Abstract: A drawer slide with a two-way opening and closing structure includes: a main rail, a pivot block pivotally provided on the main rail, a slide rail slidably mounted on the main rail, and a pull lever pivotally disposed on the slide rail. The main rail has a limiting portion disposed along a vertical direction. The pivot block has an offset post movably disposed at the limiting portion along the vertical direction, and a first dislocation block which can be locked with a second dislocation block of the pull lever in a staggered manner. The user can set two sets of identical drawer slides with the two-way opening and closing structure on two sides of the drawer, and the first and second dislocation blocks can be misaligned by the limiting portion, namely, two identical slide rails 40 can be applied to the two opposite sides of the drawer.