Abstract: Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use.

Abstract: A computer-implemented critical path method (CPM) scheduling system and method integrates carbon emissions associated with construction activities and permits a user to schedule a construction project including those activities. Information is stored regarding one or more milestones, phases, and activities associated with the project. The activity information includes interdependency and carbon emissions information associated with the activity. Based on the milestone information, phase information, and activity information, one or more of the following is calculated: a project schedule; identification, duration, date, and total carbon emission information for key activities; duration, date, and total carbon emission information for phases; and date and total carbon emission information for milestones.

Abstract: The present disclosure provides a method for detecting a population density of Cryptolestes ferrugineus based on a CO2 release rate, and belongs to the technical field of pest detection in stored grains. In the present disclosure, the method includes: constructing a prediction model of a population density of Cryptolestes ferrugineus based on a relationship between different stored grain temperatures, stored grain water contents, and CO2 release rates in the environment and the population density of the Cryptolestes ferrugineus; measuring the stored grain temperature and the CO2 release rate in the environment, substituting measured values into the prediction model of the population density of the Cryptolestes ferrugineus for calculation to obtain the population density of the Cryptolestes ferrugineus in a grain storage environment; and determining a pest-carrying grain grade. The method can eliminate an interference of dead pests and death-feigning pests, and can also detect borer pests.

Abstract: Recombinant polynucleotides including a nucleic acid sequence encoding an engineered SARS-CoV-2 spike protein (S12) or an immunogenic fragment thereof, in which the engineered spike protein or immunogenic fragment includes one or more mutations in the S2 segment of the S12 ectodomain. Vaccines, pharmaceutical compositions, and methods of use of the polynucleotides, vaccines, and pharmaceutical compositions in treating, alleviating, or managing SARS-CoV-2 infection and/or one or more symptoms thereof.

Abstract: Disclosed is a method of synthesizing a (1R,2R)-nitroalcohol compound of formula (I), as shown in the following reaction scheme, including: subjecting a compound of formula (II) and a compound of formula (III) to a condensation reaction in an organic solvent in the presence of a copper complex generated in situ from a chiral (1S,2R)-amino alcohol ligand and a cupric salt to produce the (1R,2R)-nitroalcohol compound of formula (I), where R1 and R2 are defined in the same manner as that in the specification. The method involves mild reaction conditions, excellent diastereoselectivity and high chemical yield, and thus it is suitable for industrial applications.

Abstract: Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use.

Abstract: Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use.

Abstract: Disclosed is a method of synthesizing a (1R,2R)-nitroalcohol compound of formula (I), as shown in the following reaction scheme, including: subjecting a compound of formula (II) and a compound of formula (III) to a condensation reaction in an organic solvent in the presence of a copper complex generated in situ from a chiral (1S,2R)-amino alcohol ligand and a cupric salt to produce the (1R,2R)-nitroalcohol compound of formula (I), where R1 and R2 are defined in the same manner as that in the specification. The method involves mild reaction conditions, excellent diastereoselectivity and high chemical yield, and thus it is suitable for industrial applications.

Abstract: Disclosed herein is a method of synthesizing a (1S,12bS) lactam ester compound, including: subjecting a dihydrocarboline diester compound of formula (II) to asymmetric hydrogenation and lactamization in an organic solvent in the presence of an iridium catalyst precursor, a chiral diphosphine ligand and a halogen-containing reagent under hydrogen atmosphere to produce the (1S,12bS) lactam ester compound of formula (I), as shown in the following reaction scheme, where R1, R2 and R3 are defined in the same manner with the specification.

Abstract: Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use.

Abstract: Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions including these engineered chloride channel receptors, nucleic acids, and expression vectors are disclosed. The use of these compositions and nanoparticles, such as for the treatment of pain, cystic fibrosis and asthma, is also disclosed.

Abstract: Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions including these engineered chloride channel receptors, nucleic acids, and expression vectors are disclosed. The use of these compositions and nanoparticles, such as for the treatment of pain, cystic fibrosis and asthma, is also disclosed.

