Patents by Inventor Peili Chen
Peili Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11885681Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 28, 2022Date of Patent: January 30, 2024Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 11717167Abstract: The inventors have developed tools for quantifying the mitochondrial redox state of in vivo, in situ tissue using resonance Raman spectroscopy. The tissue is illuminated with an excitation beam that causes the tissue to scatter Raman-shifted light, which is collected and analyzed to produce coefficients representing the relative concentrations of different chromophores in the tissue. These relative concentrations indicate the redox state of whole mitochondria, hemoglobin oxygen saturation, myoglobin oxygen saturation, and/or redox state of individual cytochrome complexes in mitochondria of the in vivo, in situ tissue. Quantifiable information about these states and/or saturations can be used to assess tissue health, including organ (dys)function before, during, and after surgery. For example, this information can be used to predict impending cardiac failure, to guide surgical interventions, to monitor organ health after transplantation, or to guide post-operative care.Type: GrantFiled: March 18, 2020Date of Patent: August 8, 2023Assignees: Pendar Technologies, LLC, Children's Medical Center CorporationInventors: John P. Romfh, Daryoosh Vakhshoori, John N. Kheir, Peili Chen, Brian Polizzotti, Joshua Salvin, Alison Perry
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Publication number: 20230109459Abstract: The present technology includes a system and method for monitoring a donor organ tissue using Raman spectroscopy. The technology enables real-time quantification of the mitochondrial redox state in the tissue sample taken from an organ intended for transplant using a compact device. The system is based on resonance Raman spectroscopy which can quantify a mitochondrial redox state in tissues using a Resonance Raman Reduced Mitochondrial Ratio. The mitochondrial redox state of the tissue sample acts as a marker of tissue function and may distinguish healthy versus damaged tissue. Moreover, these measures may correlate with transplantation outcomes.Type: ApplicationFiled: December 9, 2022Publication date: April 6, 2023Applicants: Pendar Technologies, LLC, The General Hospital CorporationInventors: John P. ROMFH, Daryoosh VAKHSHOORI, Peili CHEN, Shannon Tessier, Reinier De Vries, Stephanie Cronin
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Publication number: 20220333985Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 28, 2022Publication date: October 20, 2022Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Patent number: 11300448Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: December 22, 2020Date of Patent: April 12, 2022Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20210223100Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: December 22, 2020Publication date: July 22, 2021Inventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Patent number: 10921187Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: February 16, 2021Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20200281474Abstract: The inventors have developed tools for quantifying the mitochondrial redox state of in vivo, in situ tissue using resonance Raman spectroscopy. The tissue is illuminated with an excitation beam that causes the tissue to scatter Raman-shifted light, which is collected and analyzed to produce coefficients representing the relative concentrations of different chromophores in the tissue. These relative concentrations indicate the redox state of whole mitochondria, hemoglobin oxygen saturation, myoglobin oxygen saturation, and/or redox state of individual cytochrome complexes in mitochondria of the in vivo, in situ tissue. Quantifiable information about these states and/or saturations can be used to assess tissue health, including organ (dys)function before, during, and after surgery. For example, this information can be used to predict impending cardiac failure, to guide surgical interventions, to monitor organ health after transplantation, or to guide post-operative care.Type: ApplicationFiled: March 18, 2020Publication date: September 10, 2020Inventors: John P. ROMFH, Daryoosh VAKHSHOORI, John N. KHEIR, Peili CHEN, Brian POLIZZOTTI, Joshua SALVIN, Alison PERRY
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Patent number: 10527495Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: January 7, 2020Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20190368927Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Publication number: 20190368938Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Publication number: 20190368937Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20190368939Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10488260Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: November 26, 2019Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10488252Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: November 26, 2019Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 8248588Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.Type: GrantFiled: April 15, 2011Date of Patent: August 21, 2012Assignee: Thermo Scientific Portable Analytical Instruments Inc.Inventors: Masud Azimi, Arran Bibby, Christopher D. Brown, Peili Chen, Kevin J. Knopp, Daryoosh Vakhshoori, Peidong Wang
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Publication number: 20120092658Abstract: We disclose an apparatus comprising: a hand-portable optical analysis unit including an optical interface; and a device configured to receive and releasably engage the hand-portable optical analysis unit. The device comprises: a housing; a sample unit in the housing; and a resilient member configured to bias the sample unit and the hand-portable analysis unit towards each other when the hand-portable optical analysis unit is received in the device to compress a sample disposed between the sample unit and the optical interface of the optical analysis unit. Methods of analyzing samples are also disclosed.Type: ApplicationFiled: December 19, 2011Publication date: April 19, 2012Inventors: Masud AZIMI, Arran BIBBY, Christopher D. BROWN, Peili CHEN, Kevin J. KNOPP, Daryoosh VAKHSHOORI, Peidong WANG, Stephen MCLAUGHLIN
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Publication number: 20110309247Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.Type: ApplicationFiled: April 15, 2011Publication date: December 22, 2011Inventors: Masud Azimi, Arran Bibby, Christopher D. Brown, Peili Chen, Kevin J. Knopp, Daryoosh Vakhshoori, Peidong Wang
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Patent number: 8081305Abstract: We disclose an apparatus comprising: a hand-portable optical analysis unit including an optical interface; and a device configured to receive and releasably engage the hand-portable optical analysis unit. The device comprises: a housing; a sample unit in the housing; and a resilient member configured to bias the sample unit and the hand-portable analysis unit towards each other when the hand-portable optical analysis unit is received in the device to compress a sample disposed between the sample unit and the optical interface of the optical analysis unit. Methods of analyzing samples are also disclosed.Type: GrantFiled: March 30, 2009Date of Patent: December 20, 2011Assignee: Ahura Scientific Inc.Inventors: Masud Azimi, Arran Bibby, Christopher D. Brown, Peili Chen, Kevin J. Knopp, Daryoosh Vakhshoori, Peidong Wang, Stephen McLaughlin
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Patent number: 7928391Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.Type: GrantFiled: January 21, 2010Date of Patent: April 19, 2011Assignee: Ahura Scientific Inc.Inventors: Masud Azimi, Arran Bibby, Christopher D. Brown, Peili Chen, Kevin J. Knopp, Daryoosh Vakhshoori, Peidong Wang