Abstract: The present invention relates to combination therapies employing FAP-targeted CD40 agonists, in particular bispecific antigen binding molecules comprising at least one antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP) and at least one antigen binding domain capable of specific binding to CD40, and radiotherapy.

Abstract: Example implementations relate to generating virtualized network functions by identifying mappable elements and unmappable elements of a virtualized network function template based on a network function virtualization model. The mappable elements may be mapped to the network function virtualization model. The mappable elements may be translated based on the mapping. The unmappable elements are filtered based on a black-white list. The translated virtualized network function definition comprising the translated elements and the filtered elements is generated. The virtualized network function is generated based on the translated virtualized network function definition.

Abstract: The present invention relates to an in vitro cell culture method comprising a step of contacting T-cells with an MPC inhibitor, and further to a cell population comprising T-cells with a memory phenotype obtained by said method, preferably, wherein the T-cells are human cells. The present invention also relates to a method for generating and/or maintaining T-cells and/or B-cells with a memory phenotype comprising the steps of culturing T-cells and or B-cells in vitro and adding an MPC inhibitor to the culture. The invention furthermore relates to a population of T-cells and/or B-cells obtained by the methods of the invention. Also provided are immunotherapies using the cells of the invention. Furthermore, provided is an MPC inhibitor for use in immunotherapy and/or as a vaccine co-adjuvant.

Abstract: The present invention relates to an in vitro cell culture method comprising a step of contacting T-cells with an IDH2 inhibitor, and further to a cell population comprising T-cells with a memory phenotype obtained by said method, preferably, wherein the T-cells are human cells. The present invention also relates to a method for generating and/or maintaining T-cells and/or B-cells with a memory phenotype comprising the steps of culturing T-cells and/or B-cells in vitro and adding an IDH2 inhibitor to the culture. The invention furthermore relates to a population of T-cells and/or B-cells obtained by the methods of the invention. Also provided are immunotherapies using the cells of the invention. Furthermore, provided is an IDH2 inhibitor for use in immunotherapy.

Abstract: Example implementations relate to generating virtualized network functions by identifying mappable elements and unmappable elements of a virtualized network function template based on a network function virtualization model. The mappable elements may be mapped to the network function virtualization model. The mappable elements may be translated based on the mapping. The unmappable elements are filtered based on a black-white list. The translated virtualized network function definition comprising the translated elements and the filtered elements is generated. The virtualized network function is generated based on the translated virtualized network function definition.

Abstract: Gellan gum-based hydrogels are disclosed herein for in vitro cell culture and tissue engineering and regenerative medicine applications. Such gellan gum-based hydrogels may be used alone or combined with live cells and/or biomolecules for application in humans and/or animals. Chemical modification of gellan gum with selected ion-chelating substituents affords novel gellan gum hydrogels endowed with tunable physicochemical and biological properties. The modified gellan gum hydrogels described herein present advantages over existing hydrogel systems, including solubility, ionic crosslinking versatility, ease of formulation and injectability and greater adhesiveness within biological tissues and surfaces, whilst maintaining encapsulated cells viable during long culture periods and up-regulating the expression of healthy extracellular matrix markers.

Abstract: Example implementations relate to generating virtualized network functions by identifying mappable elements and unmappable elements of a virtualized network function template based on a network function virtualization model. The mappable elements may be mapped to the network function virtualization model. The mappable elements may be translated based on the mapping. The unmappable elements are filtered based on a black-white list. The translated virtualized network function definition comprising the translated elements and the filtered elements is generated. The virtualized network function is generated based on the translated virtualized network function definition.

Abstract: The present disclosure relates to gellan gum and gellan gum-based hydrogels (GG-based hydrogels) for promoting chondrogenic, osteogenic and adipogenic differentiation of human mesenchymal stem cells, preferentially osteogenic. The present disclosure also relates to a composition for use in bone, cartilage and soft tissue engineering and regenerative medicine, preferably for use in bone.

Abstract: An arthroscopic surgery device for delivering a therapeutic formulation into a cartilage of an articular joint, wherein the device comprises: a flexible tubular delivery arm, comprising one or more internal channels for carrying the therapeutic formulation; a flexible external sleeve enveloping the delivery arm lengthwise; a pliable cup attached to an end of the delivery arm, for covering a cartilage part where the therapeutic formulation is to be delivered, arranged such that by outwards axial displacement of the delivery arm in respect to the external sleeve, the cup moves from inside to outside of the external sleeve, expanding the cup. The device may comprise a flexible internal sleeve between the delivery arm and the external sleeve, such that the flexible internal sleeve envelops the delivery arm lengthwise. The arthroscopic surgery device may be also used for extracting fluid from an articular cavity.