Abstract: Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions including these engineered chloride channel receptors, nucleic acids, and expression vectors are disclosed. The use of these compositions and nanoparticles, such as for the treatment of pain, cystic fibrosis and asthma, is also disclosed.

Abstract: Among other things, one or more techniques and/or systems are provided for driving a body of a polishing head using an alignment gear. That is, an alignment gear, coupled to a housing of the polishing head, can transfer rotational force from the housing to the body responsive to the alignment gear being mated with a channel associated with the body. For example, the housing can supply pressure to the body, resulting in the body and the housing moving towards one another into a mated state. When the body and the housing are in the mated state, the alignment gear can mate with the channel (e.g., the alignment gear can fit within the channel). In this way, the alignment gear can drive the body by transferring rotational force to the body, resulting in the body rotating a semiconductor wafer against a polishing pad to polish the semiconductor wafer, for example.

Abstract: Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions including these engineered chloride channel receptors, nucleic acids, and expression vectors are disclosed. The use of these compositions and nanoparticles, such as for the treatment of pain, cystic fibrosis and asthma, is also disclosed.

Abstract: Among other things, one or more techniques and/or systems are provided for driving a body of a polishing head using an alignment gear. That is, an alignment gear, coupled to a housing of the polishing head, can transfer rotational force from the housing to the body responsive to the alignment gear being mated with a channel associated with the body. For example, the housing can supply pressure to the body, resulting in the body and the housing moving towards one another into a mated state. When the body and the housing are in the mated state, the alignment gear can mate with the channel (e.g., the alignment gear can fit within the channel). In this way, the alignment gear can drive the body by transferring rotational force to the body, resulting in the body rotating a semiconductor wafer against a polishing pad to polish the semiconductor wafer, for example.

Abstract: A method for adjusting frame brightness is provided. First, an image data in YUV format is received. Next, a dimming curve is determined according to an overall average pixel level value of the image data and a number distribution of pixel level values. Then, the image data is divided into a plurality of blocks, and a block average pixel level value of pixels in each of the blocks is calculated. Thereafter, the block average pixel level values are substituted into the dimming curve to obtain a plurality of block brightness values. Afterward, the image data is outputted and backlight sources corresponding to each of the blocks are driven to provide the block brightness values to each of the blocks for displaying a frame.

Abstract: A color adjusting method for a display is provided. The color adjusting method includes establishing a primary color adjusting mode in an on-screen-display (OSD) menu of the display, wherein the primary color adjusting mode at least has one of red, green and blue color adjusting mode items; providing a standard test video signal to the display so as to make that the display displays a standard test pattern; and when one of the red, green, blue color adjusting mode items under the primary color adjusting mode is turned on, attenuating (green and blue)/(red and blue)/(red and green) components in the standard test pattern, so as to make that the display only displays one of the red, green, blue components in the standard test pattern, and thus adjusting one of the red, green, blue colors by users.

Abstract: A method for increasing a frame contrast ratio is suitable for a liquid crystal display (LCD) having a direct-type light emitting diode (LED) backlight module. The method includes establishing a local dimming demo mode in an on-screen-display (OSD) menu of the LCD, so as to determine to turn on or turn off a local dimming control function. Besides, according to this method, when the local dimming demo mode is turned on, the local dimming control function is continuously and repeatedly turned on or turned off in the direct-type LED backlight module in a time-division manner based on image contents in the whole frame of the LCD, so as to increase the frame contrast ratio of the LCD.

Abstract: A measuring apparatus for measuring capacitance of a capacitor includes a microprocessor, a control circuit coupled to the capacitor, and an Analog-to-Digital (A/D) converting circuit. The control circuit receives a control signal from the microprocessor, and outputs an analog voltage signal of the capacitor, and the control circuit charges/discharges the capacitor according to the control signal. The A/D converting circuit receives the analog voltage signal from the control circuit, and outputs a digital voltage signal. The microprocessor receives the digital voltage signal from the A/D converting circuit, and calculates capacitance of the capacitor according to the digital voltage signal and charge/discharge time.