Patents by Inventor Pei-Yun S. Hsueh

Pei-Yun S. Hsueh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11572477
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: February 7, 2023
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Institute of Bioengineering and Nanotechnology
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • Patent number: 11560484
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: January 24, 2023
    Assignees: International Business Machines Corporation, Institute of Bioengineering and Nanotechnology
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • Patent number: 11195133
    Abstract: Systems and methods for individual risk factor identification include identifying common risk factors for one or more risk targets from population data. Individuals are stratified into clusters based upon the common risk factors. A discriminability of each of the common risk factors is determined, using a processor, for a target cluster using individual data of the target cluster to provide re-ranked common risk factors as individual risk factors for the target cluster, such that the discriminability is a measure of how a risk factor discriminates its cluster from other clusters.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: December 7, 2021
    Assignee: International Business Machines Corporation
    Inventors: David H. Gotz, Pei-Yun S. Hsueh, Jianying Hu, Jimeng Sun
  • Publication number: 20200071543
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • Publication number: 20200071542
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • Patent number: 10563069
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: February 18, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Institute of Bioengineering and Nanotechnology
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • Patent number: 10441189
    Abstract: A method, apparatus and system for measuring electrical activity generated within a brain is disclosed. A headpiece having a first transistor is placed in contact with a head that contains the brain to bring the first transistor into electrical contact with the head. An electronic signal is generated at the first transistor in response to the electrical activity generated within the brain. The electronic signal is processed at the headpiece in order to measure the electrical activity.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: October 15, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Amos Cahan, Hariklia Deligianni, Pei-Yun S. Hsueh
  • Patent number: 10282875
    Abstract: One or more biological signals are obtained. The one or more biological signals are converted to one or more graph structures. Correlation between two or more of the biological signals are determined using the one or more graph structures. One or more changes in the one or more graph structures within a time window are recorded. A signal graph model is generated based on the recorded changes.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: May 7, 2019
    Assignee: International Business Machines Corporation
    Inventors: Chia-Yu Chen, Pei-Yun S. Hsueh, Jui-Hsin Lai, Yinglong Xia
  • Patent number: 10130255
    Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: November 20, 2018
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Hung-Yang Chang, Pei-Yun S Hsueh, Lih-Guong Jang, Joe Lu, Sreeram Ramakrishnan, Yi-Chang Wang, Nien-Chu Wu, Xinxin Zhu
  • Publication number: 20180282556
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Application
    Filed: March 30, 2017
    Publication date: October 4, 2018
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • Publication number: 20180260925
    Abstract: Systems and methods for individual risk factor identification include identifying common risk factors for one or more risk targets from population data. Individuals are stratified into clusters based upon the common risk factors. A discriminability of each of the common risk factors is determined, using a processor, for a target cluster using individual data of the target cluster to provide re-ranked common risk factors as individual risk factors for the target cluster, such that the discriminability is a measure of how a risk factor discriminates its cluster from other clusters.
    Type: Application
    Filed: May 9, 2018
    Publication date: September 13, 2018
    Inventors: DAVID H. GOTZ, PEI-YUN S. HSUEH, JIANYING HU, JIMENG SUN
  • Patent number: 9996889
    Abstract: Systems and methods for individual risk factor identification include identifying common risk factors for one or more risk targets from population data. Individuals are stratified into clusters based upon the common risk factors. A discriminability of each of the common risk factors is determined, using a processor, for a target cluster using individual data of the target cluster to provide re-ranked common risk factors as individual risk factors for the target cluster, such that the discriminability is a measure of how a risk factor discriminates its cluster from other clusters.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: June 12, 2018
    Assignee: International Business Machines Corporation
    Inventors: David H. Gotz, Pei-Yun S. Hsueh, Jianying Hu, Jimeng Sun
  • Patent number: 9883836
    Abstract: A system and method for monitoring a health status of a subject. The system comprises: a medical device implantable in the subject and having a passage or compartment through which blood flows through; a sensor device embedded at or near a surface of said passage within said medical device for generating signals suitable for measuring a Doppler shift effect occurring within said passage; and a control device coupled to said sensor device for measuring a liquid blood flow rate within said passage based on sensor generated signals outputs. The embedded sensor device comprises a first piezo-electric element configured to generate an acoustic excitation signal and a second piezo-electric element configured to receive said acoustic excitation signal. The second piezo-electric element emits a signal responsive to said acoustic excitation signal. Control device in real time compares a generated output signal with the input excitation signal to determine a Doppler frequency shift measurement.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: February 6, 2018
    Assignee: International Business Machines Corporation
    Inventors: Amos Cahan, Hariklia Deligianni, Pei-Yun S. Hsueh, Theodore G. van Kessel
  • Publication number: 20170224279
    Abstract: A system and method for monitoring a health status of a subject. The system comprises: a medical device implantable in the subject and having a passage or compartment through which blood flows through; a sensor device embedded at or near a surface of said passage within said medical device for generating signals suitable for measuring a Doppler shift effect occurring within said passage; and a control device coupled to said sensor device for measuring a liquid blood flow rate within said passage based on sensor generated signals outputs. The embedded sensor device comprises a first piezo-electric element configured to generate an acoustic excitation signal and a second piezo-electric element configured to receive said acoustic excitation signal. The second piezo-electric element emits a signal responsive to said acoustic excitation signal. Control device in real time compares a generated output signal with the input excitation signal to determine a Doppler frequency shift measurement.
