Abstract: A method and apparatus for surface plasmon resonance imaging are provided for imaging the surface plasmon resonance signals caused by the interaction of biomolecules. In particular, the method and apparatus can image the slightly spectral change in a surface plasmon resonance mode by comparing the light intensities of two bands in the frequency domain of the surface plasmon.

Abstract: A surface plasmon resonance sensor is provided, which comprises: a substrate; an adaptation layer disposed on the substrate and comprising a dielectric material; and a metal layer disposed on the adaptation layer, wherein the metal layer has a grating structure comprising plural metal lines. Furthermore, a surface plasmon resonance sensing instrument comprising the same and a method for detecting an analyte using the same are also provided.

Abstract: The present disclosure provide a detection device of microfluidic polymerase chain reaction (PCR) and a detection system including the same. This all-in-one device and system may be used to detect at least one biological detection chip, so that can amplify gene fragments at the front-end and detect them at the back-end immediately, decreasing the time required for the analysis, enabling real-time, low-cost, and rapid detection of various viruses, such as EBV and COVID-19, without compromising accuracy or sensitivity.

Abstract: A detection method and a detection system for detecting objects of interest attached to a surface of a plurality of reporters, wherein the plurality of reporters are flowing in a microfluidic chip and illuminated by a light source. The detection method has following steps: obtaining a plurality of local surface plasmon resonance (LSPR) spectral images of each the plurality of the reporters individually, wherein each of the LSPR spectral images has a brightness of a long wavelength band (BA) and a brightness of a short wavelength band (BB); calculating a spectral image brightness contrast ? for each of the LSPR spectral images, wherein ? = B A - B B B A + B B ; and, defining a positive threshold for |?|?0.1.

Abstract: A method and apparatus for surface plasmon resonance imaging are provided for imaging the surface plasmon resonance signals caused by the interaction of biomolecules. In particular, the method and apparatus can image the slightly spectral change in a surface plasmon resonance mode by comparing the light intensities of two bands in the frequency domain of the surface plasmon.

Abstract: The present invention pertains to detection of a tumor in a urinary organ using microRNA(s). MiR-200c-5p, miR-214-3p, miR-21-5p, miR-21-3p, miR-210-3p and/or miR-200b-3p can be used as biomarkers of tumors in a urinary organ to detect a tumor in or predict a prognosis of a tumor in a urinary organ.

Abstract: The present invention provides a label-free sensing chip for identifying a chemical substance, comprising: (a) a transparent substrate comprising a base and first periodic ridges; and (b) a metal layer covering said transparent substrate, comprising second periodic ridges and third periodic ridges, in which said second periodic ridges has a height equal to or greater than the height of the first periodic ridges, and each ridge of the second periodic ridges fits into the space between each ridge of the first periodic ridges, and said third periodic ridges correspondingly located on said first periodic ridges. The present invention also provides a method for identifying a chemical substance by using the foresaid label-free sensing chip.

Abstract: A curved diffraction grating includes a substrate and a metal layer. The substrate is a two-dimensional curved plate structure and has a first surface, a second surface and a plurality of microstructures. The first surface is disposed opposite to the second surface, and the microstructures are disposed on the second surface. Each of the microstructures is a saw-tooth structure and has a clear blazed angle. The metal layer is disposed on the microstructures and has a plurality of diffraction structures corresponding to the microstructures. A spectrometer containing the curved diffraction grating and a manufacturing method of the curved diffraction grating are also disclosed.

Abstract: The present invention provides a label-free sensing chip for identifying a chemical substance, comprising: (a) a transparent substrate comprising a base and first periodic ridges; and (b) a metal layer covering said transparent substrate, comprising second periodic ridges and third periodic ridges, in which said second periodic ridges has a height equal to or greater than the height of the first periodic ridges, and each ridge of the second periodic ridges fits into the space between each ridge of the first periodic ridges, and said third periodic ridges correspondingly located on said first periodic ridges. The present invention also provides a method for identifying a chemical substance by using the foresaid label-free sensing chip.

