Patents by Inventor Pei Yong Chow
Pei Yong Chow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170325481Abstract: A method of forming an encapsulated composition with enhanced solubility and stability. A bicontinuous or Winsor Type III microemulsion is formed using an emulsifier, a solvent and a co-emulsifier. An active composition is added to the microemulsion resulting in a micellar network of the active composition within the microemulsion. The active composition can be either water-soluble or oil-soluble or both.Type: ApplicationFiled: May 26, 2017Publication date: November 16, 2017Inventors: Pei-Yong CHOW, Hai Meng TAN, Harish METHIL
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Publication number: 20160015765Abstract: Natural plant parts and extracts of plants selected from the group consisting of Quercus infectoria, Rhus chinensis and Terminalia chebula containing compounds such as gallic acid, derivative of gallic acid, gallotannins and hydrolysable tannins have been found to control coccidiosis in poultry and, more specifically, coccidiosis caused by Eimeria spp. The plant parts and natural extracts result in a reduction of lesion score, oocysts per gram of fecal matter and mortality.Type: ApplicationFiled: July 17, 2015Publication date: January 21, 2016Inventors: Gokila Thangavel, Rajalekshmi Mukkalil, Haridasan Chirakkal, Hannah Kurian, Elke Schoeters, Hilde Wouters, Ilse Mast, Pei-Yong Chow, Bruno Coppens, Sripathy Ravichandran
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Publication number: 20150273004Abstract: Natural plant parts and extracts of plants selected from the group consisting of Quercus infectoria, Rhus chinensis and Terminalia chebula containing compounds such as gallic acid, derivative of gallic acid, gallotannins and hydrolysable tannins have been found to control coccidiosis in poultry and, more specifically, coccidiosis caused by Eimeria spp. The plant parts and natural extracts result in a reduction of lesion score, oocysts per gram of fecal matter and mortality.Type: ApplicationFiled: March 31, 2015Publication date: October 1, 2015Inventors: Gokila Thangavel, Rajalekshmi Mukkalil, Haridasan Chirakkal, Hannah Kurian, Elke Schoeters, Hilde Wouters, Ilse Mast, Pei-Yong Chow, Bruno Coppens, Sripathy Ravichandran
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Patent number: 8513353Abstract: A copolymer defines interconnected pores and comprises polymerized monomers. The monomers comprise a first monomer more hydrophilic than 2-hydroxyethyl methacrylate (HEMA), and a second monomer as hydrophilic as, or less hydrophilic than, HEMA. In a method of forming a polymer, a bicontinuous microemulsion comprising water, a surfactant, and a combination of monomers copolymerizable for forming a porous copolymer is provided. The combination of monomers comprises the first and second monomers. The monomers in the bicontinuous microemulsion are polymerized to form the porous copolymer. The first monomer may comprise N-vinylpyrrolidone (NVP) or methacrylic acid (MAA). The second monomer may comprise HEMA or methyl methacrylate (MMA).Type: GrantFiled: March 19, 2009Date of Patent: August 20, 2013Assignee: Agency for Science, Technology and ResearchInventors: Edwin Pei Yong Chow, Jackie Y. Ying
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Publication number: 20130045238Abstract: The present invention generally relates to transdermal delivery and, in particular, to transdermal delivery using nanoemulsions and other emulsions. In one aspect, the present invention is directed to emulsions comprising a first, continuous phase and a second, discontinuous phase. The first phase may be an aqueous liquid and the second phase may comprise a lipid, such as isopropyl myristate. In some cases, a surfactant, such as Pluronic® L61, is used to stabilize the emulsion. Surprisingly, it has been found that such emulsions are effective at delivering pharmaceutically active agents, such as ciprofloxacin, when the formulation has a very low water content, for example, less than 30 wt % or less than 10 wt %. This is surprising because high water contents—not low water contents—are typically correlated with greater transdermal drug delivery, and thus, a low water content would have been considered to be unfavorable for facilitating transdermal drug delivery.Type: ApplicationFiled: April 22, 2010Publication date: February 21, 2013Applicant: Agency for Science, Technology and ResearchInventors: Edwin Pei Yong Chow, Jackie Y. Ying, Shu Jun Gao
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Publication number: 20130004619Abstract: A method of forming an encapsulated composition with enhanced solubility and stability. A bicontinuous or Winsor Type III microemulsion is formed using an emulsifier, a solvent and a co-emulsifier. An active composition is added to the microemulsion resulting in a micellar network of the active composition within the microemulsion. The active composition can be either water-soluble or oil-soluble or both.Type: ApplicationFiled: June 27, 2012Publication date: January 3, 2013Applicant: KEMIN INDUSTRIES, INC.Inventors: Pei-Yong Chow, Lay-Beng Goh
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Publication number: 20120309761Abstract: A bicontinuous microemulsion of water, a monomer, and a surfactant copolymerizable with the monomer is polymerized to form a polymeric material, the polymeric material comprising a polymer matrix defining interconnected pores. The polymeric material may additional comprise at least one photochromic agent. The photochromic agent may be dispersed in one or both of the polymer matrix or the interconnected pores. The polymeric material may be used to form photochromic articles including ophthalmic articles such as contact lenses.Type: ApplicationFiled: October 27, 2010Publication date: December 6, 2012Applicant: Agency for Science, Technology and ResearchInventors: Edwin Pei Yong Chow, Jackie Y. Ying, Yuri Shona Pek
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Publication number: 20120202741Abstract: The present invention generally relates to delivery of BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist and methods of use thereof. In some embodiments, methods and devices are provided for delivery of BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist to a patient. In some cases, the BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be released in controlled fashion from a device in fluid communication with a patient. In some embodiments, the BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be expressed by cells within a device. In other embodiments, methods are provided for improving the function of devices containing renal proximal tubule cells.Type: ApplicationFiled: October 6, 2010Publication date: August 9, 2012Applicant: Agency for Science, Technology and ResearchInventors: Daniele Zink, Jackie Y. Ying, Edwin Pei Yong Chow, Farah Tasnim