    Type: Application
    Filed: February 8, 2016
    Publication date: August 10, 2017
    Inventors: Amos Cahan, Hariklia Deligianni, Pei-Yun S. Hsueh, Theodore G. van Kessel
  • Publication number: 20170164861
    Abstract: A method, apparatus and system for measuring electrical activity generated within a brain is disclosed. A headpiece having a first transistor is placed in contact with a head that contains the brain to bring the first transistor into electrical contact with the head. An electronic signal is generated at the first transistor in response to the electrical activity generated within the brain. The electronic signal is processed at the headpiece in order to measure the electrical activity.
    Type: Application
    Filed: December 15, 2015
    Publication date: June 15, 2017
    Inventors: Amos Cahan, Hariklia Deligianni, Pei-Yun S. Hsueh
  • Publication number: 20170169591
    Abstract: One or more biological signals are obtained. The one or more biological signals are converted to one or more graph structures. Correlation between two or more of the biological signals are determined using the one or more graph structures. One or more changes in the one or more graph structures within a time window are recorded. A signal graph model is generated based on the recorded changes.
    Type: Application
    Filed: December 11, 2015
    Publication date: June 15, 2017
    Inventors: Chia-Yu Chen, Pei-Yun S. Hsueh, Jui-Hsin Lai, Yinglong Xia
  • Publication number: 20170095151
    Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.
    Type: Application
    Filed: December 15, 2016
    Publication date: April 6, 2017
    Inventors: Hung-Yang Chang, Pei-Yun S. Hsueh, Lih-Guong Jang, Joe Lu, Sreeram Ramakrishnan, Yi-Chang Wang, Nien-Chu Wu, Xinxin Zhu
  • Patent number: 9552517
    Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: January 24, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Hung-Yang Chang, Pei-yun S Hsueh, Lih-Guong Jang, Joe Lu, Sreeram Ramakrishnan, Yi-Chang Wang, Nien-Chu Wu, Xinxin Zhu
  • Publication number: 20150161783
    Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.
    Type: Application
    Filed: December 6, 2013
    Publication date: June 11, 2015
    Applicant: International Business Machines Corporation
    Inventors: Hung-Yang Chang, Pei-yun S Hsueh, Lih-Guong Jang, Joe Lu, Sreeram Ramakrishnan, Yi-Chang Wang, Nien-Chu Wu, Xinxin Zhu
  • Publication number: 20140095186
    Abstract: Systems and methods for individual risk factor identification include identifying common risk factors for one or more risk targets from population data. Individuals are stratified into clusters based upon the common risk factors. A discriminability of each of the common risk factors is determined, using a processor, for a target cluster using individual data of the target cluster to provide re-ranked common risk factors as individual risk factors for the target cluster, such that the discriminability is a measure of how a risk factor discriminates its cluster from other clusters.
    Type: Application
    Filed: October 24, 2012
    Publication date: April 3, 2014
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: DAVID H. GOTZ, PEI-YUN S. HSUEH, JIANYING HU, JIMENG SUN