Abstract: The present invention relates to a pharmaceutical composition comprising a weak acid drug, with the use of a bicarbonate salt to achieve a high incorporation of the drug into the liposome and a better therapeutic efficacy. Also disclosed is a method for treating a respiratory disease using the pharmaceutical composition disclosed herein.

Abstract: A method for predicting an attacked path on enterprise networks includes: obtaining a plurality of accounts, a plurality of machines and network resource data, where the plurality of machines include at least one attacked target; calculating, according to the network resource data, a plurality of evaluated values of executing access on other machines of each account logging in at least one machine; and presenting an attacked path where a machine at least one account logs in accesses the attacked target directly, or indirectly by connecting to other machines, and the machine the at least one account logs in points to the attacked target directly, or indirectly by connecting to other machines.

Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.

Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.

Abstract: The present invention provides an event visualization device configured to generate one or more directed acyclic graphs (DAGs) that can be used as a basis for diagnosing whether a target network system has been hacked according to a plurality of activities records. The plurality of activities records pertain to an event cluster associated with a suspicious event category. The event visualization device performs a graph generating operation on the plurality of activities records in a recursive manner to generate a hierarchical directed acyclic graph (HDAG). The graph generating operation includes: interpreting an activities record into a target DAG, and performing a hierarchical partial order alignment (HPOA) operation on the target DAG and a reference DAG to obtain a merging condition of each node; and merging the target DAG and the reference DAG into the HDAG according to the merging condition.

Abstract: The present invention provides a log classification system configured to perform a hierarchical similarity analysis operation according to a plurality of activities records to generate a discrete space metric tree, and perform a clustering operation on the discrete space metric tree to generate one or more event clusters associated with one or more suspicious event categories. The log classification system includes an output device configured to output the one or more event clusters to an information security incident diagnosis system, and allow the information security incident diagnosis system to calculate similar feature information and differential feature information of a plurality of activities records in the one or more event clusters as auxiliary information for diagnosing whether there are intrusions or abnormalities in a target network system.

Abstract: The present invention provides an information security incident diagnosis system for assisting in detecting whether a target network system has been hacked. First, a plurality of activities records of one or more computing devices in a target network system are collected. Then, a discrete space metric tree is generated according to the plurality of activities records, and a clustering operation is performed on the discrete space metric tree to generate one or more event clusters associated with one or more suspicious event categories. Each event cluster may form a guide tree corresponding to the event cluster through single linkage clustering analysis to indicate a merging order from high to low similarity. The merging order is used for recursively performing a graph generating operation to convert a plurality of activities records corresponding to the one or more event clusters into a hierarchical directed acyclic graph (HDAG).

Abstract: A cyber security protection system includes a plurality of threat information updating devices; and a proactive suspicious domain alert system, which including: a domain information monitoring device; a domain information storage device; and a security threat analysis device, arranged to operably communicate data with the plurality of threat information updating devices through a network. If the domain information monitoring device detects that a domain mapping of a suspect domain is changed and the new domain mapping of the suspect domain points to a predetermined local address, the domain information monitoring device would further monitor a domain mapping variation frequency of the suspect domain. If the domain mapping variation frequency of the suspect domain exceeds a predetermined value, the security threat analysis device adds the suspect domain into an alert list to render the plurality of threat information updating devices to block their member devices from accessing the suspect domain.

Abstract: A cyber security protection system includes a plurality of threat information updating devices; and a proactive suspicious domain alert system, which including: a domain information monitoring device, arranged to operably inspect domain ages of suspect domains; a domain information storage device; and a security threat analysis device, arranged to operably communicate data with the plurality of threat information updating devices through a network. Before the domain age of a suspect domain reaches a first threshold value, if the plurality of threat information updating devices discovers that an member device within a plurality of client network systems is trying to access the suspect domain, the security threat analysis device adds the suspect domain into an alert list to render the plurality of threat information updating devices to block member devices within the plurality of client network systems from accessing the suspect domain.

