Abstract: The present application relates to a multi-immunogen chimeric or mixed antigen for a poxvirus, particularly monkeypox virus, related products, and preparation method and use thereof. The chimeric or mixed antigen of the present application comprises three immunogens: (1) a monkeypox virus A35R protein or an antigenic fragment thereof (or a peptide fragment derived therefrom), (2) a monkeypox virus M1R protein or an antigenic fragment thereof (or a peptide fragment derived therefrom), and (3) a monkeypox virus B6R protein or an antigenic fragment thereof (or a peptide fragment derived therefrom), and can elicit an immune response against two types of infectious virus particles, namely intracellular mature virus particles (IMV) and extracellular envelope virus particles (EEV), thereby efficiently inducing specific immunoprotective effects against the monkeypox virus.

Abstract: Provided are a polynucleotide encoding a chimeric or mixed antigen of poxvirus multiple immunogens, a related nucleic acid product thereof, and the use thereof in the preparation of a vaccine for preventing and/or treating poxvirus (in particular monkeypox virus) infection. The chimeric or mixed antigen of the poxvirus multiple immunogens encoded by the polynucleotide comprises two immunogens: a monkeypox virus A35R protein or an antigenic fragment thereof (or an appropriate variant thereof) and a monkeypox virus MIR protein or an antigenic fragment thereof (or an appropriate variant thereof).

Abstract: The present application provides a lyophilized bead pre-embedding structure, a digital microfluidic chip, and a pre-embedding and liquid injection method. The present application realizes normal-temperature transportation of the digital microfluidic chip, saves the transportation cost, and improves the stability and reliability of chip reagent pre-embedding.

Abstract: A system device and method for quantitatively injecting a tested sample into a chip, and a use. The system device is used for injecting a quantitative tested sample into a gap chamber of a chip; the system device comprises a sample quantification assembly and a liquid injection chamber; the sample quantification assembly comprises a body; a quantitative chamber is provided in the body; the liquid injection chamber comprises an open housing; a partition plate is provided in the housing; the partition plate divides the housing into a first chamber and a second chamber; the tested sample is injected into the first chamber; the sample quantification assembly is placed in the liquid injection chamber and is continuously pressed down; the body extends into the first chamber for quantitative injection.

Abstract: A microfluidic chip, wherein the microfluidic chip comprises a microfluidic chip substrate, a conductive cover and a liquid injection housing, wherein the liquid injection housing is provided with at least one liquid injection conduit and an oil intake conduit; wherein the liquid injection housing comprises an oil injection cavity, a sample dosing cavity, and at least one liquid injection cavity; a liquid injection column connected to a corresponding one of the at least one liquid injection conduit is arranged respectively in each of the at least one liquid injection cavity, and each of the at least one liquid injection conduit forms a liquid injection channel; an oil injection column is arranged in the oil injection cavity and is connected to the oil intake conduit; and surfaces of the oil injection cavity and the at least one liquid injection cavity are each correspondingly provided with a spike component.

Abstract: The present invention relates to the display technology field, and provides a backplate, a plastic-iron integrated structure, a backlight unit, and a display device. The backplate is provided with a first through hole, and the first through hole has an inner wall and an outer wall which form a projection structure on the backplate. When the backplate is bonded with a plastic frame to form the plastic-iron integrated structure, the plastic frame not only contacts the inner wall of the first through hole, but also contacts the surface of the projection structure, thus increasing the contact area between the plastic frame and the backplate, and increasing the bonding force between the plastic frame and the backplate. Even when the plastic frame shrinks in case of fluctuations in temperature and/or humidity, the plastic frame is not easily separated from the backplate, and the stability of the formed plastic-iron integrated structure is improved.

Abstract: The present invention relates to the display technology field, and provides a backplate, a plastic-iron integrated structure, a backlight unit, and a display device. The backplate is provided with a first through hole, and the first through hole has an inner wall and an outer wall which form a projection structure on the backplate. When the backplate is bonded with a plastic frame to form the plastic-iron integrated structure, the plastic frame not only contacts the inner wall of the first through hole, but also contacts the surface of the projection structure, thus increasing the contact area between the plastic frame and the backplate, and increasing the bonding force between the plastic frame and the backplate. Even when the plastic frame shrinks in case of fluctuations in temperature and/or humidity, the plastic frame is not easily separated from the backplate, and the stability of the formed plastic-iron integrated structure is improved.