Abstract: The present disclosure provides an apparatus and method for the production of center-filled confectionery pieces. The apparatus includes an extruder, a feedback system, and a forming device. The feedback system ensures that a strand of center-filled confectionery produced by the extruder has a substantially uniform size when the strand enters the forming device. The forming device forms the strand into center-filled confectionery pieces having 15%-25% by weight of a center-fill material without producing leakers.

Abstract: The present invention is directed to a S-nitrosothiol derivative of penicillamine or glutathione, of formula I: or its pharmaceutically acceptable salt thereof, in which: A and B are independently phenyl groups or together form the group —CH2—Q—CH2—constituting a six membered ring in which Q represents oxygen, sulfur, or a group N—R3, in which R3 is hydrogen or a C1-C4 alkyl group; R1 is an acyl group, which may be an aliphatic C1-C5 acyl group or an acyl group of glutamic acid bonded via its gamma carboxyl group; R2 is a hydroxyl group or a glycine group bonded via a peptide bond; with the proviso that if R1 is an aliphatic acyl group, then R2 is a hydroxyl group, and if R1 is a glutamic acid, then R2 is a glycine group. The compounds have vasodilating activity and inhibit the aggregation of the platelets which make them useful for the treatment of dysfunctions of the circulating system, especially at the cardiovascular level.

Abstract: Novel S-nitrosothiols derivatives of penicillamine or glutathione, which correspond to following general formula(I) 1