Abstract: This document provides methods and materials related to treating subjects having specific genetic variations associated with neurological disorders such as Parkinson's disease.

Abstract: This document provides methods and materials related to treating subjects having specific genetic variations associated with neurological disorders such as Parkinson's disease.

Abstract: A universal tag assay is disclosed wherein at least one invasive cleavage reaction (ICR) is used to generate tagged molecules having identifier tags corresponding to target nucleotide sequences, and further wherein hybridization of any tagged molecule with a complementary detection probe on a universal detector indicates the presence of the corresponding target in the sample being assayed. Preferred embodiments include the use of ICR to generate molecules suitable for use in the universal tag assay to detect variant nucleotide sequences including single nucleotide polymorphisms (SNPs), allelic variants, and splice variants. Hybridization of tagged molecules to detection probes is preferably detected by electrochemical readout, in particular the use of ruthenium amperometry to detect hybridization of identifier tags to detection probes immobilized on a universal detector, preferably a universal chip having gold or carbon electrodes.

Abstract: The invention provides methods for diagnosing B-cell lymphoma in an animal. In particular, the invention provides methods for distinguishing an animal having diffuse large B-cell lymphoma (DLBCL) with an activated B-cell (ABC) phenotype from an animal having DLBCL with a non-activated germinal-center (GC) phenotype. The invention also provides methods for identifying compounds for treating B-cell lymphoma. The invention further provides reagents and methods for determining the amount of miR-155 in sample isolated from an animal. In this regard, the invention provides a set of oligonucleotides for determining the amount of miR-155 in sample isolated from an animal.