Abstract: Provided is an electrode mixture including: an electrode active material; an organic solvent; a binder; and an additive; wherein the binder contains a fluorine-containing copolymer containing a vinylidene fluoride unit and a fluorinated monomer unit, provided that the vinylidene fluoride unit is excluded from the fluorinated monomer unit; the additive is a polymer material containing the following repeating unit: —[CH2—CHR]— wherein R is a chain or cyclic amide group, a nitrile group, or a substituted alkyl group formed by substituting at least one of hydrogen atoms of an alkyl group having 1 to 4 carbon atoms with a chain or cyclic amide group or a nitrile group; a content of the binder is 0.1 to 1.6 parts by mass with respect to 100 parts by mass of the electrode active material; and a content of the additive is 0.001 to 0.2 parts by mass with respect to 100 parts by mass of the electrode active material.

Abstract: Disclosed herein, in certain embodiments, are methods of inducing cell cycle arrest, apoptosis, cell death, or a combination thereof, in a cell or population of cells. Also disclosed herein are methods of treating a disease or condition in an individual in need thereof comprising inducing cell cycle arrest, apoptosis, cell death, or a combination thereof in a population of cells in the individual. The cell or population of cells may comprise a nucleic acid sequence associated with a disease or condition, including an autoimmune disease, cancer, or an infectious disease. The methods described herein generally comprise contacting cells with a CRISPR-associated protein and a guide nucleic acid.

Abstract: Provided are a database processing method and apparatus, and a computer readable storage medium. The database processing method comprises: after a lock wait is generated, writing lock wait related information into a lock wait log.

Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.

Abstract: A universal adaptor for door handle, operable to be universally assembled in a polygonal assembling groove of one of multiple types of handles, so that the above-mentioned handle forms a panel-like lock handle and is locked to a panel lock, and includes a lock portion and a universal extension portion. The lock portion is formed with at least one lock hole corresponding to the panel lock. The universal extension portion is connected to the lock portion and extends along an extension direction to form a polygonal rod structure, and a catching-type fit relationship is formed between the polygonal rod structure and the polygonal assembling groove. The present disclosure can achieve the functions and effects of universally assembling in polygonal assembling grooves of handles with different appearances and thereby enabling the handles to be locked to panel locks.

Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.

Abstract: Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.

Abstract: The present disclosure provides a system for regulating expression of a target polynucleotide in a cell. The system may comprise a chimeric polypeptide comprising a gene modulating polypeptide fused in-frame with a heterologous nuclear localization domain. The heterologous nuclear localization domain may be operable to translocate the chimeric polypeptide to a cell nucleus upon activation by an active cellular signaling pathway. The cellular signaling pathway may be inducible in response to an extracellular signal. In response to the extracellular signal, the chimeric polypeptide may localize to the cell nucleus and the gene modulating polypeptide may regulate expression of a target polynucleotide in the cell nucleus.

Abstract: The present disclosure provides systems, methods, and compositions for conditionally regulating expression of a target gene. Aspects of the present disclosure utilize intracellular signal transduction pathways to regulate the expression of a gene (e.g., transgene, exogenous gene, endogenous gene).

Abstract: Methods and compositions for treatment of a beta thalessemia are provided.

Abstract: Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

Abstract: In one implementation, an input power management component receives an input power, and determines whether an input current and voltage satisfies predetermined thresholds. A boost component generates a boost output voltage using the input voltage if the input current satisfies a predetermined current threshold, and a step-down charging component converts the boost output voltage to a voltage for charging a battery and system power management.

Abstract: Methods and compositions for treatment of a beta thalessemia are provided.

Abstract: Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

Abstract: Methods of and apparatus for controlling power drawn by an appliance through a USB port. The method includes limiting any electrical current drawn by an appliance to one of seven levels according to whether the data lines receive a bias from a power line, the data lines are in electrical communication with each other, and the power source includes a host computing device, or according to logic and voltage levels of the data lines when any of the pull-down resistor and the current and voltage sources are connected or not connected to the D+ data line. The apparatus includes a controller programmed to selectively connect a pull-down resistor, a current source, and a voltage source to a D+ data line and to limit any electrical current drawn from a power source to one of the seven levels according to voltage levels on the D+ data line and a D? data line.

Abstract: In one implementation, an input power management component receives an input power, and determines whether an input current and voltage satisfies predetermined thresholds. A boost component generates a boost output voltage using the input voltage if the input current satisfies a predetermined current threshold, and a step-down charging component converts the boost output voltage to a voltage for charging a battery and system power management.

Abstract: Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

Abstract: Methods of and apparatus for controlling power drawn by an appliance through a USB port. The method includes limiting any electrical current drawn by an appliance to one of seven levels according to whether the data lines receive a bias from a power line, the data lines are in electrical communication with each other, and the power source includes a host computing device, or according to logic and voltage levels of the data lines when any of the pull-down resistor and the current and voltage sources are connected or not connected to the D+ data line. The apparatus includes a controller programmed to selectively connect a pull-down resistor, a current source, and a voltage source to a D+ data line and to limit any electrical current drawn from a power source to one of the seven levels according to voltage levels on the D+ data line and a D? data line.

Abstract: Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.

Abstract: Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.