Patents by Inventor Pedro Sanchez Cruz

Pedro Sanchez Cruz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photosensitized release of nitric oxide
    Patent number: 11807529
    Abstract: The invention proposes the photosensitized generation of nitric oxide (NO) from alanosine (3-(hydroxynitrosoamino)-D,L-alanine) by aluminum phthalocyanine tetrasulfonate (AlPcS4). While NO is obtained in nitrogen-saturated solutions, the invention proposes that both NO and peroxynitrite are produced in air-saturated solutions. Enhancement of NO production occurs in the presence of ubiquinone-0. The invention evidence that NO is produced by the photosensitized oxidation of alanosine. Both NO and peroxynitrite are detected during photoirradiation of AlPcS4 in the presence of 2-methyl-2-nitrosopropane (MNP) and hypoxanthine, but not in the absence of hypoxanthine, in air-saturated solutions, where HX is acting as sacrificial electron donor, thus promoting superoxide formation.
    Type: Grant
    Filed: May 25, 2020
    Date of Patent: November 7, 2023
    Assignee: University of Puerto Rico
    Inventors: Antonio E. Alegria, Pedro Sanchez Cruz
  • Photosensitized release of nitric oxide
    Patent number: 10662063
    Abstract: The invention proposes the photosensitized generation of nitric oxide (NO) from alanosine (3-(hydroxynitrosoamino)-D,L-alanine) by aluminum phthalocyanine tetrasulfonate (AlPcS4). While NO is obtained in nitrogen-saturated solutions, the invention proposes that both NO and peroxynitrite are produced in air-saturated solutions. Enhancement of NO production occurs in the presence of ubiquinone-0. The invention evidence that NO is produced by the photosensitized oxidation of alanosine. Both NO and peroxynitrite are detected during photoirradiation of AlPcS4 in the presence of 2-methyl-2-nitrosopropane (MNP) and hypoxanthine, but not in the absence of hypoxanthine, in air-saturated solutions, where HX is acting as sacrificial electron donor, thus promoting superoxide formation.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: May 26, 2020
    Assignee: University of Puerto Rico
    Inventors: Antonio E. Alegria, Pedro Sanchez Cruz