Patents by Inventor Pei Lian MA

Pei Lian MA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REVERSIBLE COATING OF CHITOSAN-NUCLEIC ACID NANOPARTICLES AND METHODS OF THEIR USE
    Publication number: 20220395584
    Abstract: Chitosan-nucleic acid polyplex compositions containing a reversibly bound polymer coat comprising linear block copolymers with a polyanionic anchor region and at least one polyethylene glycol tail region are described herein. In some cases, the compositions exhibit improved stability and/or mucosal diffusion as compared to uncoated particles. In some cases, the reversibly bound polymer coat does not interfere with, or enhances, transfection of target cells or tissues as compared to uncoated particles.
    Type: Application
    Filed: March 13, 2020
    Publication date: December 15, 2022
    Inventors: Rajesh Krishnan Gopalakrishna PANICKER, Daniel VEILLEUX, Pei Lian MA, Natalie Chin Mun TAM, Carlos FLEET, Anthony CHEUNG
  • CHITOSAN POLYPLEX-BASED LOCALIZED EXPRESSION OF IL-12 ALONE OR IN COMBINATION WITH TYPE-I IFN INDUCERS FOR TREATMENT OF MUCOSAL CANCERS
    Publication number: 20220370637
    Abstract: The present disclosure relates to methods and compositions comprising derivatized-chitosan polyplexes reversibly coated with a polyanion-containing block co-polymer for the localized expression of IL-12 in mucosal tissues, preferably in combination with an IFN-1 activator/inducer, for use in cancer immunotherapy.
    Type: Application
    Filed: March 13, 2020
    Publication date: November 24, 2022
    Inventors: Rajesh Krishnan Gopalakrishna PANICKER, Daniel VEILLEUX, Pei Lian MA, Natalie Chin Mun TAM, Carlos FLEET, Anthony CHEUNG, Shauna DAUPHINEE, Ximin CHEN, Jose LORA