Patents by Inventor Pei-Pei Kung

Pei-Pei Kung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060046287
    Abstract: The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 2, 2006
    Inventors: Pei-Pei Kung, Carlos Martinez, Junhua Tao
  • Publication number: 20060046991
    Abstract: Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 2, 2006
    Inventors: Jingrong Cui, Lee Funk, Lei Jia, Pei-Pei Kung, Jerry Meng, Mitchell Nambu, Mason Pairish, Hong Shen, Michelle Tran-Dube
  • Publication number: 20050009840
    Abstract: Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
    Type: Application
    Filed: February 26, 2004
    Publication date: January 13, 2005
    Inventors: Jingrong Cui, Dilip Bhumralkar, Iriny Botrous, Ji Chu, Lee Funk, Cathleen Hanau, G. Harris, Lei Jia, Joanne Johnson, Stephen Kolodziej, Pei-Pei Kung, Xiaoyuan Li, Jason Lin, Jerry Meng, Mitchell Nambu, Christopher Nelson, Mason Pairish, Hong Shen, Michelle Tran-Dube, Allison Walter, Fang-Jie Zhang, Jennifer Zhang
  • Publication number: 20040043959
    Abstract: The present invention is directed to combination therapies for treating cell proliferative disorders associated with methylthioadenosine phosphorylase (MTAP) deficient cells in a mammal. The combination therapies selectively kill MTAP-deficient cells by administering an inhibitor of de novo inosinate synthesis and administering an anti-toxicity agent, wherein the inhibitors of de novo inosinate synthesis are inhibitors of glycinamide ribonucleotide formyltransferase (“GARFT”) and/or aminoinidazolecarboximide ribonucleotide formyltransferase (“AICARFT”), and the anti-toxicity agent is an MTAP substrate (e.g. methylthioadenosine or “MTA”), a precursor of MTA, an analog of an MTA precursor or a prodrug of an MTAP substrate.
    Type: Application
    Filed: February 14, 2003
    Publication date: March 4, 2004
    Inventors: Laura A. Bloom, Theodore J. Boritzki, Richard Ogden, Donald Skalitzky, Pei-Pei Kung, Luke Zehnder, Leslie Kuhn, Jerry Jialun Meng
  • Patent number: 6660466
    Abstract: Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: December 9, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Pei-Pei Kung, Andrew Mamoru Kawasaki
  • Patent number: 6207826
    Abstract: Novel macrocyclic compounds are constructed to include a ring or ring system having two bridgehead atoms with a bridge extending between the bridgehead atoms. Located in at least the bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring or ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: March 27, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Charles J. Guinosso, Pei-Pei Kung, Allister S. Fraser
  • Patent number: 6156758
    Abstract: Provided are compounds of formula (I) ##STR1## wherein X, Y and Z are independently CH or N; n is 0 or 1; R.sub.1 is selected from OH, alkoxy, aryloxy, aralkyloxy and guanidinyl; R.sub.2 and R.sub.3 are independently selected from H, halogen, amino, hydroxyl, nitro, cyano and carboxyl; R.sub.4 is H, alkyl or acyl; R.sub.5 is selected from H, hydroxyl, halogen, nitro, alkyl, alkoxy, amino, cyclic amino, alkylamino, arylamino and aralkylamino wherein the alkyl, aryl and cyclic moieties are optionally substituted; R.sub.6 and R.sub.7 are independently selected from H, alkyl, alkoxy, halogen and amino; and R.sub.8 and R.sub.9 are independently selected from H, C.sub.1-4 alkyl, alkoxy, acyl, acyloxy, alkoxycarbonyl, hydroxyl, halogen, amino and carboxyl. The compounds have therapeutic or prophylactic use for treating bacterial infection in mammals.
    Type: Grant
    Filed: September 8, 1999
    Date of Patent: December 5, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Pei-Pei Kung, Phillip Dan Cook, Charles John Guinosso
  • Patent number: 6150129
    Abstract: Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The compounds and compositions of the invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents including employment as species for effecting combinatorial synthesis.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: November 21, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew M. Kawasaki, Pei Pei Kung
  • Patent number: 6121433
    Abstract: Novel compounds and libraries of compounds based on nitrogen atoms that are joined together with spanner groups include "letters" i.e., functional groups, that are attached to the nitrogen atoms, to the spanner groups or to both the nitrogen atoms and the spanner groups to render the compounds and libraries of such compounds with diverse properties.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: September 19, 2000
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Pei Pei Kung
  • Patent number: 6107482
    Abstract: Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridges that interconnect one or more ring systems thereby forming a large cyclic structure. Located in each bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the macrocyclic compounds. In accordance with certain embodiments of the invention, libraries of such macrocyclic compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: August 22, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Haoyun An, Charles J. Guinosso, Pei-Pei Kung, Allister S. Fraser
  • Patent number: 5998419
    Abstract: Compositions comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups are prepared. The compounds of the present invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: December 7, 1999
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew M. Kawasaki, Pei Pei Kung
  • Patent number: 5817489
    Abstract: Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: October 6, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Pei Pei Kung, Andrew M. Kawasaki
  • Patent number: 5798360
    Abstract: Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The compounds and compositions of the invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents including employment as species for effecting combinatorial synthesis.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: August 25, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew M. Kawasaki, Pei Pei Kung
  • Patent number: 5731438
    Abstract: Compositions comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups are prepared. The compounds of the present invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: March 24, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew M. Kawasaki, Pei Pei Kung