Abstract: The present disclosure relates to a method for determining initiation positions of fretting fatigue cracks. The processed inner circular hole test workpiece is placed on a stage of an optical microscope, wherein the inner hole surface to be measured is perpendicular to the scanning beam direction of the microscope; measurement is performed along the real contact orientation between the inner hole surface of the inner circular hole test workpiece and the pin shaft. From the measured surface morphology and profile image, rectangular target areas with a coverage rate of 75%˜90%, and the amplitude distribution function, surface skewness and surface kurtosis values of the respective surface profiles are extracted from the target areas. By comparing the positive/negative of and the magnitude of the skewness and kurtosis values measured in the target areas, the side where the initiation position of fretting fatigue cracks is located can be determined.

Abstract: A method, system and external instrument are provided. The method initiates a communication link between an external instrument (EI) and an implantable medical device (IMD), established a first connection interval for conveying data packets between the EI and IMD and monitors a connection criteria that includes at least one of a data throughput requirement. A battery indicator or link condition of the communications link is between the IMD and EI. The method further changes from the first connection interval to a second connection interval based on the connection criteria.

Abstract: Provided are an order delivery method, an electronic device, a delivery robot and a transfer system. The delivery robot includes a moving and storage system, an interaction apparatus and a control apparatus. The transfer system includes at least one storage bin, a transfer mechanism, an interaction apparatus and a control apparatus. The electronic device is configured to perform the order delivery method, including: obtaining an order set and status information of a delivery robot, and determining a delivery mode of the delivery robot for an in-delivery order according to the order set and the status information of the delivery robot. In these examples, the transfer or delivery of an order can be achieved by interaction of the delivery robot, the transfer system and the electronic device, thereby improving the efficiency of a delivery process.

Abstract: A device comprising one or more heat transfer laminates each including an electrode, a first dielectric layer on a first side of the electrode, and a second dielectric layer on a second side of the electrode; a plurality of flexible electrocaloric elements, each of the flexible electrocaloric elements including an electrocaloric material layer, a flexible electrode layer on the electrocaloric layer, one or more fixed portions each attached to one of heat transfer laminates, and a movable portion that is movable with respect to the one of the heat transfer laminates.

Abstract: A method is provided for forming an add-on component for an aerofoil which enable the structure of the aerofoil to be tuned in order to reduce the amplitude of sound produced at frequency fpeak when air flows in a flow direction from the leading edge over the trailing edge of an aerofoil. The method applies both to add-on components having a slitted formation and a Double-Rooted Trailing Edge Serration (abbreviated to “DRooTES”).

Abstract: The disclosure relates to a pixel circuit and a testing method of the pixel circuit. The pixel circuit comprises a light emitting element, a storage capacitor Cst, a drive sub-circuit, a reset sub-circuit, a write sub-circuit, a light emission control sub-circuit and a testing element, wherein a control terminal of the testing element is connected to s reset control signal line, a first terminal of the testing element is connected to a reset signal line, a second terminal of the testing element is connected to the drive sub-circuit, and the testing element is configured to test elements included in the pixel circuit.

Abstract: Disclosed are an instant messaging sound quality optimization method, an apparatus and a device. The method includes: obtaining first human voice data, the first human voice data being voice data of a user of a first client terminal; using a loudspeaker to play the first human voice data, local background music of a second client terminal to obtain first audio data; using a microphone to collect the first audio data and second human voice data to obtain second audio data, the second human voice data being voice data of a user of a second client terminal; filtering the first human voice data in the second audio data to obtain filtered audio data; when the background music played by the first client terminal is the second client terminal, sending the filtered audio data to the first client terminal to enable the first client terminal to play the filtered audio data.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding fragments of antibodies described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof.

Abstract: An Electrocardiography (ECG) noise-filtering device is provided in the invention. The ECG device includes a filter and a calculation circuit. The filter receives a first ECG signal and performs a Savitzky-Golay algorithm to generate a second ECG signal. The calculation circuit is coupled to the filter to receive the second ECG signal and processes the second ECG signal according to a Stationary Wavelet Transform (SWT) algorithm to generate a noise signal, and subtracts the noise signal from the second ECG signal to filter the noise signal in the first ECG signal.

