Abstract: The present invention provides a method of quantifying the activity of a protein modifying enzyme in a sample, comprising calculating the value K for said protein-modifying enzyme on the basis of the number of modified peptides in a sample that are substrates of said protein modifying enzyme, the intensity of the modified peptides, each modified peptide in the sample that is a substrate of said protein modifying enzyme, the total number of modified peptides in the sample, the intensity of the modified peptides and all of the modified peptides in the sample. A method of quantifying the activity of a protein modifying enzyme in a sample, comprising calculating the value SC for said protein-modifying enzyme on the basis of a reduction in proliferation using an inhibitor at an inhibitor concentration at which proliferation is measured and the “in vitro” IC50i of the inhibitor against a primary target is also provided.

Abstract: An antenna module comprises: stacked printed circuit boards (PCBs) (stacked PCBs) centered on an axis and including: a first PCB having a ground plane; a second PCB, spaced above the first PCB, having a first radiator pair and a second radiator pair that face the ground plane and orthogonally crisscross each other at the axis, each radiator pair having respective signal and ground connection pads adjacent to the axis to form a coincident phase center at the axis for each radiator pair; a third PCB, spaced above the second PCB, for impedance matching; and signal connectors extending through the first PCB; and support PCBs extending from the ground plane to the second PCB, the support PCBs having microstrip feeds to connect the respective signal and ground connection pads of the first radiator pair and the second radiator pair to the signal connectors and to the ground plane.

Abstract: The present disclosure relates to a calibration device, a calibration setup, and a calibration method for measuring a radio frequency (RF) signal generator. The calibration device comprises an input configured to receive an RF signal of the RF signal generator, wherein the RF signal is output for the purpose of calibration and has discrete frequency lines. The calibration device further comprises a mixer configured to mix the RF signal with a first local oscillator (LO) signal and a second LO signal. The mixing may comprise a logical AND combination of the RF and LO signals, and obtains an intermediated frequency (IF) signal. The IF signal has discrete frequency lines and has a smaller bandwidth than the RF signal.

Abstract: The invention relates generally to cancer treatments involving an epigenetic agent which promotes the effectiveness of a kinase inhibitor.

Abstract: A method of reducing mechanical vibrations of a motor system including an electric motor, the method including: a) receiving a vibration-related signal based on measurements by one or more sensors mounted on the electric motor, b) generating a reactive torque reference based on the vibration-related signal, and c) controlling the electric motor based on the reactive torque reference and a main torque reference to counteract the mechanical vibrations.

Abstract: A method of identifying parameters of a motor system having an electric motor assembly and a control system, for vibration reduction in the electric motor assembly, the method including: a) sweeping a frequency of an oscillating reactive torque injected into the electric motor, b) determining a natural frequency of the motor system, the natural frequency being the frequency at which the oscillating reactive torque produces a maximum amplitude of a vibration-related parameter obtained based on vibration-related measurements by sensors mounted to the electric motor, c) incrementally increasing a magnitude of reactive torque oscillating at the natural frequency, injected to the electric motor, d) obtaining a magnitude of the vibration-related parameter for each magnitude of the reactive torque injected in step c), and e) determining, for each magnitude of the injected reactive torque, a gain and a phase response of the motor system, the gain being determined based on the magnitude of the injected reactive torque

Abstract: A field of electric drive devices and electric machines, such as electric motors and electric generators for industrial applications and more particularly to a method and an arrangement for controlling vibration of a variable frequency drive controlled electric machine. In the method for controlling vibration of a variable frequency drive controlled electric machine, the resonance frequency/frequencies and the stiffness are determined in a ramp up/ramp down test; amount of damping is determined in an impulse test; a mechanical transfer function is determined in a steady drive test; a vibration control model is determined utilizing said resonance frequency/frequencies, said stiffness, the amount of damping and the mechanical transfer function; and vibration is controlled utilizing the vibration control model.

Abstract: In some aspects, the techniques described herein relate to an apparatus including: a ground plane element including: a non-conductive support layer, a conductive layer arranged on the non-conductive support layer, and at least one orifice through the non-conductive support layer and the conductive laminate layer; one or more radiating elements including a feed line and a solder pad, wherein each of the one or more radiating elements is secured to and electrically connected to the ground plane element via soldering of the solder pad to the conductive laminate layer; and at least one connector arranged in the at least one orifice and electrically connected to the feed line.

Abstract: Methods are provided for predicting the efficacy of midostaurin for the treatment of a cancer in an individual subject or a cohort of patients. The method comprises determining a phosphoproteomic and/or a proteomic signature within a sample obtained from the individual subject wherein the phosphoproteomic and/or proteomic signature provides a personalised prediction for the individual subject of the efficacy of midostaurin for treatment of cancer. This invention has utility in methods for treatment of a range of cancers including acute myeloid leukaemia (AML). Companion diagnostic kits and their use in dosage regimens for the treatment of cancer are also provided.

Abstract: A method of identifying a fault in a synchronous reluctance electric machine, the method including carrying out a first vibration measurement on a stator in a first radial direction of the stator; carrying out a second vibration measurement on the stator in a second radial direction of the stator; determining, on the basis of at least one of the first vibration measurement and the second vibration measurement, a first vibration frequency; determining, on the basis of the first vibration measurement and the second vibration measurement, a mode shape of the vibration at the first vibration frequency; and determining, on the basis that the first vibration frequency fb and the mode shape m fulfil the following barrier fault conditions: fb=fr, and m=1 where fr is a rotation frequency of a rotor, that a flux barrier of the rotor is defect.

