Patents by Inventor Pei-Yun S. Hsueh
Pei-Yun S. Hsueh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11572477Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: GrantFiled: November 8, 2019Date of Patent: February 7, 2023Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Institute of Bioengineering and NanotechnologyInventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 11560484Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: GrantFiled: November 8, 2019Date of Patent: January 24, 2023Assignees: International Business Machines Corporation, Institute of Bioengineering and NanotechnologyInventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 11195133Abstract: Systems and methods for individual risk factor identification include identifying common risk factors for one or more risk targets from population data. Individuals are stratified into clusters based upon the common risk factors. A discriminability of each of the common risk factors is determined, using a processor, for a target cluster using individual data of the target cluster to provide re-ranked common risk factors as individual risk factors for the target cluster, such that the discriminability is a measure of how a risk factor discriminates its cluster from other clusters.Type: GrantFiled: May 9, 2018Date of Patent: December 7, 2021Assignee: International Business Machines CorporationInventors: David H. Gotz, Pei-Yun S. Hsueh, Jianying Hu, Jimeng Sun
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Publication number: 20200071543Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20200071542Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 10563069Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: GrantFiled: March 30, 2017Date of Patent: February 18, 2020Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Institute of Bioengineering and NanotechnologyInventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 10441189Abstract: A method, apparatus and system for measuring electrical activity generated within a brain is disclosed. A headpiece having a first transistor is placed in contact with a head that contains the brain to bring the first transistor into electrical contact with the head. An electronic signal is generated at the first transistor in response to the electrical activity generated within the brain. The electronic signal is processed at the headpiece in order to measure the electrical activity.Type: GrantFiled: December 15, 2015Date of Patent: October 15, 2019Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Amos Cahan, Hariklia Deligianni, Pei-Yun S. Hsueh
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Patent number: 10282875Abstract: One or more biological signals are obtained. The one or more biological signals are converted to one or more graph structures. Correlation between two or more of the biological signals are determined using the one or more graph structures. One or more changes in the one or more graph structures within a time window are recorded. A signal graph model is generated based on the recorded changes.Type: GrantFiled: December 11, 2015Date of Patent: May 7, 2019Assignee: International Business Machines CorporationInventors: Chia-Yu Chen, Pei-Yun S. Hsueh, Jui-Hsin Lai, Yinglong Xia
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Patent number: 10130255Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.Type: GrantFiled: December 15, 2016Date of Patent: November 20, 2018Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Hung-Yang Chang, Pei-Yun S Hsueh, Lih-Guong Jang, Joe Lu, Sreeram Ramakrishnan, Yi-Chang Wang, Nien-Chu Wu, Xinxin Zhu
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Publication number: 20180282556Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: ApplicationFiled: March 30, 2017Publication date: October 4, 2018Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20180260925Abstract: Systems and methods for individual risk factor identification include identifying common risk factors for one or more risk targets from population data. Individuals are stratified into clusters based upon the common risk factors. A discriminability of each of the common risk factors is determined, using a processor, for a target cluster using individual data of the target cluster to provide re-ranked common risk factors as individual risk factors for the target cluster, such that the discriminability is a measure of how a risk factor discriminates its cluster from other clusters.Type: ApplicationFiled: May 9, 2018Publication date: September 13, 2018Inventors: DAVID H. GOTZ, PEI-YUN S. HSUEH, JIANYING HU, JIMENG SUN
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Patent number: 9996889Abstract: Systems and methods for individual risk factor identification include identifying common risk factors for one or more risk targets from population data. Individuals are stratified into clusters based upon the common risk factors. A discriminability of each of the common risk factors is determined, using a processor, for a target cluster using individual data of the target cluster to provide re-ranked common risk factors as individual risk factors for the target cluster, such that the discriminability is a measure of how a risk factor discriminates its cluster from other clusters.Type: GrantFiled: October 1, 2012Date of Patent: June 12, 2018Assignee: International Business Machines CorporationInventors: David H. Gotz, Pei-Yun S. Hsueh, Jianying Hu, Jimeng Sun