Abstract: Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a molar ratio of the amide-type anesthetic to the at least one lipid of the lipid-based complex is at least 0.5:1. The total amount of the amide-type anesthetic is at least 1.5 to 5 times of a standard therapeutic dose for treating postsurgical pain with the amide-type anesthetic to achieve an improved pain control with desired prolonged analgesic effect.

Abstract: Disclosed are antagonists of PC3-secreted microprotein (PSMP) and use of the antagonists for treatment of liver, lung, or kidney fibrosis, including various diseases or disorders associated with liver, lung, or kidney fibrosis such as, e.g., non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), drug-induced lung injury, acute kidney injury (AKI), chronic kidney disease (CKD), lupus nephritis, IgA nephropathy, and membranous glomerulonephritis. Also disclosed are PSMP antagonists and their use for treatment of graft-versus-host disease (GVHD) and systemic lupus erythematosus (SLE). Suitable PSMP antagonists for use in disease treatment include PSMP-binding proteins such as, for example, neutralizing anti-PSMP antibodies.

Abstract: The present disclosure provides a semiconductor device. The semiconductor device includes a semiconductor component, a re-routing layer, a bonding dielectric and an insulating layer. The re-routing layer is disposed over the semiconductor component and electrically coupled to the semiconductor component. The bonding dielectric is disposed over the semiconductor component to surround a top portion of the re-routing layer. The insulating layer is disposed between the semiconductor component and the bonding dielectric to surround a bottom portion of the re-routing layer.

Abstract: Disclosed is a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally constrained bicyclic structure through the formation of a pair of disulfide bonds. The resulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell-permeability. Once inside the cell, the disulfide bonds are reduced to produce a linear, biologically active peptide. This strategy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the NEMO-IKK interaction.

Abstract: The present disclosure provides a semiconductor die structure with air gaps for reducing capacitive coupling between conductive features and a method for preparing the semiconductor die structure. The semiconductor die structure includes a substrate; a first supporting backbone disposed on the substrate; a second supporting backbone disposed on the substrate; a first conductor block disposed on the first supporting backbone; a second conductor block disposed on the second supporting backbone; a third conductor block disposed above the substrate and connected to the first conductor block and the second conductor block; and an air gap structure disposed between the first conductor block, the second conductor block, and the third conductor block, wherein the air gap structure comprises an air gap and a liner layer enclosing the air gap.

Abstract: A lighting assembly includes a light stand, a lighting unit, and a modular rod assembly connecting the lighting unit to the light stand. The modular rod assembly includes a connection rod, a first extension rod connected to the connection rod, and a tubular fastener. The connection rod has a first coupling end. The first extension rod has a second coupling end. The tubular fastener is movably disposed around the first extension rod and is operable to move toward and sleeve around the first and second coupling ends such that the tubular fastener is engaged with the first coupling end and that the second coupling end is clamped between the first coupling end and the tubular fastener.

Abstract: A stirring device includes a stirring unit, a gas supplying unit, and a feeding unit. The stirring unit includes a drive mechanism and a shaft member. The shaft member includes a hollow rotary shaft coupled to be driven by the drive mechanism to rotate, and a stirring head coupled to rotate with the hollow rotary shaft. The gas supplying unit includes a gas supply, and a piping member fluidly communicating with the gas supply and the shaft member. The feeding unit includes a storage tank and a feeding tube fluidly communicating with the storage tank and the shaft member.

Abstract: The present disclosure, in some embodiments, relates to a method of forming an integrated chip. The method may be performed by forming a gate structure over a substrate and between a source region and a drain region. A composite etch stop structure is formed over the gate structure and a first inter-level dielectric (ILD) layer is formed over the composite etch stop structure. The composite etch stop structure has a plurality of stacked dielectric materials. The first ILD layer is etched to concurrently define contact openings extending to the substrate and a field plate opening extending to the composite etch stop structure. The contact openings and the field plate opening are concurrently filled with one or more conductive materials.