyev, Niv Ad, Christopher J. Payne
  • Patent number: 10736626
    Abstract: A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: August 11, 2020
    Assignee: Children's Medical Center Corporation
    Inventors: Pedro J. del Nido, Nikolay V. Vasilyev, Franz Freudenthal
  • Publication number: 20200179050
    Abstract: An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.
    Type: Application
    Filed: February 4, 2020
    Publication date: June 11, 2020
    Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
  • Publication number: 20200123273
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Application
    Filed: June 25, 2019
    Publication date: April 23, 2020
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • Patent number: 10588695
    Abstract: An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: March 17, 2020
    Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
  • Publication number: 20200054785
    Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the outer element.
    Type: Application
    Filed: February 16, 2017
    Publication date: February 20, 2020
    Applicants: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Eric N. Feins, Pedro J del Nido, Nikolay V Vasilyev, Haruo Yamauchi, Douglas P Perrin, Peter Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D O'Cearbhaill
  • Patent number: 10478290
    Abstract: An expandable valve (100) and valve frame device that may be implanted within the body, for example, at a position of the heart. The device may be surgically implanted and subsequently expanded at a later time. The device may include an expandable sewing member (160) surrounding the valve frame (130) at a region between upstream and downstream ends of the device, for attaching the device to surrounding tissue. The device may include a membrane (140) for blocking leakage out the side of the valve frame between opposite ends. However, the membrane may include a side opening (170) for guiding fluid flow toward an appropriate anatomical outflow tract. The device may include a hood-like covering attached to a tissue wall, for smoothly receiving and guiding fluid flow along a perpendicular bend. The device may further include a flared opening at a downstream end, providing adequate space for device attachment.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: November 19, 2019
    Assignee: Children's Medical Center Corporation
    Inventors: Sitaram Emani, James E. Lock, Pedro J. del Nido, Audrey C. Marshall
  • Patent number: 10420645
    Abstract: A device for treating tricuspid regurgitation includes a shaft and a first fixation mechanism disposed on a distal end of the shaft. The first fixation mechanism is configured to anchor the device to a first cardiac tissue. The device includes a second fixation mechanism disposed on a proximal end of the shaft. The second fixation mechanism is configured to anchor the device to a second cardiac tissue. The device includes an approximation mechanism connecting the first fixation mechanism and the second fixation mechanism, wherein the approximation mechanism causes the second fixation mechanism to move along the shaft toward the first fixation mechanism to approximate the first cardiac tissue and the second cardiac tissue.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: September 24, 2019
    Assignees: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Pedro J. Del Nido, Haruo Yamauchi, Nikolay V. Vasilyev, Maria Jose M. Nunes Pereira, Eoin D. O'Cearbhaill
  • Patent number: 10370458
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: August 6, 2019
    Assignees: Children's Medical Center Corporation and Beth Israel, Deaconess Medical Center, Inc.
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • Publication number: 20190183486
    Abstract: A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.
    Type: Application
    Filed: April 8, 2016
    Publication date: June 20, 2019
    Inventors: Pedro J. del Nido, Nikolay V. Vasilyev, Franz Freudenthal
  • Publication number: 20180318484
    Abstract: Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly, at appropriate times. For example, the device may be implanted within the right ventricle, anchored to the right ventricular free wall and the ventricular septum. The device may function to bring the opposing walls of the ventricle toward one another, synchronized with the pacing of the heart, resulting in an improved ejection fraction of blood from the chamber. In some embodiments, the actuator includes a bladder that is configured to contract upon receiving an inflow of pressurized fluid therein. When the fluid exits therefrom, the bladder relaxes back to an initial, extended state.
    Type: Application
    Filed: March 28, 2018
    Publication date: November 8, 2018
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Nikolay V. Vasilyev, Pedro J. Del Nido, Tonatiuh M. Lievano Beltran, Erik A. Kraus, Nikhil Mehandru, Evelyn J. Park, Conor J. Walsh, Isaac Wamala, Markus Horvath
  • Publication number: 20180057610
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Application
    Filed: November 3, 2017
    Publication date: March 1, 2018
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • Patent number: 9844394
    Abstract: The instrument ports for introducing instruments into a surgical site that are disclosed herein include a port body having a channel running therethrough from a proximal end to a distal end, an instrument sleeve in slidable contact with the channel, creating a gap therebetween, and a fluid flow element for removing emboli efficiently from the instrument port, wherein the fluid flow element includes the gap. Disclosed fluid flow systems are for use in the disclosed instrument ports. Methods are also disclosed for removably securing an instrument sleeve to a port body by anchoring the instrument port to heart tissue, making at least one flood line in a channel, flushing out emboli, and performing surgery with the instrument port.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: December 19, 2017
    Assignees: Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Christopher DiBiasio, Keith Durand, Jonathan Brigham Hopkins, Zach Traina, Alexander Slocum, Samir Nayfeh, Pedro J. del Nido, Nikolay V. Vasilyev
  • Publication number: 20170231477
    Abstract: An instrument port for introducing an instrument into a surgical site includes a port body, a bulb disposed on the distal end of the port body, and a channel extending from a proximal end to a distal end of the instrument port. The channel includes an instrument channel defined in the port body and a bulb channel defined in the bulb. An imaging system is disposed at or near the distal end of the instrument port. The imaging system is fluidically isolated from the surgical site.
    Type: Application
    Filed: February 10, 2017
    Publication date: August 17, 2017
    Inventors: Pedro J. del Nido, Nikolay V. Vasilyev
  • Publication number: 20170079717
    Abstract: An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.
    Type: Application
    Filed: May 13, 2015
    Publication date: March 23, 2017
    Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
  • Publication number: 20170020516
    Abstract: A tissue clip for adjoining tissues including a body portion, a biasing mechanism interconnecting the body portion to a tissue grasping mechanism, the grasping mechanism having a first condition wherein the grasping mechanism is extending against and away from the body portion and a second condition wherein the grasping mechanism is biased against the body portion. A tissue clip and deployer combination. A method of interconnecting tissue by deploying the tissue clip, puncturing tissue to be interconnected with the tissue clip, and interconnecting the tissue. A method of treating an aneurism by deploying the tissue clip at an aneurism site, closing off the aneurism site with the tissue clip, and treating the aneurism. A method of imaging a surgical procedure with ultrasound by modifying a surface of a metal surgical instrument, and imaging the metal surgical instrument with ultrasound during a surgical procedure.
    Type: Application
    Filed: April 8, 2016
    Publication date: January 26, 2017
    Inventors: Pedro J. del Nido, Nikolay V. Vasilyev, Franz Freudenthal
  • Publication number: 20170014228
    Abstract: An expandable valve (100) and valve frame device that may be implanted within the body, for example, at a position of the heart. The device may be surgically implanted and subsequently expanded at a later time. The device may include an expandable sewing member (160) surrounding the valve frame (130) at a region between upstream and downstream ends of the device, for attaching the device to surrounding tissue. The device may include a membrane (140) for blocking leakage out the side of the valve frame between opposite ends. However, the membrane may include a side opening (170) for guiding fluid flow toward an appropriate anatomical outflow tract. The device may include a hood-like covering attached to a tissue wall, for smoothly receiving and guiding fluid flow along a perpendicular bend. The device may further include a flared opening at a downstream end, providing adequate space for device attachment.
    Type: Application
    Filed: November 26, 2014
    Publication date: January 19, 2017
    Applicant: Children's Medical Center Corporation
    Inventors: Sitaram Emani, James E. Lock, Pedro J. del Nido, Audrey C. Marshall