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Patent number: 9883836Abstract: A system and method for monitoring a health status of a subject. The system comprises: a medical device implantable in the subject and having a passage or compartment through which blood flows through; a sensor device embedded at or near a surface of said passage within said medical device for generating signals suitable for measuring a Doppler shift effect occurring within said passage; and a control device coupled to said sensor device for measuring a liquid blood flow rate within said passage based on sensor generated signals outputs. The embedded sensor device comprises a first piezo-electric element configured to generate an acoustic excitation signal and a second piezo-electric element configured to receive said acoustic excitation signal. The second piezo-electric element emits a signal responsive to said acoustic excitation signal. Control device in real time compares a generated output signal with the input excitation signal to determine a Doppler frequency shift measurement.Type: GrantFiled: February 8, 2016Date of Patent: February 6, 2018Assignee: International Business Machines CorporationInventors: Amos Cahan, Hariklia Deligianni, Pei-Yun S. Hsueh, Theodore G. van Kessel
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Publication number: 20170224279Abstract: A system and method for monitoring a health status of a subject. The system comprises: a medical device implantable in the subject and having a passage or compartment through which blood flows through; a sensor device embedded at or near a surface of said passage within said medical device for generating signals suitable for measuring a Doppler shift effect occurring within said passage; and a control device coupled to said sensor device for measuring a liquid blood flow rate within said passage based on sensor generated signals outputs. The embedded sensor device comprises a first piezo-electric element configured to generate an acoustic excitation signal and a second piezo-electric element configured to receive said acoustic excitation signal. The second piezo-electric element emits a signal responsive to said acoustic excitation signal. Control device in real time compares a generated output signal with the input excitation signal to determine a Doppler frequency shift measurement.Type: ApplicationFiled: February 8, 2016Publication date: August 10, 2017Inventors: Amos Cahan, Hariklia Deligianni, Pei-Yun S. Hsueh, Theodore G. van Kessel
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Publication number: 20170164861Abstract: A method, apparatus and system for measuring electrical activity generated within a brain is disclosed. A headpiece having a first transistor is placed in contact with a head that contains the brain to bring the first transistor into electrical contact with the head. An electronic signal is generated at the first transistor in response to the electrical activity generated within the brain. The electronic signal is processed at the headpiece in order to measure the electrical activity.Type: ApplicationFiled: December 15, 2015Publication date: June 15, 2017Inventors: Amos Cahan, Hariklia Deligianni, Pei-Yun S. Hsueh
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Publication number: 20170169591Abstract: One or more biological signals are obtained. The one or more biological signals are converted to one or more graph structures. Correlation between two or more of the biological signals are determined using the one or more graph structures. One or more changes in the one or more graph structures within a time window are recorded. A signal graph model is generated based on the recorded changes.Type: ApplicationFiled: December 11, 2015Publication date: June 15, 2017Inventors: Chia-Yu Chen, Pei-Yun S. Hsueh, Jui-Hsin Lai, Yinglong Xia
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Publication number: 20170095151Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.Type: ApplicationFiled: December 15, 2016Publication date: April 6, 2017Inventors: Hung-Yang Chang, Pei-Yun S. Hsueh, Lih-Guong Jang, Joe Lu, Sreeram Ramakrishnan, Yi-Chang Wang, Nien-Chu Wu, Xinxin Zhu
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Patent number: 9552517Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.Type: GrantFiled: December 6, 2013Date of Patent: January 24, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Hung-Yang Chang, Pei-yun S Hsueh, Lih-Guong Jang, Joe Lu, Sreeram Ramakrishnan, Yi-Chang Wang, Nien-Chu Wu, Xinxin Zhu
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Publication number: 20150161783Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.Type: ApplicationFiled: December 6, 2013Publication date: June 11, 2015Applicant: International Business Machines CorporationInventors: Hung-Yang Chang, Pei-yun S Hsueh, Lih-Guong Jang, Joe Lu, Sreeram Ramakrishnan, Yi-Chang Wang, Nien-Chu Wu, Xinxin Zhu
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Publication number: 20140095186Abstract: Systems and methods for individual risk factor identification include identifying common risk factors for one or more risk targets from population data. Individuals are stratified into clusters based upon the common risk factors. A discriminability of each of the common risk factors is determined, using a processor, for a target cluster using individual data of the target cluster to provide re-ranked common risk factors as individual risk factors for the target cluster, such that the discriminability is a measure of how a risk factor discriminates its cluster from other clusters.Type: ApplicationFiled: October 24, 2012Publication date: April 3, 2014Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: DAVID H. GOTZ, PEI-YUN S. HSUEH, JIANYING HU, JIMENG SUN