Abstract: The invention relates to a method for production of tyrosol, wherein a transgenic bacterial cell that heterologously expresses phenylpyruvate decarboxylase and that overexpresses phospho-2-dehydro-3-deoxyheptonate and prephenate dehydrogenase, and wherein pheAL and feaB are both inactivated or removed, is grown in a medium comprising a metabolic precursor of phosphoenolpyruvate (PEP) and erythrose 4-phosphate (E4P), particularly glucose, and optionally, phenylalanine as a supplement; and tyrosol is extracted from said medium. The invention also relates to a method for production of salidroside, wherein the transgenic cell additionally heterologously expresses uridine diphosphate dependent glycosyltransferase (UGT85A1, EC:2.4.1.

Abstract: The present invention relates to the use of 2,5-furanedicarboxylate-based MOFs, such as, MIL-160(AI) metal-organic framework, for separating C6 alkane isomers into linear, mono-branched and di-branched isomers. The present invention also relates to the use of 2,5-furanedicarboxylate-based MOFs, such as, MIL-160(AI) metal-organic framework, preferably in combination with Zeolite 5A for producing higher research octane number gasoline blends. Also within the scope of the invention is a system for separating C6 and C5 alkane isomer mixtures into linear, mono-branched and di-branched fractions.

Abstract: A system includes a memory a processor. The processor is in communication with the memory. The processor is configured to receive an application, where the application was modified into a second configuration from a first configuration. Next, the processor determines differences in the application between the second configuration and the first configuration. A database is accessed, which includes a set of known potential modifications to the application and a set of patterns. The functionality of the known potential modifications is dependent on at least one of the set of patterns. The differences are analyzed to determine which of the set of patterns to include in the application, where the differences includes at least one of the set of known potential modifications in the application. The processor is configured to modify the application with the at least one of the set of patterns.

Abstract: The present disclosure relates to 6-substituted quinoline-2-piperidine derivatives for use in the treatment and/or prevention of tuberculosis.

Abstract: A computer-implemented method of selecting a number format for use in configuring a hardware implementation of a bidirectional recurrent neural network (BRNN) for operation on a sequence of inputs. A received BRNN representation is implemented as a test neural network equivalent to the BRNN over a sequence of input tensors, each step of the test neural network being for operation on (a) an input tensor of the sequence, (b) a corresponding backward state tensor generated in respect of a subsequent input tensor of the sequence, and (c) a corresponding forward state tensor generated in respect of a preceding input tensor of the sequence. The test neural network includes a forward recurrent neural network (RNN) for operation on the forward state tensors over the input tensors of the sequence; and a backward RNN for operation on the backward state tensors over the input tensors of the sequence.

Abstract: A method of implementing in hardware a bidirectional recurrent neural network (BRNN) for operation on a sequence of inputs, each step of the BRNN being for operation on (a) an input of the sequence, (b) corresponding backward state generated in respect of a subsequent input of the sequence, and (c) corresponding forward state generated in respect of a preceding input of the sequence. A representation of the BRNN is transformed into a derivative neural network equivalent to the BRNN over the sequence of inputs. The derivative neural network includes a forward recurrent neural network (RNN) for operation on the forward state over the inputs of the sequence, and a backward recurrent neural network (RNN) for operation on the backward state over the inputs of the sequence. The derivative neural network is implemented in hardware so as to perform the BRNN on the sequence of inputs.

Abstract: The present disclosure also relates to compressed compositions comprising a therapeutically effective amount of macitentan, a sugar alcohol diluent and a surfactant. It also relates to the process of obtaining said compressed compositions, oral pharmaceutical compositions comprising them, and their use in the treatment of pulmonary arterial hypertension. The present disclosure also relates to solid oral pharmaceutical compositions comprising a therapeutically effective amount of macitentan that simultaneously display improved stability properties and adequate dissolution profiles represents an unmet need in the field of pharmaceutical macitentan formulation.

Abstract: A system includes a memory a processor. The processor is in communication with the memory. The processor is configured to receive an application, where the application was modified into a second configuration from a first configuration. Next, the processor determines differences in the application between the second configuration and the first configuration. A database is accessed, which includes a set of known potential modifications to the application and a set of patterns. The functionality of the known potential modifications is dependent on at least one of the set of patterns. The differences are analyzed to determine which of the set of patterns to include in the application, where the differences includes at least one of the set of known potential modifications in the application. The processor is configured to modify the application with the at least one of the set of patterns.

