Patents by Inventor Pedro M. Alzari

Pedro M. Alzari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Post-translationally modified neurotrophin antibodies
    Patent number: 9328163
    Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that bind to these modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: May 3, 2016
    Assignees: INSTITUT PASTEUR, INSTITUTO DE INVESTIGACIONES BIOLOGICAS CLEMENTE ESTABLE, FACULTAD DE MEDICINA, UNIVERSIDAD DE LA REPUBLICA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Luis Barbeito, Mariana Pehar, Patricia Cassina, Pedro M. Alzari
  • POST-TRANSLATIONALLY MODIFIED NEUROTROPHINS
    Publication number: 20140178384
    Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
    Type: Application
    Filed: September 26, 2013
    Publication date: June 26, 2014
    Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FACULTAD DE MEDICINA UNIVERSIDAD DE LA REPUBLICA, INSTITUTO DE INVESTIGACIONES SIOL. CLEM. ESTASLE
    Inventors: Luis BARBEITO, Mariana Pehar, Patricia Cassina, Pedro M. Alzari
  • POST-TRANSLATIONALLY MODIFIED NEUROTROPHINS
    Publication number: 20100055109
    Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving a chronic pain and/or neuron loss.
    Type: Application
    Filed: July 23, 2007
    Publication date: March 4, 2010
    Applicants: Institut Pasteur, Instituto De Investigaciones Biol. Clem. Estable, Facultad De Medicina, Universidad De La Republica, Centre National De La Recherche Scientifique
    Inventors: Luis Barbeito, Mariana Pehar, Patricia Cassina, Pedro M. Alzari