Abstract: The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

Abstract: A machine tool feed drive design system is provided, which may include a component database, a detection module, a load condition estimation module and a calculation module. The component database may store the specification data of a plurality of feed drive components. The detection module may detect a plurality of operation signals from a machine tool during a period of time when the machine tool had been executing a machining process to a workpiece. The load condition estimation module may calculate a plurality of actual load conditions according to the operation signals and a device specification parameter of a feed drive of the machine tool. The calculation module may select at least one component combination from the feed drive components according to the actual load conditions and the specification data of the feed drive components to serve as an optimized feed drive specification.

Abstract: The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

Abstract: A method and system for identifying and labeling fraudulent store return activities includes receiving, by a server, retailer events from an online transaction system of a retailer, the retailer events comprising records of transactions between customers and the retailer, including sale, exchange and return activities across multiple stores. The retailer events are processed to build a network that associates stores, transactions, payment instruments, and customer identification over related activity sequences of transactions.

Abstract: This invention relates to a kind of C- aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C- aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention relates to a kind of C- aryl glycoside derivatives, it's pharmaceutically acceptable salts or compositions thereof for preparing a SGLT inhibitor. The C- aryl glycoside derivatives of this invention provides a new direction for SGLT inhibitors.

Abstract: The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present invention further provides a method for preparing a mouse with fat-specific overexpression of Metrnl.

Abstract: The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

Abstract: A method, system, and/or computer program product automatically detects CSS conflicts. The method comprises: receiving at least one UI constraint and at least one first CSS rule defined by a developer of a widget as well as at least one second CSS rule customized by a user of the widget, the UI constraints being used to restrict the UI of the widget; running a page containing the widget; performing automatic validation on each UI constraint based on the result of running the page; and in response to deriving a UI constraint being violated from the validation, finding one or more of the second CSS rules that lead to violation of the UI constraint in a first set made up of the second CSS rules that override the first CSS rules.

Abstract: A mold which is made of a porous heat-resistant material comprises a first surface and a second surface opposite to the first surface. A plurality of light guide spots are formed on the first surface. The light guide spots are light guide spots. The first surface is a smooth polished surface, the mold enables direct manufacture of light guide plates for less heat expended.

Abstract: This disclosure relates to baseline restoration methods and apparatuses and medical detecting equipment thereof. The baseline restoration method comprises: determining whether there is a high-amplitude baseline in an input signal by previous k output signals (Y1, . . . , Yk) of a filter, where k is a natural number and k?1; setting the previous m output signals (Y1, . . . , Ym) of the filter as Y? when there is a high-amplitude baseline in the input signal, where Y? is a desired output signal of the filter; and using a current input signal X0, the previous n input signals (X1, . . . , Xn), and the previous m output signals (Y1, . . . , Ym) of said filter to obtain a current output signal Y0 of said filter.

Abstract: An apparatus and method of producing a pump including a housing and a cam received within the housing that is rotatable relative to the housing. The cam includes an axis of rotation. The pump further includes a retainer plate operable to abut the cam to restrict movement of the cam in a first direction along the axis of rotation. The pump further includes a biaser, such as a spring, operable to place a first constant force in the first direction on the retainer plate.

Abstract: There is provided a method of centralized processing of a benefit for an employee. The method includes receiving a notification of a deposit made to an account in a financial institution, and thereafter facilitating a payment from the account to a provider of the benefit. The method is performed independently of an employer, even after the employee is no longer employed by the employer, and even if the employee changes jobs and works for a different employer. There is also provided a system that performs the method, and a storage device that includes instructions that control a processor to perform the method. Centralized processing relieves systems of the employer(s) of such responsibility, thus reducing duplication of effort, and providing for more efficient utilization of processing resources.

Abstract: A process-orientated design method for machine tool structures comprises the steps of: (A) Defining design conditions including initial configurations, cutting requirements and boundary conditions for the machine tool; (B) Calculating cutting ability to generate information realizing a relationship between a maximum cutting depth and a spindle speed of the machine tool based on the initial configurations and the cutting requirements; (C) Performing an optimization to generate a frequency range for optimization based on the information relating the maximum cutting depth and the spindle speed; (D) Performing structural topology optimization to generate an optimized model based on the frequency range for optimization, the initial configurations and boundary conditions; and (E) Determining whether the optimized model fits the constraint condition; if positive, ends the design steps, and otherwise repeats steps (B)˜(D) until an optimized model fits the constraint condition appears.

Abstract: This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor.

Abstract: An article of manufacture making system for making an article of manufacture containing a plurality of dry solid additives, such as fibers, that utilizes a dry solid additive delivery system.

Abstract: The present invention provides a compound of Formula (I) and a salt thereof, wherein, m is an integer of 2 to 7, and R is independently at least one selected from the group consisting of hydrogen and C1-C20 alkyl. The compound promotes apoptosis in cancer cell and inhibits its growth. The present invention also provides a pharmaceutical composition which comprises the compound of Formula (I), a salt thereof and a pharmaceutically acceptable carrier. The present invention further provides a method for production of the pharmaceutical composition used for treating cancer.

Abstract: A hollow-type planet speed reducer includes a body. The body includes at least one driving gear driven by a power input source. The driving gear is connected to a transmission gear, and the transmission gear is connected to a first gear. Based on this, the output rotation speed can be reduced by the incorporation of the driving gear, the transmission gear and the first gear. Besides, a tubular member passes though the body and has an accommodating space to receive wires of the hollow-type planet speed reducer.

Abstract: This disclosure relates to baseline restoration methods and apparatuses and medical detecting equipment thereof. The baseline restoration method comprises: determining whether there is a high-amplitude baseline in an input signal by previous k output signals (Y1, . . . , Yk) of a filter, where k is a natural number and k?1; setting the previous m output signals (Y1, . . . , Ym) of the filter as Y? when there is a high-amplitude baseline in the input signal, where Y? is a desired output signal of the filter; and using a current input signal X0, the previous n input signals (X1, . . . , Xn), and the previous m output signals (Y1, . . . , Ym) of said filter to obtain a current output signal Y0 of said filter.

Abstract: Mutation signal processing methods, devices and medical detecting apparatuses are described. The method includes detecting whether or not a mutation signal exists in an input signal; if the mutation signal exists in the input signal, processing the input signal by a filter to obtain an output signal, and updating a prestored difference value according to a difference value obtained by subtracting the output signal from the input signal; and if the mutation signal does not exist in the input signal, using a difference value obtained by subtracting the prestored difference value from the input signal as the output signal.

Abstract: Methods and devices for switching filters and medical apparatuses using the same are described. The method includes: detecting whether or not a frequency range of an input signal is changed from a first frequency range into a second frequency range; if changed, switching from a first filter to a second filter, and taking a sample value of the input signal at a current moment as an input value of the second filter at the current moment and sample values of the input signal at n moments before the current moment as input values of the second filter at the n moments, respectively, and taking output values of the first filter at m moments before the current moment as output values of the second filter at the m moments, to obtain an output value of the second filter at the current moment.