Abstract: The invention discloses a method for selecting a human patient for CD73 antagonist therapy, preferably immunotherapy, comprising the step of determination in a patient's biological sample, that lymphocytes, preferably CD4+ T cells, express CD73, wherein, upon a determination that lymphocytes, preferably CD4+ T cells, express CD73 in patient's biological sample, the patient is declared sensitive to immunotherapy using an antagonist of CD73, preferably an anti-CD73 antibody. Combined therapy with immunotherapy against an inhibitory ICP and/or with a chemotherapeutic agent sensitive to MDR1 exclusion activity is proposed.

Abstract: Gellan gum-based hydrogels are disclosed herein for in vitro cell culture and tissue engineering and regenerative medicine applications. Such gellan gum-based hydrogels may be used alone or combined with live cells and/or biomolecules for application in humans and/or animals. Chemical modification of gellan gum with selected ion-chelating substituents affords novel gellan gum hydrogels endowed with tunable physicochemical and biological properties. The modified gellan gum hydrogels described herein present advantages over existing hydrogel systems, including solubility, ionic crosslinking versatility, ease of formulation and injectability and greater adhesiveness within biological tissues and surfaces, whilst maintaining encapsulated cells viable during long culture periods and up-regulating the expression of healthy extracellular matrix markers.

Abstract: The present disclosure relates to gellan gum and gellan gum-based hydrogels (GG-based hydrogels) for promoting chondrogenic, osteogenic and adipogenic differentiation of human mesenchymal stem cells, preferentially osteogenic. The present disclosure also relates to a composition for use in bone, cartilage and soft tissue engineering and regenerative medicine, preferably for use in bone.

Abstract: There is described an ulvan containing composition. This composition is a viscosupplement composition and can be used in the treatment or prophylaxis of arthritis. Also described is a method of treating a musculoskeletal disease, such as 5 arthritis, by administering the ulvan containing composition.

Abstract: Products for repairing cartilage lesions, method of preparation and uses thereof The present disclosure provides products and methods of preparation thereof, said products comprising a matrix of methacrylated gellan gum having a methacrylation degree between 1.5 and 6%, cartilage forming cells and a physiologically acceptable ionic solution containing cations, for application in tissue engineering and regenerative medicine, in particular cartilage lesions.

Abstract: The present application discloses cell-adhesive gellan gum spongy-like hydrogels that are able to entrap/encapsulate adherent cells, which spread within the material, maintaining their phenotype and remaining viable and proliferative. The methodology used to obtain these materials involves hydrogel preparation, freezing, freeze-drying and re-hydration with a saline solution with cells and with/without bioactive molecules. No pre and/or post functionalization of the spongy-like hydrogels with cell adhesive features, as used for other hydrogels, is used. The cell adhesive character of these materials, not observed in hydrogels, is in part explained by their physical properties, between sponges and hydrogels, dissimilar from the precursor hydrogels. The physical properties that are mainly different are the morphology, microstructure, water content, and mechanical performance.

Abstract: The present application discloses cell-adhesive gellan gum spongy-like hydrogels that are able to entrap/encapsulate adherent cells, which spread within the material, maintaining their phenotype and remaining viable and proliferative. The methodology used to obtain these materials involves hydrogel preparation, freezing, freeze-drying and re-hydration with a saline solution with cells and with/without bioactive molecules. No pre and/or post functionalization of the spongy-like hydrogels with cell adhesive features, as used for other hydrogels, is used. The cell adhesive character of these materials, not observed in hydrogels, is in part explained by their physical properties, between sponges and hydrogels, dissimilar from the precursor hydrogels. The physical properties that are mainly different are the morphology, microstructure, water content, and mechanical performance.

Abstract: Many reservoirs of interest include heavy oil. In such reservoirs, NMR measurements have difficulty distinguishing between heavy oil and water in the formation. An acoustic signal is used to modify the relaxation time distribution of water and heavy oil in opposite directions and thus increase the separability of the distributions.

Abstract: Many reservoirs of interest include heavy oil. In such reservoirs, NMR measurements have difficulty distinguishing between heavy oil and water in the formation. An acoustic signal is used to modify the relaxation time distribution of water and heavy oil in opposite directions and thus increase the separability of the distributions.

Abstract: A method for inducing proliferation of cytolytic T cells is described.

Abstract: A computer program product includes machine readable instructions stored on machine readable media, the instructions for correlating nuclear magnetic resonance (NMR) well logging data with other well logging data, the product including instructions for: receiving the NMR well logging data; receiving the other well logging data; determining a tendency of the NMR logging data to correlate with the other logging data and providing output including correlation information. A system is also provided.