Abstract: The present invention is related to the process of obtaining CaO—MgO binders and construction products, with reuse of subproducts and/or residues and carbon dioxide, by compression molding (6). The binders are produced by crushing and grinding. The process of manufacturing the products consists of mixing binders and subproducts and/or residues with residual non-potable water (5), and curing this mixture with carbon dioxide (7), under constant humidity, temperature and pressure conditions. The process of hardening is carried out by recirculating carbon dioxide in a closed circuit, followed by drying of the products (12). The subproducts and/or residues contain calcium and magnesium and may be slag from the steel manufacturing industry or sand and mud resulting from the pulp, paper and cardboard production industry. The construction products may include other residues and materials containing silica and aluminum.

Abstract: The present invention relates to an improved process for the preparation of Pirlindole enantiomers, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to an improved process for the synthesis of piperazine ring, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of pyrazinocarbazoles such as the antidepressant Pirlindole. The process described is useful to prepare Pirlindole enantiomers, or a pharmaceutically accepted salt thereof.

Abstract: A backup power supply comprising a removably attachable battery that is configured to provide a backup power supply to an electrical appliance is disclosed herein. An electrical housing is configured to be mounted on the electrical appliance. A removably attachable battery is mounted on the electrical housing, which comprises a circuitry that includes a sensing device that is configured to detect primary power supply from a main power supply to the electrical appliance. A transfer switch is configured to select one of primary power supply provided by the main power supply or the backup power supply provided by removably attachable battery based on the sensing device deciding what is appropriate. A control circuitry is configured to control the transfer switch to engage the removably attachable battery in the circuitry when the sensing device fails to detect the primary power supply from the main power supply to the electrical appliance.

Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more scripts. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one memory. The operations may include: extracting, from an icon associated with a file, one or more features; assigning, based at least on the one or more features, the icon to one of a plurality of clusters; and generating, based at least on the cluster to which the icon is assigned, a classification for the file associated with the icon. Related methods and articles of manufacture, including computer program products, are also provided.

Abstract: The present invention relates to an improved process for the preparation of Pirlindole enantiomers, or a pharmaceutically acceptable salt thereof.

Abstract: A stretchable-diameter inserter, for hemodynamic studies and related operations, is characterized in that it comprises an inserter tube, a hemostatic valve designed for preventing blood from exiting the patient toward the operator, a side line including a faucet, adapted to be used for performing blood taking and infusion operations and two dilatators: a first dilatator having a smaller cross-section and a second dilatator having a larger cross-section.

Abstract: The present disclosure relates to an improved process for the synthesis of piperazine ring, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of pyrazinocarbazoles such as the antidepressant Pirlindole. The process described is useful to prepare Pirlindole enantiomers, or a pharmaceutically accepted salt thereof.

Abstract: A winding arrangement for an electric installation has an electric conductor and a plurality of cooling ducts. The electric conductor is coiled up forming several layers around an axis. Each cooling duct extends between a pair of adjacent layers of the coiled electric conductor in axial direction through the winding arrangement and in tangential direction not entirely around the axis. The cooling ducts of the plurality of cooling ducts are distributed among more than one pair of adjacent layers such that the winding arrangement is substantially cylindrical.

Abstract: A wheel unit includes a rotating wheel, a wheel axle, and a location sensor. The rotating wheel rotates with respect to the wheel axle. The location sensor is disposed in a fixed position with respect to the wheel axle. The location sensor determines coordinates for a location of the wheel unit.

Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more scripts. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one memory. The operations may include: extracting, from an icon associated with a file, one or more features; assigning, based at least on the one or more features, the icon to one of a plurality of clusters; and generating, based at least on the cluster to which the icon is assigned, a classification for the file associated with the icon. Related methods and articles of manufacture, including computer program products, are also provided.

Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more scripts. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one memory. The operations may include: extracting, from an icon associated with a file, one or more features; assigning, based at least on the one or more features, the icon to one of a plurality of clusters; and generating, based at least on the cluster to which the icon is assigned, a classification for the file associated with the icon. Related methods and articles of manufacture, including computer program products, are also provided.