Abstract: The present disclosure relates to methods of treating tumors and cancers having dysregulated Wnt signaling pathways with compounds of Formula (I) having the following structure: (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where X is a halogen and R is a phenyl substituted with a perfluoroalkane. Also disclosed is a method of treating a tumor, which involves contacting a tumor comprising cytoplasmic EZH2 with a kinase inhibitor compound under conditions effective to treat the tumor.

Abstract: Disclosed herein are embodiment relating to a methods of obtaining a functionalized porous or fibrous solid substrate with the chemical and/or physical properties of a nano-structured molecular or polymer chemical compound that contains it. In accordance with some example embodiments, the properties of the starting substrate may be modified to obtain a new functionalized substrate. The new substrate may have various applications, such as, for example, an optical- and/or fluorescent-type chemical sensor, as a chemical sequestrator, or as a modifier of the properties of a surface, making it, for example, superhydrophobic.

Abstract: An electric nerve stimulation device and apparatus for suppressing organic pain and other functional disorders of the nervous system without noxious sensation and substantially free from the adaptation phenomenon which usually results from subjecting receptors and nerve cells to uniform stimulating signals. The device includes a pulse generator to produce bipolar rectangular waveforms at preselected repetition rate and of a preselected width during a given first time period. Electronic circuits are connected to the post generator to deliver rectangular waveforms at a repetition rate which is chosen by a pseudo-random function for a second time period which is also chosen by a pseudo-random function. Further circuitry is provided to inhibit delivery of pulse waves for a third period of time. This third period of time is chosen by a pseudo-random function, thereby substantially eliminating noxious sensations and adaptation of nerve cells to stimulation during suppression of the organic pain.