Abstract: The present invention provides a computer-implemented method of identifying a drug with which to y treat a patient, the method comprising the steps of : a. providing a dataset of expression values of biological markers from a sample taken from said patient; b. using said dataset of expression values to calculate a plurality of drug response distance values Dn for each of a plurality of drugs dn, wherein D for each drug d is the difference between the distribution of expression of biological markers of sensitivity to drug d relative to the distribution of expression of biological markers of resistance to drug d; c.

Abstract: A method of identifying a fault in a synchronous reluctance electric machine, the method including carrying out a first vibration measurement on a stator in a first radial direction of the stator; carrying out a second vibration measurement on the stator in a second radial direction of the stator; determining, on the basis of at least one of the first vibration measurement and the second vibration measurement, a first vibration frequency; determining, on the basis of the first vibration measurement and the second vibration measurement, a mode shape of the vibration at the first vibration frequency; and determining, on the basis that the first vibration frequency fb and the mode shape m fulfil the following barrier fault conditions: fb=fr, and m=1 where fr is a rotation frequency of a rotor, that a flux barrier of the rotor is defect.

Abstract: A field of electric drive devices and electric machines, such as electric motors and electric generators for industrial applications and more particularly to a method and an arrangement for controlling vibration of a variable frequency drive controlled electric machine. In the method for controlling vibration of a variable frequency drive controlled electric machine, the resonance frequency/frequencies and the stiffness are determined in a ramp up/ramp down test; amount of damping is determined in an impulse test; a mechanical transfer function is determined in a steady drive test; a vibration control model is determined utilizing said resonance frequency/frequencies, said stiffness, the amount of damping and the mechanical transfer function; and vibration is controlled utilizing the vibration control model.

Abstract: A method and device of determining a fault condition in a synchronous motor including a rotor provided with damper bars and an end ring to which the damper bars are mechanically connected thereby forming a damper cage, wherein the method includes: obtaining a first measurement of an end ring current from a first location along the end ring, processing the first measurement to thereby obtain a processing result, and determining whether a fault condition is present in the synchronous motor based on the processing result.

Abstract: A method for preventing a frequency component of a voltage from occurring in an electrical machine including the steps of: obtaining, either by measuring a voltage signal or a current signal from the electrical machine in time domain and transforming the measured signal into frequency domain, by simulating or deducing a first frequency component present in the electrical machine in absence of a grounding, the first frequency component representing a first undesired frequency higher than a limit frequency of 500 Hz; and providing the electrical machine with a first grounding at a grounding location, the first grounding including a resonant circuit resonating at the first undesired frequency. In order to get rid of harmful shaft voltages in the form of sharp voltage peaks at high frequencies, it is first necessary to determine at which undesired frequency or frequencies these voltage peaks occur.

Abstract: A method of performing de-excitation of a brushless synchronous machine having a stator; and a rotor including: a field winding, an exciter armature, a rectifier having thyristors, the rectifier having input terminals connected to the exciter armature and output terminals connected to the field winding, a field discharge resistor connected in series with the field winding, and a bypass switch connected in parallel with the field discharge resistor, the bypass switch being operable between a closed state in which the field discharge resistor is bypassed, and an open state, wherein the method including: a) controlling the thyristors to fire only during a negative half-cycle of the armature voltage waveforms, and b) controlling the bypass switch to obtain the open state from the closed state to thereby discharge a field winding current through the field discharge resistor.

Abstract: The present invention provides a method of quantifying the activity of a protein modifying enzyme in a sample, comprising calculating the value K for said protein-modifying enzyme on the basis of the number of modified peptides in a sample that are substrates of said protein modifying enzyme, the intensity of the modified peptides, each modified peptide in the sample that is a substrate of said protein modifying enzyme, the total number of modified peptides in the sample, the intensity of the modified peptides and all of the modified peptides in the sample. A method of quantifying the activity of a protein modifying enzyme in a sample, comprising calculating the value SC for said protein-modifying enzyme on the basis of a reduction in proliferation using an inhibitor at an inhibitor concentration at which proliferation is measured and the “in vitro” IC50i of the inhibitor against a primary target is also provided.

Abstract: A method for detecting a fault in an AC/AC exciter having an exciter rotor and an exciter stator. A signal reflecting the current or voltage, is obtained at an exciter rotor winding or at an exciter stator winding. A frequency analysis is applied and on the basis of a presence of a frequency component, a rotor current or voltage signal, at a first frequency fs*(2?s), where fs is a supply frequency of the exciter stator and s is an exciter slip, it is determined whether the exciter suffers from an inter-turn short circuit in an exciter stator winding or not. On the basis of a presence of a frequency component, in the case of a stator current signal or a stator voltage signal, at a second frequency fs*(1?2*s), it is determined whether the exciter suffers from an inter-turn short circuit in an exciter rotor winding or not. Presence of frequency components at the first and/or second frequencies in windings of an AC/AC exciter indicate the mentioned fault conditions.

Abstract: A robot system includes: a robot arm having a plurality of links and joints by which one of the links is connected to another; sensors for determining, for any one of the joints, an angular velocity of the joint and a torque to which the joint is subject; a neural network connected to the sensors, the neural network receiving therefrom angular velocity and torque data, the neural network being trained to distinguish, based on the angular velocity and torque data, between a normal operation condition of the robot arm, a condition in which the robot arm collides with an outside object, and a condition where a person deliberately interacts with the robot arm; and a controller for controlling motion of the robot arm, a mode of operation of which is variable depending on an operation condition signal output by the neural network. One operation mode is a leadthrough mode.