Patents by Inventor Pedro R. Lowenstein

Pedro R. Lowenstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene
    Patent number: 8883493
    Abstract: Compositions and methods useful in transgene expression are provided. Herpes simplex virus type 1 thymidine kinase sequences (“TK sequences”) are used to enhance transgene expression in first generation and high capacity adenoviral vectors. An mCMV promoter-driven ?-galactosidase-expressing cassette is combined with TK sequences through direct fusion of the cDNA's. ?-galactosidase (transgene) expression is enhanced independent of adenoviral vector selection. Methods of enhancing transgene expression employing the inventive adenoviral vectors are provided, along with pharmaceutical preparations comprising the inventive vectors and kits for enhanced transgene expression.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: November 11, 2014
    Assignee: Cedars-Sinai Medical Center
    Inventors: Pedro R. Lowenstein, Maria Castro
  • ADENOVIRAL VECTOR COMPRISING HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE AND A TRANSGENE FOR INCREASING THE EXPRESSION OF THE TRANSGENE
    Publication number: 20100143304
    Abstract: Compositions and methods useful in transgene expression are provided. Herpes simplex virus type 1 thymidine kinase sequences (“TK sequences”) are used to enhance transgene expression in first generation and high capacity adenoviral vectors. An mCMV promoter-driven ?-galactosidase-expressing cassette is combined with TK sequences through direct fusion of the cDNA's. ?-galactosidase (transgene) expression is enhanced independent of adenoviral vector selection. Methods of enhancing transgene expression employing the inventive adenoviral vectors are provided, along with pharmaceutical preparations comprising the inventive vectors and kits for enhanced transgene expression.
    Type: Application
    Filed: January 30, 2008
    Publication date: June 10, 2010
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Pedro R. Lowenstein, Maria Castro