Abstract: Methods for detecting a deficient DNA repair mechanism and/or evaluating microsatellite instability in a sample from a subject are described. The disclosed methods comprise analyzing nucleic acid sequence data for a plurality of microsatellite loci to calculate a microsatellite instability (MSI) score for the sample from a ratio of the number of microsatellite loci that exhibit variant alleles to the total number of microsatellite loci that meet, e.g., a minimum sequencing coverage requirement. The MSI score is compared a first threshold and, m some cases, to a second threshold to assign a status of high microsatellite instability?(MSI-H), microsatellite stable (MSS), or equivocal microsatellite instability (MSI-E) for the sample.

Abstract: The fire sprinkler head comprises a water supply pipe including a pipe and a joint coupling to the pipe and forming a connecting end opposite to the pipe; a mount including a cavity formed on the top thereof and adapted to receive the connecting end, a hole defined on the bottom of the cavity, an edge surrounding the hole with a first end and a second end, a recess defined between the first and the second end of the edge and a housing; a nozzle device defining a first end with exterior threads adapted to engage the edge of the mount to the connecting end of the water supply pipe, a second end having an engaging portion and a nozzle, and a hollow; a cover device including a cover, an opening formed in the center of the cover and a plurality of lugs around the opening.

Abstract: The fire sprinkler head comprises a water supply pipe including a pipe and a joint coupling to the pipe and forming a connecting end opposite to the pipe; a mount including a cavity formed on the top thereof and adapted to receive the connecting end, a hole defined on the bottom of the cavity, an edge surrounding the hole with a first end and a second end, a recess defined between the first and the second end of the edge and a housing; a nozzle device defining a first end with exterior threads adapted to engage the edge of the mount to the connecting end of the water supply pipe, a second end having an engaging portion and a nozzle, and a hollow; a cover device including a cover, an opening formed in the center of the cover and a plurality of lugs around the opening.

Abstract: A system and method for translating data from a source language to a target language is provided wherein machine generated target translation of a source sentence is compared to a database of human generated target sentences. If a matching human generated target sentence is found, the human generated target sentence may be used instead of the machine generated sentence, since the human generated target sentence is more likely to be a well-formed sentence than the machine generated sentence. The system and method does not rely on a translation memory containing pairs of sentences in both source and target languages, and minimizes the reliance on a human translator to correct a translation generated by machine translation.