Abstract: An LCD including a backlight module and an LCD panel is provided. The LCD panel includes a color light guide panel, suitable for differentiating an incident light into multiple color lights. The color light guide panel includes a substrate and a color light output structure. The substrate has multiple pixel regions, and the color light output structure is disposed in each of the pixel regions. The color light output structure includes first˜fourth nano-patterns. The incident light is scattered by the first nano-pattern for producing a first color light, scattered by the second nano-pattern for producing a second color light, scattered by the third nano-pattern for producing a third color light, and scattered by the fourth nano-pattern for producing a fourth color light. The color light guide panel can output uniform and high luminous first˜fourth color light, and the LCD can display high quality image.

Abstract: An LCD including a backlight module and an LCD panel is provided. The LCD panel includes a color light guide panel, suitable for differentiating an incident light into multiple color lights. The color light guide panel includes a substrate and a color light output structure. The substrate has multiple pixel regions, and the color light output structure is disposed in each of the pixel regions. The color light output structure includes first˜fourth nano-patterns. The incident light is scattered by the first nano-pattern for producing a first color light, scattered by the second nano-pattern for producing a second color light, scattered by the third nano-pattern for producing a third color light, and scattered by the fourth nano-pattern for producing a fourth color light. The color light guide panel can output uniform and high luminous first˜fourth color light, and the LCD can display high quality image.

Abstract: A color light guide panel, suitable for differentiating an incident light into multiple color lights is provided. The color light guide panel includes a substrate and a color light output structure. The substrate has multiple pixel regions, and the color light output structure is disposed in each of the pixel regions. The color light output structure includes a first nano-pattern, a second nano-pattern and a third nano-pattern. The incident light is scattered by the first nano-pattern for producing a first color light, scattered by the second nano-pattern for producing a second color light, and scattered by the third nano-pattern for producing a third color light. The color light guide panel can output uniform and high luminous first, second and third color light. Moreover, a liquid crystal display device having the above color light output structure is also provided.

Abstract: A color light guide panel, suitable for differentiating an incident light into multiple color lights is provided. The color light guide panel includes a substrate and a color light output structure. The substrate has multiple pixel regions, and the color light output structure is disposed in each of the pixel regions. The color light output structure includes a first nano-pattern, a second nano-pattern and a third nano-pattern. The incident light is scattered by the first nano-pattern for producing a first color light, scattered by the second nano-pattern for producing a second color light, and scattered by the third nano-pattern for producing a third color light. The color light guide panel can output uniform and high luminous first, second and third color light. Moreover, a liquid crystal display device having the above color light output structure is also provided.

Abstract: A system and method for producing label-free micro-array biochip based on the surface plasmon resonance in metallic nano-slit arrays, wherein the micro-array biochip of the does not utilize fluorescent labeling. Without the fluorescence labeling, the label-free micro-array substantially reduces the sample cost and can detect bio-molecular interactions in their native forms.

Abstract: The present invention is a method for providing light onto a thin light transparent substrate comprising the steps of passing noncoherent light through a fiber optic line light guide to produce line light; and impinging the line light onto the edge of the substrate to produce an evanescent planar wave on the surface of the substrate. This method is specifically useful in reading fluorescent signals from microarrays placed on a light transparent substrate.

Abstract: Techniques for chemically etching a fiber tip to form a smooth fiber probe. One implementation applies a coating layer around a bare fiber to expose only an end facet of the bare fiber and then the exposed end facet is immersed into an etching liquid to be away from a meniscus interface between the etching liquid and the fiber to etch the fiber from the end facet.

Abstract: Techniques for chemically etching a fiber tip to form a smooth fiber probe. One implementation applies a coating layer around a bare fiber to expose only an end facet of the bare fiber and then the exposed end facet is immersed into an etching liquid to be away from a meniscus interface between the etching liquid and the fiber to etch the fiber from the end facet.

Abstract: We disclose a new optical TE-TM mode splitter on lithium niobate. The splitter is fabricated by using an asymmetric Y-junction structure which is composed of a straight waveguide, and two branch waveguides. The straight waveguide is the input one that can guide randomly-polarized light (i.e. both TE and TM modes). The two branch waveguides are the output ones, and one of them can guide only the TE mode, the other can guide only the TM mode. Because the output waveguides can individually guide the TE and TM modes, the input modes are then split by the branch waveguides. The input waveguide is fabricated by diffusing titanium into lithium niobate. The two output waveguides are made by nickel indiffusion and magnesium-oxide induced lithium outdiffusion or proton exchanged techniques.