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Publication number: 20120184940Abstract: The present invention generally relates to improved bioartificial kidneys (BAKs), and in certain embodiments to improved bioartificial kidneys that are portable and/or wearable by a user. In some embodiments, the BAKs may comprise an ultrafiltration unit and a reabsorption unit. The reabsorption unit may contain a reabsorption membrane having a layer of renal proximal tubule cells disposed thereon, where the renal proximal tubule cells selectively allow solutes to pass through the reabsorption membrane. In some embodiments, at least the reabsorption unit may be configured as a substantially flat-plate filtration device, which can impart advantageous properties such as improved maintenance of the renal proximal tubule cell layer, more facile monitoring of the renal proximal tubule cell layer as well as enhanced profile for wearability.Type: ApplicationFiled: October 4, 2010Publication date: July 19, 2012Applicant: Agency for Science, Technology and ResearchInventors: Jackie Y. Ying, Edwin Pei Yong Chow, Jeremy C.M. Teo, Karl Schumacher, Jeremy Ming Hock Loh, Rosa Yue Qi, Qunya Ong
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Publication number: 20120035288Abstract: A copolymer defines interconnected pores and comprises polymerized monomers. The monomers comprise a first monomer more hydrophilic than 2-hydroxyethyl methacrylate (HEMA), and a second monomer as hydrophilic as, or less hydrophilic than, HEMA. In a method of forming a polymer, a bicontinuous microemulsion comprising water, a surfactant, and a combination of monomers copolymerizable for forming a porous copolymer is provided. The combination of monomers comprises the first and second monomers. The monomers in the bicontinuous microemulsion are polymerized to form the porous copolymer. The first monomer may comprise N-vinylpyrrolidone (NVP) or methacrylic acid (MAA). The second monomer may comprise HEMA or methyl methacrylate (MMA).Type: ApplicationFiled: March 19, 2009Publication date: February 9, 2012Applicant: Agency for Science, Technology and ResearchInventors: Edwin Pei Yong Chow, Jackie Y. Ying
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Publication number: 20110129924Abstract: Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a first crosslinkable component and a second component that can be precipitated in a precipitation medium. The structure precursor material may be shaped into a three-dimensional shape by a suitable technique such as three-dimensional printing. Upon shaping of the structure precursor material, at least a portion of the first component may be crosslinked. The structure may then be contacted with a precipitation medium to remove the precursor solvent from the structure, which can cause the second polymer component to precipitate and form a porous structure containing a network of uniform pores.Type: ApplicationFiled: September 12, 2006Publication date: June 2, 2011Applicant: Agency for Science, Technology and ResearchInventors: Jackie Y. Ying, Edwin Pei Yong Chow, Jeremy Ming Hock Loh, Karl Schumacher
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Publication number: 20100048755Abstract: A porous material is provided which comprises a transparent polymer matrix defining interconnected pores and a wetting agent. At least a portion of the wetting agent is cross-linked with the polymer matrix. A process for forming a porous polymeric material is also provided. A bicontinuous microemulsion comprising water, a wetting agent, a monomer, and a surfactant copolymerizable with the monomer is polymerized, to form a polymer defining interconnected pores. The wetting agent comprises a cross-linkable wetting agent such that after polymerization, at least a portion of the cross-linkable wetting agent is cross-linked with the polymer. The wetting agent may comprise acrylated hyaluronic acid (AHA) such as methacrylated hyaluronic acid (MeHA). The wetting agent may also comprise a hyaluronic acid (HA). The wetting agent may include an unbonded portion that this releasable from the material. A contact lens may be made from the porous material.Type: ApplicationFiled: November 17, 2007Publication date: February 25, 2010Inventors: Edwin Pei Yong Chow, Jackie Y. Ying
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Patent number: 7074867Abstract: A compound having the general formula (I): ?O3S—R1—V1—R2—V2 wherein R1 is a hydrocarbon radical comprising C1 to C10 main chain carbon atoms, wherein hydrogen atoms bonded to the main chain carbon atoms are optionally substituted; R2 is a hydrocarbon radical comprising 6 to 20 main chain carbon atoms, wherein hydrogen atoms bonded to the main chain carbon atoms are optionally substituted; V1 is a saturated or unsaturated, monocyclic or bicyclic ring system comprising 5 to 9 ring atoms, wherein at least 2 ring atoms are nitrogen atoms forming the same cyclic moiety; and V2 is a moiety comprising a carboxyl group and an unsaturated carbon-carbon bond.Type: GrantFiled: November 21, 2003Date of Patent: July 11, 2006Assignee: Agency for Science, Technology and ResearchInventors: Leong Ming Gan, Pei Yong Chow
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Publication number: 20040171781Abstract: A compound having the general formula (I):Type: ApplicationFiled: November 21, 2003Publication date: September 2, 2004Inventors: Leong Ming Gan, Pei Yong Chow
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Publication number: 20030045664Abstract: A method of producing a polymer, the method comprising copolymerizing a mixture comprising about 15% to 50% by weight of water; about 10% to 50% by weight of at least one copolymerizable surfactant; and about 5% to 40% by weight of at least one copolymerizable monomer; whereby the resultant polymer has aqueous domains having sizes smaller than 100 nm. Also disclosed is a polymer comprising domains containing at least one polar solvent, the domains having sizes smaller than 100 nm and the density of the domains being at least about 3*103/&mgr;m3.Type: ApplicationFiled: June 21, 2002Publication date: March 6, 2003Inventors: Leong Ming Gan, Pei Yong Chow