Patents by Inventor Pei-Wen Yang

Pei-Wen Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250197947
    Abstract: The present disclosure provides a method and a gene detection panel for evaluating treatment response, recurrence and survival by detecting genetic variants and their changes before and after concurrent chemoradiotherapy in tumor tissues of patients with esophageal cancer. The present disclosure develops a set of esophageal cancer NGS analysis panel. Aiming at 402 mutation sites including 35 genes that frequently occur in esophageal squamous cell carcinoma tissue cells, 62 pairs of esophageal squamous cell carcinoma tissues before and after CCRT are analyzed for specific site variation, hoping to find new predictive markers. The present disclosure combines these potential markers into an esophageal cancer detection panel, which has extremely high value for improving the prognosis of esophageal cancer.
    Type: Application
    Filed: December 12, 2024
    Publication date: June 19, 2025
    Inventors: Hung-Tai Wu, Yen-Su Huang, Hang Chang, Yu-Jen Chen, Pei-Wen Yang
  • Patent number: 10746651
    Abstract: The present invention provides an optical method for predicting treatment response, survival and recurrence of esophageal cancer patients, comprising analyzing the spectral signatures of patient's tumor tissue spectra. By the features of the present invention, the prediction result achieves the sensitivity of 75% and specificity of 73.3% in concurrent chemoradiotherapy (CCRT) response; the survival prediction rate achieves the sensitivity of 100%; the recurrence prediction rate achieves the sensitivity of 85.7%.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: August 18, 2020
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Jang-Ming Lee, I-Jen Hsu, Max Ti-Kuang Hou, Pei-Wen Yang
  • Publication number: 20190017925
    Abstract: The present invention provides an optical method for predicting treatment response, survival and recurrence of esophageal cancer patients, comprising analyzing the spectral signatures of patient's tumor tissue spectra. By the features of the present invention, the prediction result achieves the sensitivity of 75% and specificity of 73.3% in concurrent chemoradiotherapy (CCRT) response; the survival prediction rate achieves the sensitivity of 100%; the recurrence prediction rate achieves the sensitivity of 85.7%.
    Type: Application
    Filed: September 13, 2017
    Publication date: January 17, 2019
    Inventors: JANG-MING LEE, I-JEN HSU, MAX TI-KUANG HOU, PEI-WEN YANG
  • Publication number: 20130017961
    Abstract: The present invention relates to novel genetic markers associated with response of a patient with esophageal cancer (ECa) to chemoradiation therapy, and particularly to methods and kits for predicting an ECa patient's response to chemoradiation therapy by genotyping of the markers.
    Type: Application
    Filed: August 13, 2012
    Publication date: January 17, 2013
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: Pei-Chun Chen, Yen-Ching Chen, Liang-Chuan Lai, Mong-Hsun Tsai, Shin-Kuang Chen, Pei-Wen Yang, Jang-Ming Lee, Eric Y. Chuang, Chuhsing K. Hsiao
  • Patent number: 8268562
    Abstract: The present invention relates to novel genetic markers associated with response of a patient with esophageal cancer (ECa) to chemoradiation therapy, and particularly to methods and kits for predicting an ECa patient's response to chemoradiation therapy by genotyping of the markers.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: September 18, 2012
    Assignee: National Taiwan University
    Inventors: Pei-Chun Chen, Yen-Ching Chen, Liang-Chuan Lai, Mong-Hsun Tsai, Shin-Kuang Chen, Pei-Wen Yang, Jang-Ming Lee, Eric Y. Chuang, Chuhsing K. Hsiao
  • Publication number: 20110091871
    Abstract: The present invention relates to novel genetic markers associated with response of a patient with esophageal cancer (ECa) to chemoradiation therapy, and particularly to methods and kits for predicting an ECa patient's response to chemoradiation therapy by genotyping of the markers.
    Type: Application
    Filed: October 20, 2009
    Publication date: April 21, 2011
    Applicant: National Taiwan University
    Inventors: Pei-Chun Chen, Yen-Ching Chen, Liang-Chuan Lai, Mong-Hsun Tsai, Shin-Kuang Chen, Pei-Wen Yang, Jang-Ming Lee, Eric Y. Chuang, Chuhsing K. Hsiao