Patents by Inventor Pedro R. Collazo

Pedro R. Collazo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the isolation and expression of a gene which codes for streptokinase, nucleotide sequence obtained, recombinant DNA and transformed microorgnaisms
    Patent number: 5296366
    Abstract: The present invention relates to the field of biotechnology and genetic engineering and in particular a novel nucleotide sequence which codes for a streptokinase, as well as the recombinant DNA obtained therefrom which is used for the transformation of various host organisms.The present invention is based on the isolation of a new gene which codes for streptokinase from Streptococcus equisimilis of type C (strain ATCC-9542) and the cloning and expression thereof in prokaryotic (E. coli) and eukaryotic (Pichia pastoris) hosts, for which it includes the vehicles of expression which contain the genetic sequences of said gene, as well as the microorganisms transformed with these vectors capable of producing streptokinase.The protein obtained thereby can be used in clinical medicine as a therapeutic agent, in the treatment of disorders such as thromboembolic obstructions including coronary thrombosis.
    Type: Grant
    Filed: May 22, 1991
    Date of Patent: March 22, 1994
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Mario P. E. Garcia, Aimee P. Felipe, Roger R. Chaplen, Ricardo S. Doce, Luciano F. H. Marrero, Pedro R. Collazo, Anaisel C. Ramirez, Emilio A. M. Munoz, Walfrido B. Martinez, Magalys C. Somavilla, Alicia P. Fernandez, Jose d. d. Garcia, Luis S. H. Martinez