Abstract: A suspicious event analysis device includes: a display device; a communication circuit, arranged to operably receive multiple suspicious activities records related to multiple computing devices in a target network and corresponding multiple time stamps and multiple attribute tags through internet; a storage circuit, arranged to operably store a suspicious event sequence diagram generating program; and a control circuit, arranged to operably execute the suspicious event sequence diagram generating program to conduct a suspicious event sequence diagram generating operation, so as to identify multiple suspicious events related to the target network as well as multiple time records corresponding to the multiple suspicious events, and to generate and display a suspicious event sequence diagram corresponding to the multiple suspicious events according to the multiple suspicious events and the multiple time records.

Abstract: A cyber security protection system includes a plurality of threat information updating devices; and a proactive suspicious domain alert system, which including: a domain information monitoring device; a domain information storage device; and a security threat analysis device, arranged to operably communicate data with the plurality of threat information updating devices through a network. If the domain information monitoring device detects that a domain mapping of a suspect domain is changed and the new domain mapping of the suspect domain points to a predetermined local address, the domain information monitoring device would further monitor a domain mapping variation frequency of the suspect domain. If the domain mapping variation frequency of the suspect domain exceeds a predetermined value, the security threat analysis device adds the suspect domain into an alert list to render the plurality of threat information updating devices to block their member devices from accessing the suspect domain.

Abstract: A cyber security protection system includes a plurality of threat information updating devices; and a proactive suspicious domain alert system, which including: a domain information monitoring device, arranged to operably inspect domain ages of suspect domains; a domain information storage device; and a security threat analysis device, arranged to operably communicate data with the plurality of threat information updating devices through a network. Before the domain age of a suspect domain reaches a first threshold value, if the plurality of threat information updating devices discovers that an member device within a plurality of client network systems is trying to access the suspect domain, the security threat analysis device adds the suspect domain into an alert list to render the plurality of threat information updating devices to block member devices within the plurality of client network systems from accessing the suspect domain.

Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.

Abstract: Provided herein are pharmaceutical compositions containing (a) at least one liposome includes at least one vesicle-forming phospholipid; and (b) treprostinil encapsulated within the liposome. The ratio of treprostinil to phospholipid is equal to or higher than 0.035 and provides a controlled release of treprostinil. Also provided is the use of the pharmaceutical compositions to treat respiratory diseases.

Abstract: The present invention relates to pharmaceutical compositions comprising at least one liposome, at least one polyvalent counterion donor or a pharmaceutically acceptable salt thereof, at least one monovalent counterion donor or a pharmaceutically acceptable salt thereof, and an amphipathic therapeutic agent or a derivative or pharmaceutically acceptable salt thereof. The present invention also relates to methods of inhibiting cancer cell growth while reducing toxicity, comprising administering the pharmaceutical composition described herein.

Abstract: Provide is a method of using a topoisomerase I inhibitor in treatment of cancer to reduce bone marrow suppression. The method includes administering to a subject in need thereof an effective amount of a pharmaceutical composition. The composition has at least one hydrophobic topoisomerase I inhibitor or a pharmaceutically acceptable salt thereof, and at least one polyethylene glycol (PEG) conjugated phospholipid, wherein the molar ratio of said PEG conjugated phospholipid to said hydrophobic topoisomerase I inhibitor or said pharmaceutically acceptable salt of said hydrophobic topoisomerase I inhibitor is about 0.45:1 to about 1.05:1.

Abstract: The present invention relates to a pharmaceutical composition containing liposomes, said liposome comprise an external lipid bilayer; and an internal aqueous medium including a weak acid drug with a half-life of less than 2 hours. Also provided is the use of the pharmaceutical composition disclosed herein to treat pulmonary hypertension with reduced dosing frequency.

Abstract: Provided herein are pharmaceutical compositions containing at least one liposome, said liposome comprise an external lipid bilayer including at least one vesicle-forming phospholipid and less than 15 mole % of sterol; and an internal aqueous medium including a weak acid drug and weak acid salt. The pharmaceutical compositions reduce the burst release of the weak acid drug. Also provided is the use of the pharmaceutical composition disclosed herein to treat respiratory diseases and reduce the side effect of the weak acid drug.